Selection in males purges the mutation load on female fitness

Autor: Karl Grieshop, Paul L. Maurizio, Göran Arnqvist, David Berger

Publikováno v: Evolution Letters, Vol 5, Iss 4, Pp 328-343 (2021)

Abstract Theory predicts that the ability of selection and recombination to purge mutation load is enhanced if selection against deleterious genetic variants operates more strongly in males than females. However, direct empirical support for this ten

Externí odkaz: https://doaj.org/article/e0f6374f19b840e1b0a82ce8ce8bdd6b

A Diallel of the Mouse Collaborative Cross Founders Reveals Strong Strain-Specific Maternal Effects on Litter Size

Autor: John R. Shorter, Paul L. Maurizio, Timothy A. Bell, Ginger D. Shaw, Darla R. Miller, Terry J. Gooch, Jason S. Spence, Leonard McMillan, William Valdar, Fernando Pardo-Manuel de Villena

Publikováno v: G3: Genes, Genomes, Genetics, Vol 9, Iss 5, Pp 1613-1622 (2019)

Reproductive success in the eight founder strains of the Collaborative Cross (CC) was measured using a diallel-mating scheme. Over a 48-month period we generated 4,448 litters, and provided 24,782 weaned pups for use in 16 different published experim

Externí odkaz: https://doaj.org/article/d884049865cd449cbbaf7eb98722d981

Bayesian Diallel Analysis Reveals Mx1-Dependent and Mx1-Independent Effects on Response to Influenza A Virus in Mice

Autor: Paul L. Maurizio, Martin T. Ferris, Gregory R. Keele, Darla R. Miller, Ginger D. Shaw, Alan C. Whitmore, Ande West, Clayton R. Morrison, Kelsey E. Noll, Kenneth S. Plante, Adam S. Cockrell, David W. Threadgill, Fernando Pardo-Manuel de Villena, Ralph S. Baric, Mark T. Heise, William Valdar

Publikováno v: G3: Genes, Genomes, Genetics, Vol 8, Iss 2, Pp 427-445 (2018)

Influenza A virus (IAV) is a respiratory pathogen that causes substantial morbidity and mortality during both seasonal and pandemic outbreaks. Infection outcomes in unexposed populations are affected by host genetics, but the host genetic architectur

Externí odkaz: https://doaj.org/article/36f7b99e3cf2473e986a19729c5d2d05

Genetic regulation of homeostatic immune architecture in the lungs of Collaborative Cross mice

Autor: Ginger D. Shaw, Mark T. Heise, Martin T. Ferris, Alan C. Whitmore, Kenneth S. Plante, Brea K. Hampton, Ande West, Clayton R. Morrison, Ralph S. Baric, Colton L. Linnertz, Paul L. Maurizio, Darla R. Miller, Kara Jensen, Pardo-Manuel de Villena F, Kelsey E. Noll

SummaryVariation in immune homeostasis, immune system stability, in organ systems such as the lungs is likely to shape the host response to infection at these exposed tissues. We evaluated immune homeostasis in immune cell populations in the lungs of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::552359810ed94dce640bdc1e7c4f8156
https://doi.org/10.1101/2021.04.09.439180

Social history and exposure to pathogen signals modulate social status effects on gene regulation in rhesus macaques

Autor: Noah D. Simons, Jenny Tung, Mark E. Wilson, Paul L. Maurizio, Tawni Voyles, Joaquín Sanz, Luis B. Barreiro, Jordan N. Kohn, Vasiliki Michopoulos, Noah Snyder-Mackler

Publikováno v: Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname
Zaguán: Repositorio Digital de la Universidad de Zaragoza
Universidad de Zaragoza
Proc Natl Acad Sci U S A

Social experiences are an important predictor of disease susceptibility and survival in humans and other social mammals. Chronic social stress is thought to generate a pro-inflammatory state characterized by elevated antibacterial defenses and reduce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a8bf7499578f87df2a45cc75abe1c35
http://zaguan.unizar.es/record/96215