Large socioeconomic gap in period life expectancy and life years spent with complications of diabetes in the Scottish population with type 1 diabetes, 2013-2018.

Autor: Andreas Höhn, Stuart J McGurnaghan, Thomas M Caparrotta, Anita Jeyam, Joseph E O'Reilly, Luke A K Blackbourn, Sara Hatam, Christian Dudel, Rosie J Seaman, Joseph Mellor, Naveed Sattar, Rory J McCrimmon, Brian Kennon, John R Petrie, Sarah Wild, Paul M McKeigue, Helen M Colhoun, SDRN-Epi Group

Publikováno v: PLoS ONE, Vol 17, Iss 8, p e0271110 (2022)

BackgroundWe report the first study to estimate the socioeconomic gap in period life expectancy (LE) and life years spent with and without complications in a national cohort of individuals with type 1 diabetes.MethodsThis retrospective cohort study u

Externí odkaz: https://doaj.org/article/f394b76607e74310b07f43990f9e185c

Use of personalised risk-based screening schedules to optimise workload and sojourn time in screening programmes for diabetic retinopathy: A retrospective cohort study.

Autor: Andreas Ochs, Stuart McGurnaghan, Mike W Black, Graham P Leese, Sam Philip, Naveed Sattar, Caroline Styles, Sarah H Wild, Paul M McKeigue, Helen M Colhoun, Scottish Diabetes Research Network Epidemiology Group and the Diabetic Retinopathy Screening Collaborative

Publikováno v: PLoS Medicine, Vol 16, Iss 10, p e1002945 (2019)

BACKGROUND:National guidelines in most countries set screening intervals for diabetic retinopathy (DR) that are insufficiently informed by contemporary incidence rates. This has unspecified implications for interval disease risks (IDs) of referable D

Externí odkaz: https://doaj.org/article/50276b4bab2d4077846c04a2ed51a1c0

Genome-wide aggregated trans-effects on risk of type 1 diabetes: A test of the 'omnigenic' sparse effector hypothesis of complex trait genetics

Autor: Andrii Iakovliev, Stuart J. McGurnaghan, Caroline Hayward, Marco Colombo, Debby Lipschutz, Athina Spiliopoulou, Helen M. Colhoun, Paul M. McKeigue

Publikováno v: Iakovliev, A, McGurnaghan, S J, Hayward, C, Colombo, M, Lipschutz, D, Spiliopoulou, A, Colhoun, H M & McKeigue, P M 2023, ' Genome-wide aggregated trans-effects on risk of type 1 diabetes : A test of the "omnigenic" sparse effector hypothesis of complex trait genetics ', American Journal of Human Genetics, vol. 110, no. 6, pp. 913-926 . https://doi.org/10.1016/j.ajhg.2023.04.003

The "omnigenic" hypothesis postulates that the polygenic effects of common SNPs on a typical complex trait are mediated through trans-effects on expression of a relatively sparse set of effector ("core") genes. We tested this hypothesis in a study of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::568808991625cd24212a2ea1bd78ae60
https://doi.org/10.1016/j.ajhg.2023.04.003

Cohort profile:the Scottish Diabetes Research Network national diabetes cohort – a population-based cohort of people with diabetes in Scotland

Autor: Stuart J. McGurnaghan, Luke A. K. Blackbourn, Thomas M. Caparrotta, Joseph Mellor, Anna Barnett, Andy Collier, Naveed Sattar, John McKnight, John Petrie, Sam Philip, Robert Lindsay, Katherine Hughes, David McAllister, Graham P Leese, Ewan R Pearson, Sarah Wild, Paul M McKeigue, Helen M Colhoun

Publikováno v: McGurnaghan, S, Blackbourn, L, Caparrotta, T, Mellor, J, Barnett, A, Collier, A, Sattar, N A, McKnight, J, Petrie, J R, Philip, S, Lindsay, R, Hughes, K, McAllister, D A, Leese, G P, Pearson, E R, Wild, S H, McKeigue, P M & Colhoun, H M 2022, ' Cohort profile : the Scottish Diabetes Research Network national diabetes cohort – a population-based cohort of people with diabetes in Scotland ', BMJ Open, vol. 12, no. 10, e063046 . https://doi.org/10.1136/bmjopen-2022-063046

PurposeThe Scottish Diabetes Research Network (SDRN)-diabetes research platform was established to combine disparate electronic health record data into research-ready linked datasets for diabetes research in Scotland. The resultant cohort, ‘The SDR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c85fb7d7d49679bdd013e78450a84d0d
https://hdl.handle.net/20.500.11820/855b4838-bef0-42f9-bfbf-1e05736bf4df

Relation of incident type 1 diabetes to recent COVID-19 infection: cohort study using e-health record linkage in Scotland

Autor: Paul M. McKeigue, Stuart McGurnaghan, Luke Blackbourn, Louise E. Bath, David A. McAllister, Thomas M. Caparrotta, Sarah H. Wild, Simon N. Wood, Diane Stockton, Helen M. Colhoun

OBJECTIVE Studies using claims databases reported that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection >30 days earlier was associated with an increase in the incidence of type 1 diabetes. Using exact dates of diabetes diagnosi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e04052e0103a53a7cd7924ccd60382cb
https://doi.org/10.2337/figshare.20001458