Zobrazeno 1 - 10
of 186
pro vyhledávání: '"Paul M Loadman"'
Autor:
Helen Marshall, Mark A Hull, David A Cairns, Andrew T Chan, Mingyang Song, Robert Jones, Peter S Hall, Catherine Moriarty, David A Drew, Wendy S Garrett, Giles J Toogood, Paul M Loadman, Andrew J Cockbain, Omer Yilmaz, Pei Loo Ow, Sharon Ruddock, Tim Brend, Alexandra F Smith, Fiona Collinson
Publikováno v:
BMJ Open, Vol 13, Iss 11 (2023)
Introduction There remains an unmet need for safe and cost-effective adjunctive treatment of advanced colorectal cancer (CRC). The omega-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA) is safe, well-tolerated and has anti-inflammatory as wel
Externí odkaz:
https://doaj.org/article/6b799f009e2d4182b03f92a9a5f2e1e9
Autor:
Mark A Hull, Kirsty Sprange, Trish Hepburn, Wei Tan, Aisha Shafayat, Colin J Rees, Gayle Clifford, Richard F Logan, Paul M Loadman, Elizabeth A Williams, Diane Whitham, Alan A Montgomery
Publikováno v:
Efficacy and Mechanism Evaluation, Vol 6, Iss 4 (2019)
Background: The omega-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA) and aspirin both have proof of concept for colorectal cancer (CRC) chemoprevention, aligned with an excellent safety profile. Objectives: The objectives were to determine
Externí odkaz:
https://doaj.org/article/af6edf38b81a43cabcafa96d83b3782a
Autor:
Francis M. Barnieh, Goreti Ribeiro Morais, Paul M. Loadman, Robert A. Falconer, Sherif F. El‐Khamisy
Publikováno v:
Advanced Science, Vol 11, Iss 34, Pp n/a-n/a (2024)
Abstract Targeted therapy remains the future of anti‐cancer drug development, owing to the lack of specificity of current treatments which lead to damage in healthy normal tissues. ATR inhibitors have in recent times demonstrated promising clinical
Externí odkaz:
https://doaj.org/article/89b2cd1dff6344aabd813f0ac8032b72
Autor:
Yousef M J Al-Saraireh, Mark Sutherland, Bradley R Springett, Friedrich Freiberger, Goreti Ribeiro Morais, Paul M Loadman, Rachel J Errington, Paul J Smith, Minoru Fukuda, Rita Gerardy-Schahn, Laurence H Patterson, Steven D Shnyder, Robert A Falconer
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e73366 (2013)
Polysialic acid (polySia), an α-2,8-glycosidically linked polymer of sialic acid, is a developmentally regulated post-translational modification predominantly found on NCAM (neuronal cell adhesion molecule). Whilst high levels are expressed during d
Externí odkaz:
https://doaj.org/article/b3297dba32f944dfb85067dbb3133a97
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38972 (2012)
Tumour invasion and metastasis is the most common cause of death from cancer. For epithelial cells to invade surrounding tissues and metastasise, an epithelial-mesenchymal transition (EMT) is required. We have demonstrated that FGFR1 expression is in
Externí odkaz:
https://doaj.org/article/fcd62f245cff432cb357dcb45532ad61
Autor:
Nicola Ingram, Radwa H. Abou-Saleh, Amanda D. Race, Paul M. Loadman, Richard J. Bushby, Stephen D. Evans, P. Louise Coletta
Publikováno v:
Pharmaceutics, Vol 16, Iss 3, p 434 (2024)
Therapeutic microbubbles (thMBs) contain drug-filled liposomes linked to microbubbles and targeted to vascular proteins. Upon the application of a destructive ultrasound trigger, drug uptake to tumour is improved. However, the structure of thMBs curr
Externí odkaz:
https://doaj.org/article/abff952cecfb4e338f01079ea86da640
Autor:
Nicola Ingram, Laura E. McVeigh, Radwa H. Abou-Saleh, Damien V. B. Batchelor, Paul M. Loadman, James R. McLaughlan, Alexander F. Markham, Stephen D. Evans, P. Louise Coletta
Publikováno v:
Pharmaceutics, Vol 14, Iss 3, p 622 (2022)
Advanced drug delivery systems, such as ultrasound-mediated drug delivery, show great promise for increasing the therapeutic index. Improvements in delivery by altering the ultrasound parameters have been studied heavily in vitro but relatively littl
Externí odkaz:
https://doaj.org/article/102e52c5286745469f1868078ad550f9
Autor:
Heike E. Daldrup-Link, Robert A. Falconer, Paul M. Loadman, Jianghong Rao, Sanjiv Sam Gambhir, Edwin Chang, Samuel Cheshier, Siddharta Mitra, Frederick T. Chin, Laura Pisani, Ketan Yerneni, Jessica Klockow, Goreti Ribeiro Morais, Kai Li, Zixin Chen, Suchismita Mohanty
Glioblastoma (GBM) has a dismal prognosis. Evidence from preclinical tumor models and human trials indicates the role of GBM-initiating cells (GIC) in GBM drug resistance. Here, we propose a new treatment option with tumor enzyme-activatable, combine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6cfde44f0d5475ce85a61715b8ac14d
https://doi.org/10.1158/1535-7163.c.6539568.v1
https://doi.org/10.1158/1535-7163.c.6539568.v1
Autor:
Laurence H. Patterson, Steve D. Shnyder, Klaus Pors, Mark Searcey, Patricia A. Cooper, Mohammed N. Alandas, Nicola A. Illingworth, Helen M. Sheldrake, Jonathan P. Laye, Paul M. Loadman, Jason H. Gill, Mark Sutherland
PDF file - 107K, In vivo metabolic profile of tumour and liver after administration of ICT2700 to CYP1A1 tumor-bearing mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53fa7a3eeadf697425f73382b1b2ff93
https://doi.org/10.1158/1535-7163.22499368.v1
https://doi.org/10.1158/1535-7163.22499368.v1
Autor:
Heike E. Daldrup-Link, Robert A. Falconer, Paul M. Loadman, Jianghong Rao, Sanjiv Sam Gambhir, Edwin Chang, Samuel Cheshier, Siddharta Mitra, Frederick T. Chin, Laura Pisani, Ketan Yerneni, Jessica Klockow, Goreti Ribeiro Morais, Kai Li, Zixin Chen, Suchismita Mohanty
In vivo tumorigenic assay for GIC derived from pcGBM39
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3441a5004eb6b28880d2e511422ec620
https://doi.org/10.1158/1535-7163.22510302.v1
https://doi.org/10.1158/1535-7163.22510302.v1