Zobrazeno 1 - 10
of 211
pro vyhledávání: '"Paul L Fox"'
Autor:
Robert N Helsley, Venkateshwari Varadharajan, Amanda L Brown, Anthony D Gromovsky, Rebecca C Schugar, Iyappan Ramachandiran, Kevin Fung, Mohammad Nasser Kabbany, Rakhee Banerjee, Chase K Neumann, Chelsea Finney, Preeti Pathak, Danny Orabi, Lucas J Osborn, William Massey, Renliang Zhang, Anagha Kadam, Brian E Sansbury, Calvin Pan, Jessica Sacks, Richard G Lee, Rosanne M Crooke, Mark J Graham, Madeleine E Lemieux, Valentin Gogonea, John P Kirwan, Daniela S Allende, Mete Civelek, Paul L Fox, Lawrence L Rudel, Aldons J Lusis, Matthew Spite, J Mark Brown
Publikováno v:
eLife, Vol 8 (2019)
Recent studies have identified a genetic variant rs641738 near two genes encoding membrane bound O-acyltransferase domain-containing 7 (MBOAT7) and transmembrane channel-like 4 (TMC4) that associate with increased risk of non-alcoholic fatty liver di
Externí odkaz:
https://doaj.org/article/f9448bea0b9e426ea0147da3a9110b3e
Condensin II and GAIT complexes cooperate to restrict LINE-1 retrotransposition in epithelial cells.
Autor:
Jacqueline R Ward, Kommireddy Vasu, Emily Deutschman, Dalia Halawani, Peter A Larson, Dongmei Zhang, Belinda Willard, Paul L Fox, John V Moran, Michelle S Longworth
Publikováno v:
PLoS Genetics, Vol 13, Iss 10, p e1007051 (2017)
LINE-1 (L1) retrotransposons can mobilize (retrotranspose) within the human genome, and mutagenic de novo L1 insertions can lead to human diseases, including cancers. As a result, cells are actively engaged in preventing L1 retrotransposition. This w
Externí odkaz:
https://doaj.org/article/b6c172ada2f4465b888935d27b1d06d7
Autor:
Hao Zhou, Katarzyna Bulek, Xiao Li, Tomasz Herjan, Minjia Yu, Wen Qian, Han Wang, Gao Zhou, Xing Chen, Hui Yang, Lingzi Hong, Junjie Zhao, Luke Qin, Koichi Fukuda, Annette Flotho, Ji Gao, Ashok Dongre, Julie A Carman, Zizhen Kang, Bing Su, Timothy S Kern, Jonathan D Smith, Thomas A Hamilton, Frauke Melchior, Paul L Fox, Xiaoxia Li
Publikováno v:
eLife, Vol 6 (2017)
Expression of inflammatory genes is determined in part by post-transcriptional regulation of mRNA metabolism but how stimulus- and transcript-dependent nuclear export influence is poorly understood. Here, we report a novel pathway in which LPS/TLR4 e
Externí odkaz:
https://doaj.org/article/5b84f1b2b69f41da8fc9474e0ca9c10d
Autor:
Rashmi Bharti, Goutam Dey, Debjit Khan, Alex Myers, Olivia G. Huffman, Caner Saygin, Chad Braley, Elliott Richards, Naseer Sangwan, Belinda Willard, Justin D. Lathia, Paul L. Fox, Feng Lin, Babal Kant Jha, J. Mark Brown, Jennifer S. Yu, Mohammed Dwidar, Amy Joehlin-Price, Roberto Vargas, Chad M. Michener, Michelle S. Longworth, Ofer Reizes
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-23 (2024)
Abstract Background Platinum resistance is the primary cause of poor survival in ovarian cancer (OC) patients. Targeted therapies and biomarkers of chemoresistance are critical for the treatment of OC patients. Our previous studies identified cell su
Externí odkaz:
https://doaj.org/article/adfec356b7014a638df6edb322f5b4fb
Autor:
Debjit Khan, Iyappan Ramachandiran, Kommireddy Vasu, Arnab China, Krishnendu Khan, Fabio Cumbo, Dalia Halawani, Fulvia Terenzi, Isaac Zin, Briana Long, Gregory Costain, Susan Blaser, Amanda Carnevale, Valentin Gogonea, Ranjan Dutta, Daniel Blankenberg, Grace Yoon, Paul L. Fox
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-24 (2024)
Abstract Hypomyelinating leukodystrophy (HLD) is an autosomal recessive disorder characterized by defective central nervous system myelination. Exome sequencing of two siblings with severe cognitive and motor impairment and progressive hypomyelinatio
Externí odkaz:
https://doaj.org/article/3f6584a19f4b41cfbb1ed508918c473a
Publikováno v:
Biological Research, Vol 39, Iss 1, Pp 59-66 (2006)
Translational control is a common regulatory mechanism for the expression of iron-related proteins. For example, three enzymes involved in erythrocyte development are regulated by three different control mechanisms: globin synthesis is modulated by h
Externí odkaz:
https://doaj.org/article/9526e5493d8549d580c63ff8391a8c97
Autor:
Alka A Potdar, Joydeep Sarkar, Nupur K Das, Paroma Ghosh, Miklos Gratzl, Paul L Fox, Gerald M Saidel
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 7, p e1003701 (2014)
A major process of iron homeostasis in whole-body iron metabolism is the release of iron from the macrophages of the reticuloendothelial system. Macrophages recognize and phagocytose senescent or damaged erythrocytes. Then, they process the heme iron
Externí odkaz:
https://doaj.org/article/186cc27ae09e49d4a2d31164fdb932ff
Autor:
Partho Sarothi Ray, Paul L Fox
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e98493 (2014)
Repeated domains in proteins that have undergone duplication or loss, and sequence divergence, are especially informative about phylogenetic relationships. We have exploited divergent repeats of the highly structured, 50-amino acid WHEP domains that
Externí odkaz:
https://doaj.org/article/9afbe1016d424d5c887765b1186ea1fe
Autor:
Peng Yao, Alka A Potdar, Partho Sarothi Ray, Sandeepa M Eswarappa, Andrew C Flagg, Belinda Willard, Paul L Fox
Publikováno v:
PLoS Biology, Vol 11, Iss 8, p e1001635 (2013)
Cell regulatory circuits integrate diverse, and sometimes conflicting, environmental cues to generate appropriate, condition-dependent responses. Here, we elucidate the components and mechanisms driving a protein-directed RNA switch in the 3'UTR of v
Externí odkaz:
https://doaj.org/article/6184c638a0c14254a7434832fc301adc
Autor:
Kommireddy Vasu, Iyappan Ramachandiran, Aayushi Chechi, Krishnendu Khan, Debjit Khan, Randall Kaufman, Paul L. Fox
Publikováno v:
RNA Biology, Vol 20, Iss 1, Pp 737-749 (2023)
Adiponectin, an adipocyte-specific secretory protein encoded by the ADIPOQ gene has a causal role in insulin resistance. Anti-diabetic drugs increase plasma adiponectin by a poorly understood, post-transcriptional mechanism enhancing insulin sensitiv
Externí odkaz:
https://doaj.org/article/0efae32f955d47489424ea3f7b9f82be