Structural insights into recognition of chemokine receptors by Staphylococcus aureus leukotoxins

Autor: Paul Lambey, Omolade Otun, Xiaojing Cong, François Hoh, Luc Brunel, Pascal Verdié, Claire M Grison, Fanny Peysson, Sylvain Jeannot, Thierry Durroux, Cherine Bechara, Sébastien Granier, Cédric Leyrat

Publikováno v: eLife, Vol 11 (2022)

Staphylococcus aureus (SA) leukocidin ED (LukED) belongs to a family of bicomponent pore forming toxins that play important roles in SA immune evasion and nutrient acquisition. LukED targets specific G protein-coupled chemokine receptors to lyse huma

Externí odkaz: https://doaj.org/article/6a2d413ff8244168837148838406e319

Molecular insights into mechanisms of GPCR hijacking by Staphylococcus aureus

Autor: Thierry Durroux, Claire M. Grison, Cedric Leyrat, Remy Sounier, Sébastien Granier, Joyce Heuninck, Paul Lambey, Simon Fontanel, Sylvain Jeannot, Cherine Bechara, Fanny Peysson, Elise Del Nero

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2021, 118 (42), pp.e2108856118. ⟨10.1073/pnas.2108856118⟩
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America, 2021, 118 (42), pp.e2108856118. ⟨10.1073/pnas.2108856118⟩

International audience; Atypical chemokine receptor 1 (ACKR1) is a G protein–coupled receptor (GPCR) targeted by Staphylococcus aureus bicomponent pore-forming leukotoxins to promote bacterial growth and immune evasion. Here, we have developed an i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f790b8e83aeb2b4cdfe6486b611b27fd
https://hal.archives-ouvertes.fr/hal-03394409