Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Paul L. Boyer"'
Autor:
Jerry Joe E. K. Harrison, Steve Tuske, Kalyan Das, Francesc X. Ruiz, Joseph D. Bauman, Paul L. Boyer, Jeffrey J. DeStefano, Stephen H. Hughes, Eddy Arnold
Publikováno v:
Viruses, Vol 13, Iss 8, p 1495 (2021)
In most cases, proteolytic processing of the retroviral Pol portion of the Gag-Pol polyprotein precursor produces protease (PR), reverse transcriptase (RT), and integrase (IN). However, foamy viruses (FVs) express Pol separately from Gag and, when Po
Externí odkaz:
https://doaj.org/article/d2a2429c574c4515b047df0567c30b54
Autor:
Andrea L. Ferris, Robin Dewar, Frank Maldarelli, JoAnn M. Mican, Margaret R Caplan, Paul L. Boyer, Patrick K. Clark, Adam Johnson, Michael C. Sneller, Catherine Rehm, Stephen H. Hughes
Publikováno v:
Antimicrob Agents Chemother
Resistance to anti-Human Immunodeficiency Virus (HIV) drugs has been a problem from the beginning of antiviral drug treatments. The recent expansion of combination antiretroviral therapy worldwide has led to an increase in resistance to antiretrovira
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c80b03999969d8d74917a922a177113e
https://pubmed.ncbi.nlm.nih.gov/34723625
https://pubmed.ncbi.nlm.nih.gov/34723625
Publikováno v:
PLoS Pathogens, Vol 2, Iss 2, p e10 (2006)
The human immunodeficiency virus type 1 (HIV-1) develops resistance to all available drugs, including the nucleoside analog reverse transcriptase inhibitors (NRTIs) such as AZT. ATP-mediated excision underlies the most common form of HIV-1 resistance
Externí odkaz:
https://doaj.org/article/470470b2951c498e8ffe1006c340461b
Autor:
Paul L. Boyer, Linda L. Dunn, Steven J. Smith, Richa Dwivedi, Douglas K. Fischer, Pat Clark, Stephen H. Hughes, Chris Kline, Kevin Melody, Zandrea Ambrose
Publikováno v:
Journal of Virology
Although antiretroviral therapy (ART) is highly successful, drug-resistant variants can arise that blunt the efficacy of ART. New inhibitors that are broadly effective against known drug-resistant variants are needed, although such compounds might se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb70e9170f223406aa0f293dbe410c87
http://europepmc.org/articles/PMC6532099
http://europepmc.org/articles/PMC6532099
Publikováno v:
Journal of Virology. 86:5885-5894
As anti-HIV therapy becomes more widely available in developing nations, it is clear that drug resistance will continue to be a major problem. The related viruses HIV-1 and HIV-2 share many of the same resistance pathways to nucleoside reverse transc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c15917511d45ab81cf94b190e762098b
https://doi.org/10.1128/jvi.06597-11
https://doi.org/10.1128/jvi.06597-11
Autor:
Eun Gyung Lee, Maxine L. Linial, Jacqueline Roy, Patrick K. Clark, Stephen H. Hughes, Paul L. Boyer, Dana L. Jackson
Publikováno v:
Journal of Virology. 85:1655-1661
Unlike orthoretroviruses, foamy retroviruses (FV) synthesize Pol independently of Gag. The FV Pol precursor is cleaved only once between reverse transcriptase (RT) and integrase (IN) by the protease (PR), resulting in a PR-RT and an IN protein. Only
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f06c5b86ff97f212f6ea8d58ffd6ba1
https://doi.org/10.1128/jvi.01873-09
https://doi.org/10.1128/jvi.01873-09
Autor:
Rajiv P. Bandwar, Paul L. Boyer, Kirsten L. White, Joy Y. Feng, Eddy Arnold, Arthur D. Clark, Xiongying Tu, Kalyan Das, Xiaorong Hou, Michael D. Miller, Stefan G. Sarafianos, Roger A. Jones, Steven Tuske, Stephen H. Hughes, Barbara L. Gaffney
Publikováno v:
The Journal of Biological Chemistry
K65R is a primary reverse transcriptase (RT) mutation selected in human immunodeficiency virus type 1-infected patients taking antiretroviral regimens containing tenofovir disoproxil fumarate or other nucleoside analog RT drugs. We determined the cry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1c3d60a055f6e404ae300581c978eda
https://doi.org/10.1074/jbc.m109.022525
https://doi.org/10.1074/jbc.m109.022525
Autor:
Vinay K. Pathak, Paul L. Boyer, Abhay Jere, Krista A. Delviks-Frankenberry, Stephen H. Hughes, Galina N. Nikolenko, John M. Coffin
Publikováno v:
Proceedings of the National Academy of Sciences. 105:10943-10948
We previously proposed that mutations in the connection subdomain (cn) of HIV-1 reverse transcriptase increase AZT resistance by altering the balance between nucleotide excision and template RNA degradation. To test the predictions of this model, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c29cd3ae78c580e37bdc9c7e591765d1
https://doi.org/10.1073/pnas.0804660105
https://doi.org/10.1073/pnas.0804660105
Autor:
Daniel M. Himmel, William C. Ho, Deena A. Oren, Arthur D. Clark, Stephen H. Hughes, Eddy Arnold, Kalyan Das, Paul L. Boyer, Joseph D. Bauman, Aaron J. Shatkin, Mukta Baweja
Publikováno v:
Nucleic Acids Research
HIV-1 reverse transcriptase (RT) is a primary target for anti-AIDS drugs. Structures of HIV-1 RT, usually determined at approximately 2.5-3.0 A resolution, are important for understanding enzyme function and mechanisms of drug resistance in addition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bd6af6db5a53c335c549b83d22f4a3c
https://doi.org/10.1093/nar/gkn464
https://doi.org/10.1093/nar/gkn464
Publikováno v:
Virology. 367:253-264
We compared the in vitro fidelity of wild-type human immunodeficiency virus type-1 (HIV-1) reverse transcriptase (RT) and the prototype foamy virus (PFV) RT. Both enzymes had similar error rates for single nucleotide substitutions; however, PFV RT di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36788665b8cf70fd440ce2d61e8feb3a
https://doi.org/10.1016/j.virol.2007.05.034
https://doi.org/10.1016/j.virol.2007.05.034