Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Paul L Feldman"'
Autor:
Derek J Nunez, Mark A Bush, David A Collins, Susan L McMullen, Dawn Gillmor, Glen Apseloff, George Atiee, Leonor Corsino, Linda Morrow, Paul L Feldman
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e92494 (2014)
GPR119 receptor agonists improve glucose metabolism and alter gut hormone profiles in animal models and healthy subjects. We therefore investigated the pharmacology of GSK1292263 (GSK263), a selective GPR119 agonist, in two randomized, placebo-contro
Externí odkaz:
https://doaj.org/article/74b4a7893b1c4e2f9bf115e1a0fa43ef
Autor:
Doris Zane, Shane Roller, Josephine Shelton, Roshni Singh, Rachna Jain, Yan Wang, Bing Yang, Melanie Felx, Thomas Alessi, Paul L. Feldman
Publikováno v:
Microbiology Spectrum, Vol 9, Iss 1 (2021)
ABSTRACT The toxicity of tenofovir alafenamide (TAF) hemifumarate (HF) was evaluated when administered by continuous subcutaneous (s.c.) infusion via an external infusion pump for 28 days to rats and dogs. The toxicokinetics of TAF and two metabolite
Externí odkaz:
https://doaj.org/article/ac5032bd3bee415591a2bda456ba4cb2
Autor:
Zach R. Demkovich, Manjula Gunawardana, Ronald S. Veazey, Ariane van der Straten, Paul L. Feldman, John A. Moss, Ivana Massud, Alessandro Grattoni, Duy Khiet Ho, Frank DIana, Doris Zane, Mark Milad, Fernanda P. Pons-Faudoa, Marc M. Baum, Shane Roller, Thomas J. Hope, Joseph Romano, Charles Dobard, Selvi Srinivasan, J. Gerardo García-Lerma
Publikováno v:
AIDS Research and Human Retroviruses
The ability to successfully develop a safe and effective vaccine for the prevention of HIV infection has proven challenging. Consequently, alternative approaches to HIV infection prevention have been pursued, and there have been a number of successes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1960ae602db1d3b15e8c97bb2bac13c
https://doi.org/10.1089/aid.2021.0028
https://doi.org/10.1089/aid.2021.0028
Autor:
Paul L. Feldman
Publikováno v:
Anesthesiology. 132:1229-1234
Design, Synthesis, and Pharmacological Evaluation of Ultrashort- to Long-acting Opioid Analgetics. By Feldman PL, James MK, Brackeen MF, Bilotta JM, Schuster SV, Lahey AP, Lutz MW, Johnson MR, Leighton HJ. J Med Chem 1991; 34:2202-8. Copyright 1991 A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bd013c1a807fec5e6c3b8e4fa951bec
https://doi.org/10.1097/aln.0000000000003170
https://doi.org/10.1097/aln.0000000000003170
Publikováno v:
International journal of toxicology. 40(2)
There has been an increased interest in and activity for the use of peptide therapeutics to treat a variety of human diseases. The number of peptide drugs entering clinical development and the market has increased significantly over the past decade d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2be785cb891a4c70c39da9be855301d
https://pubmed.ncbi.nlm.nih.gov/33327828
https://pubmed.ncbi.nlm.nih.gov/33327828
Autor:
Mary K. Grizzle, Ved Srivastava, Rebecca J. Hodge, Mark A. Paulik, Andrew A. Young, Paul L. Feldman, Tom Tlusty, Shane Roller, Sharon Weng, Marci Copeland, William Blackwell, James M. Way, Doris Zane
Publikováno v:
Diabetes. 67
ICA6150349, a 38-amino acid analog of glucagon, is peptidase resistant and highly selective for the glucagon receptor. ICA6150349 continuously infused SC at 50 mcg/kg/d (ED50) in DIO LE rats reduced weight (21%), fat mass (37%), and food intake (17%)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5098fe4d71a1e3811239311092ffbb43
https://doi.org/10.2337/db18-1998-p
https://doi.org/10.2337/db18-1998-p
Autor:
Josephine Shelton, William Blackwell, Rebecca J. Hodge, Paul L. Feldman, Doris Zane, James M. Way, Roshni Singh, Ved Srivastava, Shane Roller, Mark A. Paulik, Thomas R. Alessi
Publikováno v:
Diabetes. 67
ICA6150349, a 38-amino-acid peptide, is a glucagon analog that is highly selective for the human glucagon receptor. In a 14-day toxicity study, rats and cynomolgus monkeys received ICA6150349 at doses of 0, 0.875, 8.75, 87.5 mcg/day and 0, 17.92, 179
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a8b76a7b392206799084f0d3850bf4e
https://doi.org/10.2337/db18-1997-p
https://doi.org/10.2337/db18-1997-p
Autor:
Eric E. Boros, Robert L. Dobbins, Maggie S. McIntyre, Ryan Klein, David J. Cowan, Xi Liang, Xiaozhou Yao, Andrew A. Young, Kristin M. Patterson, Paul L. Feldman, John Ray, Christine L. Merrill, Lindsey T. Harston, Jeff L. Ambroso, Jon L. Collins, Shane Roller, Michael J. Bishop, Judith S. Prescott, Christopher Joseph Aquino, Alan Cunningham, Don L. Anderson, Istvan Kaldor, Wu Yulin, Lihong Chen, Josephine Yuen
Publikováno v:
Journal of Medicinal Chemistry. 56:5094-5114
The apical sodium-dependent bile acid transporter (ASBT) transports bile salts from the lumen of the gastrointestinal (GI) tract to the liver via the portal vein. Multiple pharmaceutical companies have exploited the physiological link between ASBT an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9523f25c740c4bfebda108696b3a49b
https://doi.org/10.1021/jm400459m
https://doi.org/10.1021/jm400459m
Autor:
Paul D. Leeson, Martin K. Bayliss, Anthony J. Taylor, Paul L. Feldman, Palovich Michael R, James Butler, Darren V. S. Green
Publikováno v:
Drug discovery today. 21(10)
In an attempt to seek increased understanding of compound attributes that influence successful drug pipeline progression, GlaxoSmithKline's portfolio of oral candidates was compared with reference sets of marketed oral drugs. The approach differs fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83c1d62bb595607a1cbf3d1b389ccb95
https://pubmed.ncbi.nlm.nih.gov/27423371
https://pubmed.ncbi.nlm.nih.gov/27423371
Autor:
Gary Stuart Tilbrook, Gavin J. Kilpatrick, Barbara L. Waszczak, Margaret S McIntyre, Richard F. Cox, Holly A. Collins, Gwyer G Lovell, Gregory J Pacofsky, Robert P. Wiard, Jeffrey A. Stafford, Paul L. Feldman
Publikováno v:
Anesthesiology. 107:60-66
Background: A new benzodiazepine derivative, CNS 7056, has been developed to permit a superior sedative profile to current agents, i.e., more predictable fast onset, short duration of sedative action, and rapid recovery profile. This goal has been ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14c2bac3526d1c834ff29602b6309efa
https://doi.org/10.1097/01.anes.0000267503.85085.c0
https://doi.org/10.1097/01.anes.0000267503.85085.c0