Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Paul M, Fitch"'
Autor:
Silke M Currie, Emily Gwyer Findlay, Brian J McHugh, Annie Mackellar, Tian Man, Derek Macmillan, Hongwei Wang, Paul M Fitch, Jürgen Schwarze, Donald J Davidson
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e73659 (2013)
Respiratory syncytial virus is a leading cause of lower respiratory tract illness among infants, the elderly and immunocompromised individuals. Currently, there is no effective vaccine or disease modifying treatment available and novel interventions
Externí odkaz:
https://doaj.org/article/6bc4431fc09a4e508c8c07a5dfaab2b8
Autor:
Jürgen Schwarze, Emily Gwyer Findlay, Allan Paras, Agnieszka Jozwik, Amanda J. McFarlane, Christopher Chiu, Nick Colegrave, Donald J. Davidson, Paul M. Fitch, Silke M. Currie, Bettina Böttcher
Publikováno v:
The Journal of Immunology Author Choice
Currie, S M, Gwyer Findlay, E, McFarlane, A, Fitch, P, Boettcher, A, Colegrave, N, Paras, A, Jozwik, A, Chiu, C, Schwarze, J & Davidson, D J 2016, ' Cathelicidins have direct antiviral activity against respiratory syncytial virus in vitro and protective function in vivo in mice and humans. ', Journal of Immunology, vol. 196, no. 6, pp. 2699-2710 . https://doi.org/10.4049/jimmunol.1502478
Currie, S M, Gwyer Findlay, E, McFarlane, A, Fitch, P, Boettcher, A, Colegrave, N, Paras, A, Jozwik, A, Chiu, C, Schwarze, J & Davidson, D J 2016, ' Cathelicidins have direct antiviral activity against respiratory syncytial virus in vitro and protective function in vivo in mice and humans. ', Journal of Immunology, vol. 196, no. 6, pp. 2699-2710 . https://doi.org/10.4049/jimmunol.1502478
Respiratory syncytial virus (RSV) is a leading cause of respiratory tract infection in infants, causing significant morbidity and mortality. No vaccine or specific, effective treatment is currently available. A more complete understanding of the key
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dbe88c17e90ab2dd9324d22ce75a4ac
http://europepmc.org/articles/PMC4777919
http://europepmc.org/articles/PMC4777919
Publikováno v:
Faluyi, O O, Fitch, P & Howie, S 2017, ' An increased CD25-positive intestinal regulatory T-lymphocyte population is dependent on Cox-2 activity in the Apc Min/+ model ', Clinical & Experimental Immunology . https://doi.org/10.1111/cei.13055
Summary Only mismatch repair (MMR)-deficient colorectal cancer (CRC) appears to respond well to programmed death (PD)-1 inhibition at the present time. Emerging evidence suggests a role for micro-environmental factors such as CD25+ cells modulating r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::724d9335fd668c9a022f0ba5f3a95fae
https://hdl.handle.net/20.500.11820/733f9c7a-2477-453a-91e4-d9b03ba03cb2
https://hdl.handle.net/20.500.11820/733f9c7a-2477-453a-91e4-d9b03ba03cb2
Autor:
Harold G. de Bruin, Jürgen Schwarze, Maarten van den Berge, Paul M. Fitch, Claire Errington, Reina Matsuda, J. Heimweg, Antoon J. M. van Oosterhout, Irene H. Heijink
Publikováno v:
European Respiratory Journal, 48(6), 1785-1788. EUROPEAN RESPIRATORY SOC JOURNALS LTD
Schwarze, J, Fitch, P, Heimweg, J, Errington, C, Matsuda, R, de Bruin, H G, van der Berge, M, van Oosterhout, A J M & Heijink, I H 2016, ' Viral mimic poly-(I:C) attenuates airway epithelial T cell suppressive capacity; implications for asthma ', European Respiratory Journal . https://doi.org/10.1183/13993003.00841-2016
Schwarze, J, Fitch, P, Heimweg, J, Errington, C, Matsuda, R, de Bruin, H G, van der Berge, M, van Oosterhout, A J M & Heijink, I H 2016, ' Viral mimic poly-(I:C) attenuates airway epithelial T cell suppressive capacity; implications for asthma ', European Respiratory Journal . https://doi.org/10.1183/13993003.00841-2016
In allergen-sensitised asthmatic individuals, allergen-specific type-2 T-helper cells proliferate and secrete type-2 cytokines (e.g. interleukin (IL)-4, -5 and -13), driving the airway inflammatory response that gives rise to the clinical symptoms of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca5dfe0c970ebe4c36fb1d1e9185a040
https://research.rug.nl/en/publications/34079217-aa5a-42ee-af00-33789e04d783
https://research.rug.nl/en/publications/34079217-aa5a-42ee-af00-33789e04d783
Autor:
Sarah E. M. Howie, Paul M. Fitch, Stephen M. Anderton, Jürgen Schwarze, Claire Wilson, Anne Ilchmann, Karen J. Mackenzie, Amanda J. McFarlane, Melanie D. Leech
Publikováno v:
Immunology. 138:258-268
Peptide immunotherapy using soluble peptides containing allergen‐derived immunodominant T‐cell epitopes holds therapeutic promise for allergic asthma. Previous studies in BALB/c mice using the immunodominant peptide epitope of chicken ovalbumin (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e41d48f47ed99f32e84f93421eca01d1
https://doi.org/10.1111/imm.12032
https://doi.org/10.1111/imm.12032
Respiratory and gastrointestinal epithelial modulation of the immune response during viral infection
Publikováno v:
Innate Immunity. 18:179-189
Respiratory and enteric viral infections cause significant morbidity and mortality world-wide and represent a major socio-economic burden. Many of these viruses have received unprecedented public and media interest in recent years. A popular public m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a975033dd104d3f1d842550bb0b5fb34
https://doi.org/10.1177/1753425910391826
https://doi.org/10.1177/1753425910391826
Publikováno v:
International Journal of Experimental Pathology. 92:8-17
Idiopathic interstitial lung diseases (iILDs) are characterized by inflammation, hyperplasia of Type-II alveolar epithelial cells (AECs) and lung remodelling often with progressive fibrosis. It remains unclear which signals initiate iILD and/or maint
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92f3b21eefb9f9fdd40e7b0fcb1e957b
https://doi.org/10.1111/j.1365-2613.2010.00743.x
https://doi.org/10.1111/j.1365-2613.2010.00743.x
Autor:
Enrico Beccastrini, Sergio Romagnani, Antonio Guarna, Francesca Nencini, Annick deVries, Paola Parronchi, Cinzia Manuelli, Paola Fanti, Daniele Bani, Lucia Filì, Alessandra Vultaggio, Sarah E. M. Howie, Maria Grazia Giudizi, Laura Maggi, Francesco Annunziato, Francesca Palandri, Enrico Maggi, Paul M. Fitch
Publikováno v:
The Journal of Immunology. 182:880-889
Substitute adenine (SA)-2, a synthetic heterocycle chemically related to adenine with substitutions in positions 9-, 2-, and 8- (i.e., 9-benzyl-2-butoxy-8-hydroxyadenine), induces in vitro immunodeviation of Th2 cells to a Th0/Th1 phenotype. In this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abe41a735805bfd3250836ce6172ae86
https://doi.org/10.4049/jimmunol.182.2.880
https://doi.org/10.4049/jimmunol.182.2.880
Differential lower airway dendritic cell patterns may reveal distinct endotypes of RSV bronchiolitis
Autor:
Paul M. Fitch, Jon McCormack, Liz Waxman, Armin Braun, Richard Levin, Jürgen Schwarze, Sabine Wronski, Claire Errington, Ulf Theilen, Aoife Kerrin, Karen J. Mackenzie, Kay Riding, Henry J. McSorley, Dennis Kerr, Felicity Mehendele
Publikováno v:
Kerrin, A, Fitch, P, Errington, C, Kerr, D, Waxman, L, Riding, K, McCormack, J, Mehendale, F, McSorley, H, Mackenzie, K, Wronski, S, Braun, A, Leven, R, Theilen, U & Schwarze, J 2017, ' Differential lower airway dendritic cell patterns may reveal distinct endotypes of RSV bronchiolitis ', Thorax, vol. 72, no. 7, pp. 620-627 . https://doi.org/10.1136/thoraxjnl-2015-207358
Rationale The pathogenesis of respiratory syncytial virus (RSV) bronchiolitis in infants remains poorly understood. Mouse models implicate pulmonary T cells in the development of RSV disease. T cell responses are initiated by dendritic cells (DCs), w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb62bb03aa16ef8e21374d759d94c9f6
https://pubmed.ncbi.nlm.nih.gov/27531529
https://pubmed.ncbi.nlm.nih.gov/27531529
Autor:
Claire S, Leitch, Eenass, Natafji, Cunjing, Yu, Sharizan, Abdul-Ghaffar, Nayani, Madarasingha, Zoë C, Venables, Roland, Chu, Paul M, Fitch, Andrew J, Muinonen-Martin, Linda E, Campbell, W H Irwin, McLean, Jürgen, Schwarze, Sarah E M, Howie, Richard B, Weller
Publikováno v:
The Journal of Allergy and Clinical Immunology
Background Mutations in the gene encoding filaggrin (FLG), an epidermal structural protein, are the strongest risk factor identified for the development of atopic dermatitis (AD). Up to 50% of patients with moderate-to-severe AD in European populatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7e228d316d720812b62b5f9b5ccad3a9
https://pubmed.ncbi.nlm.nih.gov/26934939
https://pubmed.ncbi.nlm.nih.gov/26934939