Zobrazeno 1 - 10
of 137
pro vyhledávání: '"Paul L Hermonat"'
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e104596 (2014)
Adeno-associated virus (AAV) (type 2) is a popular human gene therapy vector with a long active transgene expression period and no reported vector-induced adverse reactions. Yet the basic molecular biology of this virus has not been fully addressed.
Externí odkaz:
https://doaj.org/article/9f834d1bc0a444058320b9c9bf91aff2
Autor:
Hongqing Zhu, Maohua Cao, Leonardo Mirandola, Jose A Figueroa, Everardo Cobos, Maurizio Chiriva-Internati, Paul L Hermonat
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94665 (2014)
The development of gene therapy vectors for treating diseases of the cardiovascular system continues at a steady pace. Moreover, in the field of gene therapy the utility of "disease-specific promoters" has strong appeal. Many therapeutic genes, inclu
Externí odkaz:
https://doaj.org/article/06028fdcc81a4e369620e54f40b928f0
Publikováno v:
International Journal of Vascular Medicine, Vol 2012 (2012)
Both IL-10 and STAT3 are in the same signal transduction pathway, with IL-10-bound IL10 receptor (R) acting through STAT3 for anti-inflammatory effect. To investigate possible therapeutic synergism, we delivered both full-length wild-type human (h) S
Externí odkaz:
https://doaj.org/article/7e31e0529abe471e9eb31f846211d811
Autor:
Kayley Trotter, Lauren Littlefield, Venu Madhav Konala, Fabio Grizzi, Paul L. Hermonat, Adair Reidy, Breeanna Musgrove, Leonardo Mirandola, Rakhshanda Layeequr Rahman, Luke N. D'Cunha, Maurizio Chiriva-Internati, Saba Radhi, Jose A. Figueroa, Alejandro Figueroa, Everardo Cobos, Nicholas D'Cunha, Natallia Suvorava, Marjorie R. Jenkins, Amardeep Aulakh
Publikováno v:
International Reviews of Immunology. 34:154-187
Cancer immunotherapy comprises different therapeutic strategies that exploit the use of distinct components of the immune system, with the common goal of specifically targeting and eradicating neoplastic cells. These varied approaches include the use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0ef994240da06a2545d565024bd5e96
https://doi.org/10.3109/08830185.2015.1018419
https://doi.org/10.3109/08830185.2015.1018419
Publikováno v:
OncoImmunology. 1:847-855
Adoptive transfer of antigen-specific cytotoxic T lymphocytes (CTL) holds significant promise in treating cancer and Th1 response cytokines are critical for their stimulation. Recently we reported that interleukin 7-(IL-7) and interferongamma-(IFNγ)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc5e38241aca72f9afda26dd8b066c3f
https://doi.org/10.4161/onci.20504
https://doi.org/10.4161/onci.20504
Publikováno v:
Gene therapy
Adeno-associated virus type 2 (AAV) is a popular vector for human gene therapy, because of its safety record and ability to express genes long term. Yet large-scale recombinant (r) AAV production remains problematic because of low particle yield. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce133c2d5e60fc8a4e90012058acc836
http://europepmc.org/articles/PMC3220924
http://europepmc.org/articles/PMC3220924
Publikováno v:
Cardiovascular Drugs and Therapy. 25:393-400
The importance of the lectin-like oxidized LDL receptor (LOX-1) gene in cardiovascular and other diseases is slowly being revealed. LOX-1 gene expression appears to be a "canary in a coal mine" for atherogenesis, being strongly up-regulated early on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae5a509f1b13cbb6490e96f8cdb39003
https://doi.org/10.1007/s10557-011-6322-8
https://doi.org/10.1007/s10557-011-6322-8
Publikováno v:
Atherosclerosis. 213:59-66
Atherosclerosis is an inflammatory disorder of arteries. Signal transducer and activator of transcription-3 (STAT3), an important signal transduction molecule, responds to a number of interleukins (IL) including IL-10, and has a significant immunosup
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82f9a35cc1fd45569b020f7539101e4d
https://doi.org/10.1016/j.atherosclerosis.2010.07.029
https://doi.org/10.1016/j.atherosclerosis.2010.07.029
Publikováno v:
Virology. 402:94-101
Human papillomavirus type 16 (HPV) E1 protein provides helper function for the adeno-associated virus type 2 (AAV) life cycle. E1 is the replication protein of HPV, analogous to AAV Rep78, but without the endonuclease/covalent attachment activity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3f57a27d2397125eae987fd5a794278
https://doi.org/10.1016/j.virol.2010.03.001
https://doi.org/10.1016/j.virol.2010.03.001
Autor:
Jawahar L. Mehta, Bum-Yong Kang, Junaid A. Khan, Paul L. Hermonat, Magomed Khaidakov, Wenze Wang
Publikováno v:
Biochemical and Biophysical Research Communications. 387:543-547
Statins, inhibitors of 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase, have been shown to induce both angiogenic and angiostatic responses. We attempted to resolve this controversy by studying the effects of two different statins, rosuvastatin and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c90399af082c4a98ed0b8ce1293067ac
https://doi.org/10.1016/j.bbrc.2009.07.057
https://doi.org/10.1016/j.bbrc.2009.07.057