Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Paul L. Domanico"'
Autor:
Brady Sillman, Tai-Yuen Yue, Howard E. Gendelman, Nagsen Gautam, Melinda Wojtkiewicz, R. Lee Mosley, Adam M. Szlachetka, Bhagya Laxmi Dyavar Shetty, Sruthi Sravanam, Howard S. Fox, Jane L. Meza, Yazen Alnouti, James R. Hilaire, Aditya N. Bade, Tanmay A. Kulkarni, Paul L. Domanico, Benson J Edagwa, Brenda Morsey, Benjamin G. Lamberty, Gary Moore, JoEllyn M McMillan
Publikováno v:
Nature materials. 19(8)
Long-acting cabotegravir (CAB) extends antiretroviral drug administration from daily to monthly. However, dosing volumes, injection site reactions and health-care oversight are obstacles towards a broad usage. The creation of poloxamer-coated hydroph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edce3d8d71ee6472b6755874ca83dc4b
https://pubmed.ncbi.nlm.nih.gov/32704135
https://pubmed.ncbi.nlm.nih.gov/32704135
Autor:
Paul L. Domanico, Polly Clayden, Marco Vitoria, Andrew Hill, Francois Venter, Charles Flexner, Nathan Ford, Meg Doherty, David Ripin
Publikováno v:
AIDS (London, England). 32(12)
There are currently approximately 16 million people taking NNRTI-based first-line treatment in low-income and middle-income countries. Most of these patients are using the combination of tenofovir (TDF), lamivudine (3TC) and efavirenz (EFV). The inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ecb382cfa5113b1252c9033bef20af1
https://pubmed.ncbi.nlm.nih.gov/29746295
https://pubmed.ncbi.nlm.nih.gov/29746295
Autor:
Steve P. Rannard, Andrew Owen, Marco Siccardi, Steve Wring, Rajith K. R. Rajoli, Darren M. Moss, Melynda E. Watkins, Ryan Randolph, Seonghee Park, Paul L. Domanico, James J. Hobson
Publikováno v:
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Tenofovir disoproxil fumarate (TDF), a prodrug of tenofovir, has oral bioavailability (25%) limited by intestinal transport (P-glycoprotein), and intestinal degradation (carboxylesterase). However, the influence of luminal pancreatic enzymes is not f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::960d86ad95272ee9e418e4f9666e4b5b
Autor:
David L. Saussy, J. Alan Menius, Tony D. Choi, Michael W. Lutz, Aaron S. Goetz, Paul L. Domanico, Rebecca Gooding Laskody
Publikováno v:
Drug Discovery Today. 1:277-286
Novel methods in molecular biology and advanced technologies have given pharmaceutical research laboratories the capability to test combinatorial libraries rapidly against large numbers of potential targets. Methods to identify optimal assay conditio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::595cd01979be6f610071f9a3331205e4
https://doi.org/10.1016/1359-6446(96)10025-8
https://doi.org/10.1016/1359-6446(96)10025-8
Autor:
Jeffrey A. Stafford, Marcus F. Brackeen, Paul L. Feldman, James Marvin Veal, Margrith W. Verghese, Frank J. Schoenen, David J. Cowan, A. B. Strickland, D. Rose, Paul L. Domanico
Publikováno v:
Journal of Medicinal Chemistry. 38:4848-4854
The synthesis and biological evaluation of cAMP-specific phosphodiesterase (PDE IV) inhibitors is described. The PDE IV inhibitor 4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one (Ro 20-1724, 2) was used as a template from which to design a set of rigi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c82bb4872267d79a820318f3a041862e
https://doi.org/10.1021/jm00024a012
https://doi.org/10.1021/jm00024a012
Autor:
Jeffrey A. Stafford, Alan B Strickland, D. Rose, Paul L. Domanico, Michael A. Leesnitzer, David J. Cowan, Rayomand J. Unwalla, Stephen A. Stimpson, Paul L. Feldman, Nicole L. Valvano, E Sloan Brawley, Margrith W. Verghese
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:1977-1982
Structure-activity relationships within a series of 1,3,4-trisubstituted pyrrolidines, novel and selective inhibitors of cAMP-specific phosphodiesterase (PDE IV), are discussed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::893869299605435f076797071dd38d5a
https://doi.org/10.1016/0960-894x(95)00336-r
https://doi.org/10.1016/0960-894x(95)00336-r
Autor:
Paul L. Domanico
Publikováno v:
Chemometrics and Intelligent Laboratory Systems. 26:115-121
Drug discovery involves identifying, characterizing, and validating the target, and designing potent and specific chemical leads. Every aspect of this process is undergoing a technical and conceptual revolution. Medicinal chemists are synthesizing co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1205c2b724b55ab6462e2fcc38d0f38c
https://doi.org/10.1016/0169-7439(94)90053-1
https://doi.org/10.1016/0169-7439(94)90053-1
Autor:
Jeffrey A. Stafford, Rayomand J. Unwalla, Frank J. Schoenen, Paul L. Feldman, Brian Edward Marron, Paul L. Domanico, Nicole L. Valvano, E Sloan Brawley, D. Rose, Michael A. Leesnitzer, Robert W. Dougherty
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:1855-1860
Structure-activity relationships involving the aromatic ring of the selective PDE IV inhibitor, rolipram (1), are discussed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::434517a9cfbdef484098489732be5545
https://doi.org/10.1016/s0960-894x(01)80384-x
https://doi.org/10.1016/s0960-894x(01)80384-x
Autor:
Margrith W. Verghese, Jeffrey A. Stafford, James Marvin Veal, David J. Cowan, Paul L. Feldman, A. B. Strickland, Frank J. Schoenen, Marcus F. Brackeen, Paul L. Domanico, D. Rose
Publikováno v:
ChemInform. 27
The synthesis and biological evaluation of cAMP-specific phosphodiesterase (PDE IV) inhibitors is described. The PDE IV inhibitor 4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one (Ro 20-1724, 2) was used as a template from which to design a set of rigi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::500bd9f85dfcde9fef2d605600c4a64a
https://doi.org/10.1002/chin.199614135
https://doi.org/10.1002/chin.199614135
Autor:
Jeffrey M. Besterman, Paul L. Domanico
Publikováno v:
Biochemistry. 31:2046-2056
The association and metabolism of exogenously-derived lysophosphatidylcholine (lysoPC) with cultured mammalian cells from a variety of sources was studied, and a mechanism was defined by computer modeling for Vero cells. Cell monolayers were incubate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0d4c62848d9b356e406f363a2940f6d
https://doi.org/10.1021/bi00122a022
https://doi.org/10.1021/bi00122a022