Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Paul M, Stemmer"'
Autor:
Pankaj Bhatia, Shomaila Mehmood, Nicole Doyon-Reale, Rita Rosati, Paul M. Stemmer, Samson Jamesdaniel
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
IntroductionExposure to heavy metal lead can cause serious health effects such as developmental neurotoxicity in infants, cognitive impairment in children, and cardiovascular and nephrotoxic effects in adults. Hearing loss is one of the toxic effects
Externí odkaz:
https://doaj.org/article/65562c36017b4f90840d21ab505ca44c
Intrinsic sexual dimorphism in the placenta determines the differential response to benzene exposure
Autor:
Anthony Maxwell, Nicholas Adzibolosu, Anna Hu, Yuan You, Paul M. Stemmer, Douglas M. Ruden, Michael C. Petriello, Marianna Sadagurski, Lucas K. Debarba, Lisa Koshko, Jayanth Ramadoss, Annie Thy Nguyen, Darby Richards, Aihua Liao, Gil Mor, Jiahui Ding
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106287- (2023)
Summary: Maternal immune activation (MIA) by environmental challenges is linked to severe developmental complications, such as neurocognitive disorders, autism, and even fetal/maternal death. Benzene is a major toxic compound in air pollution that af
Externí odkaz:
https://doaj.org/article/07b2399baee443fd90afa6f11e1f4297
Autor:
Nicholas J. Carruthers, Clarissa Strieder-Barboza, Joseph A. Caruso, Carmen G. Flesher, Nicki A. Baker, Samuel A. Kerk, Alexander Ky, Anne P. Ehlers, Oliver A. Varban, Costas A. Lyssiotis, Carey N. Lumeng, Paul M. Stemmer, Robert W. O’Rourke
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Dysfunctional visceral adipose tissue (VAT) in obesity is associated with type 2 diabetes (DM) but underlying mechanisms remain unclear. Our objective in this discovery analysis was to identify genes and proteins regulated by DM to elucidate
Externí odkaz:
https://doaj.org/article/024c6a60909c4763a385cab961c87175
Autor:
Chitra Thakur, Yiran Qiu, Qian Zhang, Nicholas J. Carruthers, Miaomiao Yu, Zhuoyue Bi, Yao Fu, Priya Wadgaonkar, Bandar Almutairy, Akimasa Seno, Paul M. Stemmer, Fei Chen
Publikováno v:
iScience, Vol 25, Iss 10, Pp 105057- (2022)
Summary: In this report, we provide evidence showing diminished expression of the mineral dust-induced gene (mdig), a previously identified oncogenic gene, in human triple negative breast cancer (TNBC). Using a mouse model of orthotopic xenograft of
Externí odkaz:
https://doaj.org/article/1c2cbcbf074541f6a44b5dbfde9a3421
Autor:
Sarah A. Keaton, Judy Arnetz, Hikmet Jamil, Abir Dhalimi, Paul M. Stemmer, Douglas M. Ruden, Jolin Yamin, Eric Achtyes, LeAnn Smart, Lena Brundin, Bengt B. Arnetz
Publikováno v:
Comprehensive Psychoneuroendocrinology, Vol 8, Iss , Pp 100097- (2021)
Objective: As the number of refugees continues to rise, there is growing concern about the impact from trauma exposures on their mental health. However, there is a limited understanding of possible biological mechanisms contributing to the substantia
Externí odkaz:
https://doaj.org/article/bfbbef593d654f6abb75579e02927f70
Autor:
Chitra Thakur, Nicholas J. Carruthers, Qian Zhang, Liping Xu, Yao Fu, Zhuoyue Bi, Yiran Qiu, Wenxuan Zhang, Priya Wadgaonkar, Bandar Almutairy, Chunna Guo, Paul M. Stemmer, Fei Chen
Publikováno v:
Biomedicines, Vol 10, Iss 8, p 2021 (2022)
Triple-negative breast cancers are highly aggressive with an overall poor prognosis and limited therapeutic options. We had previously investigated the role of mdig, an oncogenic gene induced by some environmental risk factors, on the pathogenesis of
Externí odkaz:
https://doaj.org/article/c852815b646042c081e4415e3edfb19e
Publikováno v:
Proteomes, Vol 10, Iss 2, p 18 (2022)
Localization of organelle proteins by isotope tagging (LOPIT) maps are a coordinate-directed representation of proteome data that can aid in biological interpretation. Analysis of organellar association for proteins as displayed using LOPIT is evalua
Externí odkaz:
https://doaj.org/article/87856088942044ba87ef78688adf2443
Publikováno v:
BMC Bioinformatics, Vol 19, Iss S14, Pp 13-25 (2018)
Abstract Background The prediction of calmodulin-binding (CaM-binding) proteins plays a very important role in the fields of biology and biochemistry, because the calmodulin protein binds and regulates a multitude of protein targets affecting differe
Externí odkaz:
https://doaj.org/article/2e507eb0be8a4b209b9f0655f39d7f56
Autor:
Bengt B Arnetz, Sukhesh Sudan, Judith E Arnetz, Jolin B Yamin, Mark A Lumley, John S Beck, Paul M Stemmer, Paul Burghardt, Scott E Counts, Hikmet Jamil
Publikováno v:
PLoS ONE, Vol 15, Iss 3, p e0230030 (2020)
BackgroundPsychological war trauma among displaced refugees is an established risk factor for mental health disorders, especially post-traumatic stress disorder (PTSD). Persons with trauma-induced disorders have heightened neuroplastic restructuring
Externí odkaz:
https://doaj.org/article/f1d9a34f5e15482398252486cef218b0
Publikováno v:
Toxics, Vol 10, Iss 2, p 60 (2022)
The hepatic xenobiotic metabolizing enzyme flavin-containing monooxygenase 3 (FMO3) has been implicated in the development of cardiometabolic disease primarily due to its enzymatic product trimethylamine-N oxide (TMAO), which has recently been shown
Externí odkaz:
https://doaj.org/article/4514c1a2db014577b6eadbfb1285bdb6