Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Paul Lohan"'
Autor:
Oliver Treacy, Kevin Lynch, Nick Murphy, Xizhe Chen, Ellen Donohoe, Aoife Canning, Paul Lohan, Georgina Shaw, Gerry Fahy, Aideen E. Ryan, Thomas Ritter
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-9 (2021)
Abstract Background Systemic administration of mesenchymal stromal cells (MSCs) has been efficacious in many inflammatory disease settings; however, little data are available on the potential immunomodulatory effects following local MSC administratio
Externí odkaz:
https://doaj.org/article/3b79d25cdb3f469fbeae7ed535e1e9c6
Autor:
Paul Lohan, Nick Murphy, Oliver Treacy, Kevin Lynch, Maurice Morcos, Bingling Chen, Aideen E. Ryan, Matthew D. Griffin, Thomas Ritter
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
High-risk cornea transplant recipients represent a patient population with significant un-met medical need for more effective therapies to prevent immunological graft rejection due to heightened anti-donor immune response. In this study, a rat model
Externí odkaz:
https://doaj.org/article/22857e7084cd481a9d3298175837b2ae
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Mesenchymal stromal cells (MSC) have been used to treat a broad range of disease indications such as acute and chronic inflammatory disorders, autoimmune diseases, and transplant rejection due to their potent immunosuppressive/anti-inflammatory prope
Externí odkaz:
https://doaj.org/article/049c409f88fa4cd8b33bc753825f22e0
Autor:
Kevin Lynch, Oliver Treacy, Jared Q. Gerlach, Heidi Annuk, Paul Lohan, Joana Cabral, Lokesh Joshi, Aideen E. Ryan, Thomas Ritter
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Dendritic cellular therapies and dendritic cell vaccines show promise for the treatment of autoimmune diseases, the prolongation of graft survival in transplantation, and in educating the immune system to fight cancers. Cell surface glycosylation pla
Externí odkaz:
https://doaj.org/article/c051dc13a8074112acb9a9d2ad2a5a0d
Autor:
Oliver Treacy, Aideen E Ryan, Teresa Heinzl, Lisa O'Flynn, Marese Cregg, Mieszko Wilk, Francesca Odoardi, Paul Lohan, Timothy O'Brien, Mikhail Nosov, Thomas Ritter
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42662 (2012)
Adult mesenchymal stem cells (MSCs) are non-hematopoietic cells with multi-lineage potential which makes them attractive targets for regenerative medicine applications. However, to date, therapeutic success of MSC-therapy is limited and the genetic m
Externí odkaz:
https://doaj.org/article/55d431c8d85e47059b111fe8ebca5251
Autor:
Aideen E. Ryan, Laurence J. Egan, Thomas Ritter, Philip D. Dunne, Paul Lohan, Niamh A. Leonard, Serika D. Naicker, Kevin Lynch, Oliver Treacy, Grace O'Malley
Characterisation of primary BALB/c MSCs isolated from bone marrow, PD-L1 induction on MSC TNF-TCM is dependent on CT26 NF-κB activity, Validation of scrambled and PD-L1 shRNA transduced Balb/c MSCs - GFP expression and PD-L1 inhibition, Tumour burde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86a61c546552ef02c383997114c02e32
https://doi.org/10.1158/2326-6066.22538954.v1
https://doi.org/10.1158/2326-6066.22538954.v1
Autor:
Aideen E. Ryan, Laurence J. Egan, Thomas Ritter, Philip D. Dunne, Paul Lohan, Niamh A. Leonard, Serika D. Naicker, Kevin Lynch, Oliver Treacy, Grace O'Malley
Stromal cells of mesenchymal origin reside below the epithelial compartment and provide structural support in the intestine. These intestinal stromal cells interact with both the epithelial cell compartments, as well as infiltrating hematopoietic imm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ab876094850beb1c442bcdf4ca86e13
https://doi.org/10.1158/2326-6066.c.6548954.v1
https://doi.org/10.1158/2326-6066.c.6548954.v1
Autor:
Matthew D. Griffin, Oliver Treacy, Thomas Ritter, Nahidul Islam, Nick Murphy, Kevin Lynch, Steven McLoughlin, Paul Lohan, Luke Watson, Ellen Donohoe, Grace O’Malley, Xizhe Chen, Aideen E. Ryan
Publikováno v:
Molecular Therapy
Mesenchymal stromal cells (MSCs) are a promising therapeutic option for multiple immune diseases/disorders; however, efficacy of MSC treatments can vary significantly. We present a novel licensing strategy to improve the immunosuppressive capacity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb2eee4e6cb6994a71f4aefd6e74b2ab
https://doi.org/10.1016/j.ymthe.2020.05.023
https://doi.org/10.1016/j.ymthe.2020.05.023
Autor:
Thomas Ritter, Aideen E. Ryan, Oliver Treacy, Nick Murphy, Kevin Lynch, Linda Howard, Paul Lohan, Matthew D. Griffin, Gerry Fahy, Maurice Morcos
Publikováno v:
The FASEB Journal. 33:9404-9421
Mesenchymal stromal cells (MSCs) have shown promise as a therapy for immune-mediated disorders, including transplant rejection. Our group previously demonstrated the efficacy of pretransplant, systemic administration of allogeneic but not syngeneic M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8eedb9317c78182a1f4076d1e0a52a7
https://doi.org/10.1096/fj.201900047r
https://doi.org/10.1096/fj.201900047r
Autor:
Philip D Dunne, Oliver Treacy, Serika D. Naicker, Laurence J. Egan, Aideen E. Ryan, Grace O’Malley, Kevin Lynch, Paul Lohan, Thomas Ritter, Niamh A Leonard
Publikováno v:
Cancer Immunology Research. 6:1426-1441
Stromal cells of mesenchymal origin reside below the epithelial compartment and provide structural support in the intestine. These intestinal stromal cells interact with both the epithelial cell compartments, as well as infiltrating hematopoietic imm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::508c3cb33cd706fad3db5b381b91bb06
https://doi.org/10.1158/2326-6066.cir-17-0443
https://doi.org/10.1158/2326-6066.cir-17-0443