Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Paul M, Levine"'
Publikováno v:
Journal of Medicinal Chemistry. 65:11913-11926
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::460e2e12e68ea3bd1e6d32fab7a5c548
https://doi.org/10.1021/acs.jmedchem.2c01077
https://doi.org/10.1021/acs.jmedchem.2c01077
Autor:
Erin C. Yang, Robby Divine, Marcos C. Miranda, Andrew J. Borst, Will Sheffler, Jason Z Zhang, Justin Decarreau, Amijai Saragovi, Mohamad Abedi, Nicolas Goldbach, Maggie Ahlrichs, Craig Dobbins, Alexis Hand, Suna Cheng, Mila Lamb, Paul M. Levine, Sidney Chan, Rebecca Skotheim, Jorge Fallas, George Ueda, Joshua Lubner, Masaharu Somiya, Alena Khmelinskaia, Neil P. King, David Baker
Publikováno v:
bioRxiv
Programming protein nanomaterials to respond to changes in environmental conditions is a current challenge for protein design and important for targeted delivery of biologics. We describe the design of octahedral non-porous nanoparticles with the thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08485ba26a36e4b67dd39fd83b59e0cd
https://doi.org/10.1101/2023.04.17.537263
https://doi.org/10.1101/2023.04.17.537263
Autor:
Paul M. Levine, Timothy W. Craven, Xinting Li, Aaron T. Balana, Gregory H. Bird, Marina Godes, Patrick J. Salveson, Patrick W. Erickson, Mila Lamb, Maggie Ahlrichs, Michael Murphy, Cassandra Ogohara, Meerit Y. Said, Loren D. Walensky, Matthew R. Pratt, David Baker
Publikováno v:
ACS Chem Biol
Peptide and protein bioconjugation technologies have revolutionized our ability to site-specifically or chemoselectively install a variety of functional groups for applications in chemical biology and medicine, including the enhancement of bioavailab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b694595cf409370fd01594d28a8eb682
https://pubmed.ncbi.nlm.nih.gov/35319882
https://pubmed.ncbi.nlm.nih.gov/35319882
Autor:
Michael J. Garabedian, Kent Kirshenbaum, Susan K. Logan, Keren Imberg-Kazdan, Michael Haugbro, Adam A. Profit, Paul M. Levine, Dilani C. Dehigaspitiya, Yu Wang
Development of resistance to antiandrogens for treating advanced prostate cancer is a growing concern and extends to recently developed therapeutics, including enzalutamide. Therefore, new strategies to block androgen receptor (AR) function in prosta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9faf706199423a4796009a5c110da5a9
https://doi.org/10.1158/0008-5472.c.6508194.v1
https://doi.org/10.1158/0008-5472.c.6508194.v1
Autor:
Michael J. Garabedian, Kent Kirshenbaum, Susan K. Logan, Keren Imberg-Kazdan, Michael Haugbro, Adam A. Profit, Paul M. Levine, Dilani C. Dehigaspitiya, Yu Wang
Primer sequences for qRT-PCR.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1906527970707a30c62142ca681d2855
https://doi.org/10.1158/0008-5472.22411314.v1
https://doi.org/10.1158/0008-5472.22411314.v1
Autor:
Michael J. Garabedian, Kent Kirshenbaum, Susan K. Logan, Keren Imberg-Kazdan, Michael Haugbro, Adam A. Profit, Paul M. Levine, Dilani C. Dehigaspitiya, Yu Wang
MPC6 inhibits AR transcriptional activity (S1); MPC6 treatment did not decrease AR protein level in prostate cancer cell lines (S2); MPC6's anti-proliferative effect in non-prostate cancer cell lines (S3); PK/PD analysis for plasma MPC6 concentration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b61ca73741d70ea8fdb21dadc1554c0e
https://doi.org/10.1158/0008-5472.22411320
https://doi.org/10.1158/0008-5472.22411320
Autor:
Michael J. Garabedian, Kent Kirshenbaum, Susan K. Logan, Keren Imberg-Kazdan, Michael Haugbro, Adam A. Profit, Paul M. Levine, Dilani C. Dehigaspitiya, Yu Wang
IC50 of enzalutamide and MPC6 in prostate cancer cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::430d72d21bfdb06aafb16e22faa5692d
https://doi.org/10.1158/0008-5472.22411317.v1
https://doi.org/10.1158/0008-5472.22411317.v1
Autor:
Florian Praetorius, Philip J. Y. Leung, Maxx H. Tessmer, Adam Broerman, Cullen Demakis, Acacia F. Dishman, Arvind Pillai, Abbas Idris, David Juergens, Justas Dauparas, Xinting Li, Paul M. Levine, Mila Lamb, Ryanne K. Ballard, Stacey R. Gerben, Hannah Nguyen, Alex Kang, Banumathi Sankaran, Asim K. Bera, Brian F. Volkman, Jeff Nivala, Stefan Stoll, David Baker
Proteins that switch between two structural states as a function of environmental stimuli are widespread in nature. These proteins structurally transduce biochemical information in a manner analogous to how transistors control information flow in com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ffd869139e74a9969afeb1fde7c1d01
https://doi.org/10.1101/2023.01.27.525968
https://doi.org/10.1101/2023.01.27.525968
Autor:
Susana Vázquez Torres, Philip J. Y. Leung, Isaac D. Lutz, Preetham Venkatesh, Joseph L. Watson, Fabian Hink, Huu-Hien Huynh, Andy Hsien-Wei Yeh, David Juergens, Nathaniel R. Bennett, Andrew N. Hoofnagle, Eric Huang, Michael J MacCoss, Marc Expòsit, Gyu Rie Lee, Paul M. Levine, Xinting Li, Mila Lamb, Elif Nihal Korkmaz, Jeff Nivala, Lance Stewart, Joseph M. Rogers, David Baker
Many peptide hormones form an alpha-helix upon binding their receptors1–4, and sensitive detection methods for them could contribute to better clinical management.De novoprotein design can now generate binders with high affinity and specificity to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1f71e8af52449b591ee281d1a65d41b
https://doi.org/10.1101/2022.12.10.519862
https://doi.org/10.1101/2022.12.10.519862
Publikováno v:
Journal of medicinal chemistry. 65(18)
Cyclic peptides are among the most diverse architectures for current drug discovery efforts. Their size, stability, and ease of synthesis provide attractive scaffolds to engage and modulate some of the most challenging targets, including protein-prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5b0976d0ef426ba3f08e32a12d3f689b
https://pubmed.ncbi.nlm.nih.gov/36074956
https://pubmed.ncbi.nlm.nih.gov/36074956