Dysregulation of Circadian Rhythm Gene Expression in Cystic Fibrosis Mice

Autor: Eric Barbato, Hannah Mianzo, Paul Litman, Rebecca Darrah

Publikováno v: Journal of Circadian Rhythms, Vol 17, Iss 1 (2019)

Cystic fibrosis (CF) is autosomal recessive disease that affects multiple body systems. CF patients often experience sleep disturbances, altered sleep patterns, and sleep apnea. Sleep in mammals is controlled in part by circadian clock genes, includi

Externí odkaz: https://doaj.org/article/08796973e9b547d7b5526e1c214bea39

Genetic Correlates of Fatigue in Individuals with End Stage Renal Disease

Autor: Paul Litman, Niraj B Desai, Christine Horvat Davey, Rebecca J. Darrah, Allison R. Webel, Joachim G. Voss, Chao-Pin Hsiao, Ashwini R. Sehgal, Federico Perez

Publikováno v: Western Journal of Nursing Research. 42:1042-1049

Fatigue is a prevalent symptom associated with decreased quality of life and increased mortality in individuals with end stage renal disease (ESRD), yet causes of fatigue in individuals with ESRD remain poorly understood. We examined gene expression

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af814752d52fb10cf40d480631806b2f
https://doi.org/10.1177/0193945920919911

Genetic Variation Near chrXq22-q23 Is Linked to Emotional Functioning in Cystic Fibrosis

Autor: Eric Barbato, Mary Kerr, Sara L. Douglas, Paul Litman, Barbara J. Daly, Rebecca J. Darrah

Publikováno v: Biol Res Nurs

Introduction: Cystic fibrosis (CF) is an autosomal recessive disease that affects many organ systems, most notably the pulmonary and gastrointestinal systems. Through genome-wide association studies, multiple genetic regions modifying CF-related pulm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a58161a162a453d51452d91cb8c250e
https://pubmed.ncbi.nlm.nih.gov/32390518

AGTR2 absence or antagonism prevents cystic fibrosis pulmonary manifestations

Autor: Garry R. Cutting, David E. Nethery, Mitchell L. Drumm, Eric Barbato, Neha Joshi, Paul Litman, Cara Campanaro, Abdus Sattar, Rebecca J. Darrah, Michael R. Knowles, Frank J. Jacono, Lisa J. Strug, Craig A. Hodges, Anna L. Mitchell, Harriet Corvol, Jennifer Frey

Publikováno v: Journal of Cystic Fibrosis
Journal of Cystic Fibrosis, 2019, 18 (1), pp.127-134. ⟨10.1016/j.jcf.2018.05.013⟩
Journal of Cystic Fibrosis, Elsevier, 2019, 18 (1), pp.127-134. ⟨10.1016/j.jcf.2018.05.013⟩

International audience; BACKGROUND: Pulmonary disease remains the primary cause of morbidity and mortality for individuals with cystic fibrosis (CF). Variants at a locus on the X-chromosome containing the type 2 angiotensin II receptor gene (AGTR2) w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4164aed56a6f38eab59d091222ea319
https://hal.sorbonne-universite.fr/hal-02041563

COMMD1 interacts with the COOH terminus of NKCC1 in Calu-3 airway epithelial cells to modulate NKCC1 ubiquitination

Autor: Carole M. Liedtke, Laura Smith, Paul Litman

Publikováno v: American Journal of Physiology-Cell Physiology. 305:C133-C146

Mice deficient in Na-K-2Cl cotransporter (NKCC1) have been generated by targeted disruption of the gene encoding NKCC1 involving the carboxy terminus (CT-NKCC1) but not the amino terminus. We hypothesize that the resulting physiological defects are d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d01d6b8da86726a76a5206e00aa732d
https://doi.org/10.1152/ajpcell.00394.2012