Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Paul L. Stanley"'
Autor:
Steven H. Spergel, Robert V. Moquin, Ding Ren Shen, Jagabundhu Das, Gary L. Schieven, Kamelia Behnia, James Lin, O. Kocy, Paul L. Stanley, Sydney Pitt, John Wityak, Ping Chen, Sara Thrall, David J. Shuster, Derek J. Norris, Suhong Pang, Edwin J. Iwanowicz, Steven B. Kanner, Henry F. De Fex, Joel C. Barrish, Henry H. Gu, Kim W. McIntyre, Mark R. Witmer, Saeho Chong, Arthur M. Doweyko
Publikováno v:
Journal of Medicinal Chemistry. 47:4517-4529
A series of novel anilino 5-azaimidazoquinoxaline analogues possessing potent in vitro activity against p56Lck and T cell proliferation have been discovered. Subsequent SAR studies led to the identification of compound 4 (BMS-279700) as an orally act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09a41f06224f2dd8e51cbefbd63c03e7
https://doi.org/10.1021/jm030217e
https://doi.org/10.1021/jm030217e
Autor:
Wright John J, Brigitte Turmel, Serge Plamondon, Kenneth M. Tramposch, Paul L. Stanley, Alain Martel, Pierre Dextraze, Carol Bachand, Julie Alford, Carl Ouellet, Marcel Menard, Anne Marinier, Gordon Todderud, Jacques Banville, Jean-Paul Daris, Debbie Lee, Philippe Lapointe, Xina Nair
Publikováno v:
Bioorganic & Medicinal Chemistry. 9:1395-1427
A series of potent inhibitors of P-selectin as potential anti-inflammatory agents is reported. These compounds are derivatives of galactocerebrosides bearing a malonate side chain in positions 2 and 3 of the galactose moiety. Based on the binding mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3f94f1486084c27529de687fb62c136
https://doi.org/10.1016/s0968-0896(01)00015-3
https://doi.org/10.1016/s0968-0896(01)00015-3
Autor:
Stan V. D'Andrea, Kenneth M. Tramposch, James R. Burke, Joanne J. Bronson, Dane M. Springer, Kurt R. Gregor, Muzammil M. Mansuri, Paul L. Stanley, Bing Yu Luh
Publikováno v:
ChemInform. 28
Ten diacids were synthesized via a simple regio- and stereoselective aldol reaction. All of these compounds were good to excellent inhibitors of 14 kDa human platelet PLA2, and many of these derivatives displayed activity in a phorbol-ester induced m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b6a91886a2c5f76265dea8acd03e3ac
https://doi.org/10.1002/chin.199734107
https://doi.org/10.1002/chin.199734107
Autor:
Paul L. Stanley, Nicholas A. Meanwell, Steven M. Seiler, H. Belgin Guelgeze, Daniel G.M. Roberts, Pi Zulan, Gregory S. Bisacchi, Keith D. Combrink, Bradley C. Pearce
Publikováno v:
ChemInform. 30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7658933dc8b3bfe40d75a088542c2a9
https://doi.org/10.1002/chin.199913157
https://doi.org/10.1002/chin.199913157
Autor:
A.H. Lewin, Kenneth M. Tramposch, Paul L. Stanley, R C Franson, D O Nettleton, F I Carroll, Steiner Stephen A
Publikováno v:
Biochemical and Biophysical Research Communications. 189:272-279
Activation of a phospholipase A2 (PLA2) is a key step in the production of precursors for the biosynthesis of lipid mediators of inflammation. Inhibition of this enzyme could result in the suppression of three important classes of inflammatory lipids
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9cc3988a6aabd82b3a9fe473de1de57
https://doi.org/10.1016/0006-291x(92)91554-4
https://doi.org/10.1016/0006-291x(92)91554-4
Autor:
Anders Vahlquist, John J. Voorhees, E.M.G.J. de Jong, A. Buntinx, Douglas F. Gibbs, B. Friedman, Ethel Tur, Eva Stenström, James Varani, C.O. Bull, Paul L. Stanley, P.C.M. van de Kerkhof, Eva Andersson, Richard H. Guy, Thomas Ruzicka, J.C.M. Scholte, Steiner Stephen A, Hans Törmä, Marie L. Landry, Elka Touitou, Mary Havens, Kenneth M. Tramposch, James A. Mezick, Robert J. Capetola, Gerard J. Gendimenico, M. Ashraf, Pauline M. Schwartz, R. Panchagnula, Petr Arenberger, I.M.M.J. van Vlijmen, Howard I. Maibach, Lajos Kemény, Biren Shah, W. Tanaka, K. Stemmer, W.A. Ritschel, L.M. Milstone, H. Reuveni, Francesca Levi-Schaffer
Publikováno v:
Skin Pharmacology and Physiology. 4:I-VI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::684cf4ae33dd3c0e3160f012aa6d9d2a
https://doi.org/10.1159/000210954
https://doi.org/10.1159/000210954
Publikováno v:
Skin Pharmacology and Physiology. 4:262-271
It is well known that applications of a single dose of 12-O-tetradecanoylphorbol-13-acetate (TPA) to mouse ears induces an acute inflammatory reaction consisting of erythema, edema and polymorphonuclear leukocyte (PMN) infiltration. We report here th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b45b302db65385915d4f1a3641463a02
https://doi.org/10.1159/000210960
https://doi.org/10.1159/000210960
Autor:
Paul L. Stanley, Kenneth M. Tramposch, Fred Christopher Zusi, Steiner Stephen A, J. W. Quigley, Suresh A. Marathe, Xina Nair
Publikováno v:
Agents and Actions. 30:443-450
Drugs which block the biosynthesis of leukotrienes and prostaglandins may have potential in the treatment of psoriasis and other skin diseases. The biochemical and anti-inflammatory activity of 9-phenylnonanohydroxamic acid (BMY 30094) is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11ac69305a524ed65410e9717636b898
https://doi.org/10.1007/bf01966310
https://doi.org/10.1007/bf01966310
Autor:
Daniel G.M. Roberts, Nicholas A. Meanwell, Hatice Belgin Gulgeze, Gregory S. Bisacchi, Keith D. Combrink, P. Zulan, S. M. Seiler, Bradley C. Pearce, Paul L. Stanley
Publikováno v:
Journal of medicinal chemistry. 41(24)
A library of compounds were prepared by reacting 2-(bromomethyl)-1, 2-benzisothiazol-3(2H)-one 1,1-dioxide (5) with commercially available carboxylic acids in the presence of potassium carbonate or a tertiary amine base. From this library, (1,1-dioxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::243fe99f1f5bc8e7ae453df689d56b96
https://pubmed.ncbi.nlm.nih.gov/9822554
https://pubmed.ncbi.nlm.nih.gov/9822554
Publikováno v:
Agents and actions. 37(3-4)
We have previously shown that multiple topical applications, over 11 days, of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) induces a persistent inflammatory reaction characterized by edema, cell infiltration and epidermal hyperplasia.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d43f57e79d7ff4af672c040a599f00d4
https://pubmed.ncbi.nlm.nih.gov/1338267
https://pubmed.ncbi.nlm.nih.gov/1338267