Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Paul M, Silber"'
Publikováno v:
Chemico-Biological Interactions. 165:165-174
Halobenzenes are ubiquitous environmental contaminants, which are hepatotoxic in both rodents and humans. The molecular mechanism of halobenzene hepatotoxicity was investigated using Quantitative structure-activity relationships (QSAR) and accelerate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58fa5f26db7e00ee8212de8c42e593b1
https://doi.org/10.1016/j.cbi.2006.12.004
https://doi.org/10.1016/j.cbi.2006.12.004
Publikováno v:
Cancer Letters. 214:189-195
A single nucleotide polymorphism in the COMT (catechol-O-methyltransferase) gene that alters the amino acid sequence at codon 108 of S-COMT from val to met (val108met polymorphism) has been associated with a number of diseases and neuropsychiatric di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afbd7fc19be9d4822e9d39d725d57296
https://doi.org/10.1016/j.canlet.2004.06.033
https://doi.org/10.1016/j.canlet.2004.06.033
Autor:
Michael K. McMillian, Cis Van Looveren, Paul M. Silber, Willem Meuldermans, Aruna Koganti, J. Brandon Parker, Mark D. Johnson, Ron A. H. J. Gilissen, Angelique Leone, Geert Mannens, Dirk Roymans
Publikováno v:
Biochemical Pharmacology. 67:427-437
Freshly prepared human hepatocytes are considered as the 'gold standard' for in vitro testing of drug candidates. However, several disadvantages are associated with the use of this model system. The availability of hepatocytes is often low and conseq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97362dba061025ad0c1e1678858be8be
https://doi.org/10.1016/j.bcp.2003.09.022
https://doi.org/10.1016/j.bcp.2003.09.022
Autor:
Scott Lloyd, Andrew Fackett, Yumiko Sakai, Albert P. Li, Nicola J. Hewitt, Michael J Hayden, Paul M. Silber
Publikováno v:
Chemico-Biological Interactions. 142:57-71
We report here our studies on troglitazone and rosiglitazone cytotoxicity in human hepatocytes isolated from multiple donors to investigate factors responsible for individual differences in sensitivity to the known hepatotoxicity of these antidiabeti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdbf170849b9578a4efb0f34bf97911b
https://doi.org/10.1016/s0009-2797(02)00054-6
https://doi.org/10.1016/s0009-2797(02)00054-6
Autor:
Julie A Brent, Andrew Fackett, Albert P. Li, Chuang Lu, Chuong Pham, Charles E. Ruegg, Paul M. Silber
Publikováno v:
Chemico-Biological Interactions. 121:17-35
Cryopreserved human hepatocytes were extensively characterized in our laboratory. The post-thaw viability, measured via dye exclusion, ranged from 55 to 83%, for hepatocytes cryopreserved from 17 donors. Post-thaw viability and yield (viable cells pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::676c39d1e1118a8e5f44ce4d8f4bcc6f
https://doi.org/10.1016/s0009-2797(99)00088-5
https://doi.org/10.1016/s0009-2797(99)00088-5
Autor:
Heather Eng, Ritwik Ghosh, Paul M. Silber, James P. Byers, Genfu Chen, Donald B. White, Anand Katta, Nicola J. Hewitt, Kenneth Bachmann
Publikováno v:
Drug metabolism letters. 1(2)
Cryopreserved human hepatocytes in suspension were used to estimate in vivo hepatic clearances for six different drugs. In vitro intrinsic clearances were measured on the basis of substrate depletion. The number of different hepatocyte donors require
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83db9d3fe65044af187eb1256cad2b8e
https://pubmed.ncbi.nlm.nih.gov/19356026
https://pubmed.ncbi.nlm.nih.gov/19356026
Autor:
Paul M. Silber, Nicola J. Hewitt, Nadège Blanchard, Hannah M. Jones, Thierry Lavé, Philippe Coassolo
Publikováno v:
The Journal of pharmacy and pharmacology. 58(5)
Cryopreserved human hepatocytes have been used to predict hepatic in-vivo clearance. Physiologically-based direct scaling methods generally underestimate human in-vivo hepatic clearance. Cryopreserved human hepatocytes were incubated in 100% serum an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14be7d38012f5447fed7848d6eced822
https://pubmed.ncbi.nlm.nih.gov/16640832
https://pubmed.ncbi.nlm.nih.gov/16640832
Autor:
Lanika A, Brown, Linda M, Arterburn, Ana P, Miller, Nancy L, Cowger, Sonya M, Hartley, Annette, Andrews, Paul M, Silber, Albert P, Li
Publikováno v:
In vitro cellulardevelopmental biology. Animal. 39(1-2)
Rat hepatocytes were cultured initially as spheroids on culture plates and then transferred into a rotating wall vessel (high-aspect ratio vessel [HARV]) for further culturing. Morphological evaluation based on electron microscopy showed that hepatoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0a86e7d4e85fcb5faf5407d06adc91a8
https://pubmed.ncbi.nlm.nih.gov/12892522
https://pubmed.ncbi.nlm.nih.gov/12892522
Autor:
Linda M. Arterburn, Ana P. Miller, Sonya M. Hartley, Lanika A. Brown, Annette Andrews, Albert P. Li, Nancy L. Cowger, Paul M. Silber
Publikováno v:
In Vitro Cellular and Developmental Biology-Animal.
Rat hepatocytes were cultured initially as spheroids on culture plates and then transferred into a rotating wall vessel (high-aspect ratio vessel [HARV]) for further culturing. Morphological evaluation based on electron microscopy showed that hepatoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::253a67ddcecc5a8ee3c1d829f4956e5c
https://doi.org/10.1290/020604
https://doi.org/10.1290/020604
Autor:
Saileta Prabhu, Scott Lloyd, Paul M. Silber, Holly A McClellan, Albert P. Li, Andrew Fackett, Chris M Terrell
Publikováno v:
Chemico-biological interactions. 142(1-2)
Troglitazone (TGZ) is an orally active antihyperglycemic agent used in the treatment of noninsulin-dependent diabetes mellitus. Several cases of liver failure following TGZ administration led to its withdrawal from the market. The mechanism of toxici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c7f63c9a3c37ad17cd419130f28461c
https://pubmed.ncbi.nlm.nih.gov/12399157
https://pubmed.ncbi.nlm.nih.gov/12399157