Zobrazeno 1 - 10
of 245
pro vyhledávání: '"Paul M, Kaye"'
Autor:
Madhurima Roy, Ritika Sengupta, Bidhan Chandra Chakraborty, Uttara Chatterjee, Esther von Stebut, Paul M Kaye, Mitali Chatterjee
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 18, Iss 11, p e0012655 (2024)
BackgroundPost Kala-azar Dermal Leishmaniasis (PKDL) is a dermal sequel of visceral leishmaniasis (VL), poses a significant threat to the success of ongoing kala-azar elimination program, due to its potential role in sustaining transmission cycles an
Externí odkaz:
https://doaj.org/article/cbceca4f978040bebf9e2ea7c6a9ce22
Autor:
Max C Waugh, Karen I Cyndari, Tom J Lynch, Soomin Koh, Ferney Henao-Ceballos, Jacob J Oleson, Paul M Kaye, Christine A Petersen
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 18, Iss 11, p e0012363 (2024)
Dogs represent the primary reservoir for Leishmania infantum human visceral leishmaniasis (VL) transmitted through phlebotomine sand flies. Public health initiatives targeting zoonotic VL commonly focus on dogs with severe clinical disease, often in
Externí odkaz:
https://doaj.org/article/c5a3c2e2613d4fd5afbd0789e148f6c3
Autor:
Brima M. Younis, Rebecca Wiggins, Eltahir A.G. Khalil, Mohamed Osman, Francesco Santoro, Chiara Sonnati, Ada Keding, Maria Novedrati, Giorgio Montesi, Ali Noureldein, Elmukashfi T.A. Elmukashfi, Ala Eldin Mustafa, Mohammed Alamin, Mohammed Saeed, Khalid Salman, Ahmed J. Suliman, Amin E.A. Musa, Alison M. Layton, Charles J.N. Lacey, Paul M. Kaye, Ahmed M. Musa
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 3, Pp 101310- (2024)
In a recent phase 2a clinical trial, the candidate leishmaniasis vaccine ChAd63-KH was shown to be safe and immunogenic in Sudanese patients with post kala-azar dermal leishmaniasis (PKDL). However, its value as a stand-alone therapeutic was unknown.
Externí odkaz:
https://doaj.org/article/a583923d15cf4d3cb40a6f85f30978df
Autor:
Luke Milross, Bethany Hunter, David McDonald, George Merces, Amanda Thomson, Catharien M.U. Hilkens, John Wills, Paul Rees, Kasim Jiwa, Nigel Cooper, Joaquim Majo, Helen Ashwin, Christopher J.A. Duncan, Paul M. Kaye, Omer Ali Bayraktar, Andrew Filby, Andrew J. Fisher
Publikováno v:
EBioMedicine, Vol 99, Iss , Pp 104945- (2024)
Summary: Background: Lung damage in severe COVID-19 is highly heterogeneous however studies with dedicated spatial distinction of discrete temporal phases of diffuse alveolar damage (DAD) and alternate lung injury patterns are lacking. Existing studi
Externí odkaz:
https://doaj.org/article/1b7f1a779bc24e5da70f8643842a6531
Autor:
Roel Tans, Shoumit Dey, Nidhi Sharma Dey, Jian-Hua Cao, Prasanjit S. Paul, Grant Calder, Peter O’Toole, Paul M. Kaye, Ron M. A. Heeren
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
IntroductionSpatial analysis of lipids in inflammatory microenvironments is key to understand the pathogenesis of infectious disease. Granulomatous inflammation is a hallmark of leishmaniasis and changes in host and parasite lipid metabolism have bee
Externí odkaz:
https://doaj.org/article/3fc2fac6fab04f08a4fd9e1e0d0cb1b9
Autor:
Helen Ashwin, Jovana Sadlova, Barbora Vojtkova, Tomas Becvar, Patrick Lypaczewski, Eli Schwartz, Elizabeth Greensted, Katrien Van Bocxlaer, Marion Pasin, Kai S. Lipinski, Vivak Parkash, Greg Matlashewski, Alison M. Layton, Charles J. Lacey, Charles L. Jaffe, Petr Volf, Paul M. Kaye
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Controlled human infection models (CHIMs) provide a pathway for accelerating vaccine development. Here, the authors describe the isolation, characterization, and GMP manufacture of a clinical Leishmania major strain to be used as a resource for CHIM
Externí odkaz:
https://doaj.org/article/ddd377d986694040985714870d5c4e1c
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 16, Iss 6, p e0010471 (2022)
BackgroundA pressing need exists to develop vaccines for neglected diseases, including leishmaniasis. However, the development of new vaccines is dependent on their value to two key players-vaccine developers and manufacturers who need to have confid
Externí odkaz:
https://doaj.org/article/cafe4e543d4a4b16bcd27ef76dee66c8
Autor:
Sarah Forrester, Amy Goundry, Bruna Torres Dias, Thyago Leal-Calvo, Milton Ozório Moraes, Paul M. Kaye, Jeremy C. Mottram, Ana Paula C. A. Lima
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 2 (2022)
ABSTRACT Visceral leishmaniasis is associated with hepato-splenomegaly and altered immune and hematological parameters in both preclinical animal models and humans. We studied mouse experimental visceral leishmaniasis caused by Leishmania infantum an
Externí odkaz:
https://doaj.org/article/f8e33324c0cf47c68037d65da0732fd3
Autor:
Anna Simon, Ming Yang, Joanne L. Marrison, Andrew D. James, Mark J. Hunt, Peter J. O’Toole, Paul M. Kaye, Miles A. Whittington, Sangeeta Chawla, William J. Brackenbury
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-15 (2020)
Abstract Background An emerging problem in the treatment of breast cancer is the increasing incidence of metastases to the brain. Metastatic brain tumours are incurable and can cause epileptic seizures and cognitive impairment, so better understandin
Externí odkaz:
https://doaj.org/article/83744fe99058415e8571e6153d33ff04
Autor:
Eliza Vanessa Carneiro Alves-Ferreira, Tiago Rodrigues Ferreira, Pegine Walrad, Paul M. Kaye, Angela Kaysel Cruz
Publikováno v:
Parasites & Vectors, Vol 13, Iss 1, Pp 1-11 (2020)
Abstract Background Prostaglandins (PG) are lipid mediators derived from arachidonic acid metabolism. They are involved in cellular processes such as inflammation and tissue homeostasis. PG production is not restricted to multicellular organisms. Try
Externí odkaz:
https://doaj.org/article/ca0c3010cb1643e0bb93bcb7ca300d22