Zobrazeno 1 - 10
of 164
pro vyhledávání: '"Paul L. Bollyky"'
Autor:
Silvia Würstle, Alina Lee, Kaitlyn E. Kortright, Franziska Winzig, William An, Gail L. Stanley, Govindarajan Rajagopalan, Zach Harris, Ying Sun, Buqu Hu, Michael Blazanin, Maryam Hajfathalian, Paul L. Bollyky, Paul E. Turner, Jonathan L. Koff, Benjamin K. Chan
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Bacteriophage therapy is one potential strategy to treat antimicrobial resistant or persistent bacterial infections, and the year 2021 marked the centennial of Felix d’Hérelle’s first publication on the clinical applications of phages.
Externí odkaz:
https://doaj.org/article/41cdfd5460a14d8d9cd220874c8a6c29
Autor:
Hunter A. Martinez, Ievgen Koliesnik, Gernot Kaber, Jacqueline K. Reid, Nadine Nagy, Graham Barlow, Ben A. Falk, Carlos O. Medina, Aviv Hargil, Svenja Zihsler, Israel Vlodavsky, Jin-Ping Li, Magdiel Pérez-Cruz, Sai-Wen Tang, Everett H. Meyer, Lucile E. Wrenshall, James D. Lord, K. Christopher Garcia, Theo D. Palmer, Lawrence Steinman, Gerald T. Nepom, Thomas N. Wight, Paul L. Bollyky, Hedwich F. Kuipers
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Although FOXP3+ regulatory T cells (Treg) depend on IL-2 produced by other cells for their survival and function, the levels of IL-2 in inflamed tissue are low, making it unclear how Treg access this critical resource. Here, we show that Tre
Externí odkaz:
https://doaj.org/article/378775d4b0fd41108905367cda2de0de
Autor:
Nadine Nagy, Kathryn S. Czepiel, Gernot Kaber, Darko Stefanovski, Aviv Hargil, Nina Pennetzdorfer, Robert Targ, Saranya C. Reghupaty, Thomas N. Wight, Robert B. Vernon, Rebecca L. Hull-Meichle, Payton Marshall, Carlos O. Medina, Hunter Martinez, Anissa Kalinowski, Rudolph D. Paladini, Stavros Garantziotis, Joshua W. Knowles, Paul L. Bollyky
Publikováno v:
Cells, Vol 13, Iss 20, p 1727 (2024)
Given that the extracellular matrix polymer hyaluronan (HA) has been implicated in longevity, we asked whether 4-methylumbelliferone (4-MU), an inhibitor of HA synthesis, impacts lifespan in mice. We designed a prospective study of long-term administ
Externí odkaz:
https://doaj.org/article/da7d8866843c4dd994d1c93481a81662
Autor:
Maryam Hajfathalian, Christiaan R. de Vries, Jessica C. Hsu, Ahmad Amirshaghaghi, Yuxi C. Dong, Zhi Ren, Yuan Liu, Yue Huang, Yong Li, Simon A.B. Knight, Pallavi Jonnalagadda, Aimen Zlitni, Elizabeth A. Grice, Paul L. Bollyky, Hyun Koo, David P. Cormode
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 21 (2023)
Biofilms are structured communities of microbial cells embedded in a self-produced matrix of extracellular polymeric substances. Biofilms are associated with many health issues in humans, including chronic wound infections and tooth decay. Current an
Externí odkaz:
https://doaj.org/article/b99ed845707e4ebba806d4d215686db5
Autor:
Nina Pennetzdorfer, Medeea C. Popescu, Naomi L. Haddock, Fannie Dupuy, Gernot Kaber, Aviv Hargil, Patrik K. Johansson, Annika Enejder, Paul L. Bollyky
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
Pseudomonas aeruginosa is a major human pathogen, particularly effective at colonizing the airways of patients with cystic fibrosis. Bacteriophages are highly abundant at infection sites, but their impact on mammalian immunity remains unclear. We pre
Externí odkaz:
https://doaj.org/article/6c40b20b46ef483f99cd6caad4fd8eca
Autor:
Anping Xia, Anthony Thai, Zhixin Cao, Xiaohua Chen, Jing Chen, Brian Bacacao, Laurent A. Bekale, Viktoria Schiel, Paul L. Bollyky, Peter L. Santa Maria
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-15 (2022)
Abstract Background Chronic suppurative otitis media (CSOM) is the most common cause of permanent hearing loss in children in the developing world. A large component of the permanent hearing loss is sensory in nature and our understanding of the mech
Externí odkaz:
https://doaj.org/article/958afb0cf6b0467980759237b07e4366
Autor:
Medeea C. Popescu, Naomi L. Haddock, Elizabeth B. Burgener, Laura S. Rojas-Hernandez, Gernot Kaber, Aviv Hargil, Paul L. Bollyky, Carlos E. Milla
Publikováno v:
Viruses, Vol 16, Iss 1, p 165 (2024)
Background: The inovirus Pf4 is a lysogenic bacteriophage of Pseudomonas aeruginosa (Pa). People with Cystic Fibrosis (pwCF) experience chronic airway infection with Pa and a significant proportion have high numbers of Pf4 in their airway secretions.
Externí odkaz:
https://doaj.org/article/9fe7d46604d04d53acc440207a002477
Autor:
Michael J. Kratochvil, Gernot Kaber, Sally Demirdjian, Pamela C. Cai, Elizabeth B. Burgener, Nadine Nagy, Graham L. Barlow, Medeea Popescu, Mark R. Nicolls, Michael G. Ozawa, Donald P. Regula, Ana E. Pacheco-Navarro, Samuel Yang, Vinicio A. de Jesus Perez, Harry Karmouty-Quintana, Andrew M. Peters, Bihong Zhao, Maximilian L. Buja, Pamela Y. Johnson, Robert B. Vernon, Thomas N. Wight, Stanford COVID-19 Biobank Study Group, Carlos E. Milla, Angela J. Rogers, Andrew J. Spakowitz, Sarah C. Heilshorn, Paul L. Bollyky
Publikováno v:
JCI Insight, Vol 7, Iss 12 (2022)
Thick, viscous respiratory secretions are a major pathogenic feature of COVID-19, but the composition and physical properties of these secretions are poorly understood. We characterized the composition and rheological properties (i.e., resistance to
Externí odkaz:
https://doaj.org/article/5333021197714d0f86602625ced4f91f
Autor:
Emily H. Steen, Walker D. Short, Hui Li, Umang M. Parikh, Alexander Blum, Natalie Templeman, Nadine Nagy, Paul L. Bollyky, Sundeep G. Keswani, Swathi Balaji
Publikováno v:
Drug Delivery, Vol 28, Iss 1, Pp 422-432 (2021)
Hyaluronan (HA) is abundant in the skin; while HA can be synthesized by the synthases (HAS1-3), HAS2 is the leading contributor. Dysregulation and accumulation of HA is implicated in the pathogenesis of diseases such as keloid scarring, lymphedema an
Externí odkaz:
https://doaj.org/article/2caa614288f94200a74e5242dcbd3d30
Autor:
Joelle I. Rosser, Nadine Nagy, Riya Goel, Gernot Kaber, Sally Demirdjian, Jamie Saxena, Jennifer B. Bollyky, Adam R. Frymoyer, Ana E. Pacheco-Navarro, Elizabeth B. Burgener, Jayakumar Rajadas, Zhe Wang, Olga Arbach, Colleen E. Dunn, Anissa Kalinowski, Carlos E. Milla, Paul L. Bollyky
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 9 (2022)
BACKGROUND Hyaluronan (HA), an extracellular matrix glycosaminoglycan, has been implicated in the pathophysiology of COVID-19 infection, pulmonary hypertension, pulmonary fibrosis, and other diseases, but is not targeted by any approved drugs. We ask
Externí odkaz:
https://doaj.org/article/f748f673d08f429f9f1becca4580831e