Biased activity of soluble guanylyl cyclase: the Janus face of thymoquinone

Autor: Charlotte Detremmerie, Paul M. Vanhoutte, Susan Leung

Publikováno v: Acta Pharmaceutica Sinica B, Vol 7, Iss 4, Pp 401-408 (2017)

The natural compound thymoquinone, extracted from Nigella sativa (black cumin), is widely used in humans for its anti-oxidative properties. Thymoquinone is known for its acute endothelium-independent vasodilator effects in isolated rat aortae and pul

Externí odkaz: https://doaj.org/article/301ee618163a463a87a7d4e799ef10fe

Activation of prostaglandin E2-EP4 signaling reduces chemokine production in adipose tissue[S]

Autor: Eva H.C. Tang, Yin Cai, Chi Kin Wong, Viviane Z. Rocha, Galina K. Sukhova, Koichi Shimizu, Ge Xuan, Paul M. Vanhoutte, Peter Libby, Aimin Xu

Publikováno v: Journal of Lipid Research, Vol 56, Iss 2, Pp 358-368 (2015)

Inflammation of adipose tissue induces metabolic derangements associated with obesity. Thus, determining ways to control or inhibit inflammation in adipose tissue is of clinical interest. The present study tested the hypothesis that in mouse adipose

Externí odkaz: https://doaj.org/article/6b1c2f280ab74f8896a51818149a0bbb

Hypoxia, vascular smooth muscles and endothelium

Autor: Calvin K. Chan, Paul M. Vanhoutte

Publikováno v: Acta Pharmaceutica Sinica B, Vol 3, Iss 1, Pp 1-7 (2013)

Hypoxia, or the lack of oxygen, has multiple impacts on the vascular system. The major molecular sensors for hypoxia at the cellular level are hypoxia inducible factor and heme oxygenase. Hypoxia also acts on the vasculature directly conveying its da

Externí odkaz: https://doaj.org/article/8d835be90a204c968ae1acf9ff49567a

TNFα induces endothelial dysfunction in rheumatoid arthritis via LOX-1 and arginase 2: reversal by monoclonal TNFα antibodies

Autor: Giovanni G. Camici, Melroy X. Miranda, Reijo Laaksonen, Simon Kraler, Branko Simic, Jari Metso, Lydia Ntari, Rose Cydecian, Thomas F. Lüscher, Margot Crucet, Matti Jauhiainen, Niki Karagianni, Frank Ruschitzka, Oliver Distler, Adrian Ciurea, Lena Schwarz, Vera Fehr, Luca Liberale, George Kollias, Nicole R. Bonetti, Caroline Ospelt, Alexander Akhmedov, Paul M. Vanhoutte, Mohammad Amrollahi-Sharifabadi, Rita Zilinyi

Aims Rheumatoid arthritis (RA) is a chronic inflammatory disease affecting joints and blood vessels. Despite low levels of low-density lipoprotein cholesterol (LDL-C), RA patients exhibit endothelial dysfunction and are at increased risk of death fro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45cf2066ba84b5281857d3640d6790f4
https://www.zora.uzh.ch/id/eprint/198705/

Natriuretic peptides relax human intrarenal arteries through natriuretic peptide receptor type-A recapitulated by soluble guanylyl cyclase agonists

Autor: Anna Federlein, Boye L. Jensen, Mia Jensen, Kirsten Madsen, Pernille Lund Hansen, Andreas Frees, Paul M. Vanhoutte, Lars Lund, Kasper Bostlund Assersen, Anja Toft

Publikováno v: Frees, A, Assersen, K B, Jensen, M, Hansen, P B L, Vanhoutte, P M, Madsen, K, Federlein, A, Lund, L, Toft, A & Jensen, B L 2021, ' Natriuretic peptides relax human intrarenal arteries through natriuretic peptide receptor type-A recapitulated by soluble guanylyl cyclase agonists ', Acta Physiologica, vol. 231, no. 3, e13565 . https://doi.org/10.1111/apha.13565

Aim: Natriuretic peptides, BNP and ANP increase renal blood flow in experimental animals. The signalling pathway in human kidney vasculature is unknown. It was hypothesized that BNP and ANP cause endothelium-independent relaxation of human intrarenal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aebe085dcdb37485a780ccabe697858
https://findresearcher.sdu.dk:8443/ws/files/175292777/apha.13565.pdf