Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Paul L Chariou"'
Autor:
Paul L Chariou, Christine M Minnar, Mayank Tandon, Mary R Guest, Raj Chari, Jeffrey Schlom, Sofia R Gameiro
Publikováno v:
PLoS ONE, Vol 19, Iss 3, p e0287733 (2024)
Immune checkpoint blockade (ICB) targeting the programmed cell death protein 1 (PD-1) and its ligand 1 (PD-L1) fails to provide clinical benefit for most cancer patients due to primary or acquired resistance. Drivers of ICB resistance include tumor a
Externí odkaz:
https://doaj.org/article/b16a5fa1ff184a238cef603abf88e301
Autor:
Jeffrey Schlom, Claudia Palena, Sofia R Gameiro, Lucas A Horn, Kristin C Hicks, Christine M Minnar, Paul L Chariou
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 6 (2022)
Externí odkaz:
https://doaj.org/article/c40ceb0f60fb49e39cb33a9a377eeb7f
Autor:
S. Elizabeth Franks, Ginette S. Santiago-Sanchez, Kellsye P. Fabian, Kristen Solocinski, Paul L. Chariou, Duane H. Hamilton, Joshua T. Kowalczyk, Michelle R. Padget, Sofia R. Gameiro, Jeffrey Schlom, James W. Hodge
Publikováno v:
Cancer Immunology, Immunotherapy.
There is strong evidence that chemotherapy can induce tumor necrosis which can be exploited for the targeted delivery of immuno-oncology agents into the tumor microenvironment (TME). We hypothesized that docetaxel, a chemotherapeutic agent that induc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d29858f0b78507088b0f683a8c29d5cf
https://doi.org/10.1007/s00262-023-03459-7
https://doi.org/10.1007/s00262-023-03459-7
Autor:
Yifeng Ma, Erin N. Rosskopf, Jason C. Hong, Paul L. Chariou, Michael Hensley, Nicole F. Steinmetz, Raghavan Charudattan
Publikováno v:
ACS Agricultural Science & Technology. 1:124-130
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4dac506e3cad52d7cf7b2153e5462b2
https://doi.org/10.1021/acsagscitech.1c00083
https://doi.org/10.1021/acsagscitech.1c00083
Publikováno v:
Materials Advances
Cowpea mosaic virus (CPMV) is currently in the development pipeline for multiple biomedical applications, including cancer immunotherapy. In particular the application of CPMV as in situ vaccine has shown promise; here the plant viral nanoparticle is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4831ea336205f2e83f2a5310e0edbf91
https://doi.org/10.1039/d0ma00752h
https://doi.org/10.1039/d0ma00752h
Autor:
He Hu, Sourabh Shukla, Soo-Khim Chan, Veronique Beiss, Hui Cai, Paul L. Chariou, Christine Boone, Nicole F. Steinmetz
Publikováno v:
Annu Rev Virol
Viral nanotechnology exploits the prefabricated nanostructures of viruses, which are already abundant in nature. With well-defined molecular architectures, viral nanocarriers offer unprecedented opportunities for precise structural and functional man
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3459894236ca6cd1f7af52a14cbe2255
https://doi.org/10.1146/annurev-virology-010720-052252
https://doi.org/10.1146/annurev-virology-010720-052252
Autor:
Nicole F. Steinmetz, Veronique Beiss, Paul L. Chariou, Ricardo Rueda, Joseph Wang, Miguel Angel Lopez-Ramirez, Daniel Kupor, Chao Wang, Christine Boone, Sourabh Shukla
Publikováno v:
ACS Applied Nano Materials. 3:8037-8051
The solid tumor microenvironment (TME) poses a significant structural and biochemical barrier to immunotherapeutic agents. To address the limitations of tumor penetration and distribution, and to enhance antitumor efficacy of immunotherapeutics, we p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::279e5a973682a50bda6fd9c4f4469096
https://doi.org/10.1021/acsanm.0c01506
https://doi.org/10.1021/acsanm.0c01506
Publikováno v:
Bioconjug Chem
Amine/thiol-reactive chemistries are commonly used to conjugate antibodies to pharmaceuticals or nanoparticles. Yet, these conjugation strategies often result in unfavorable outcomes such as heterogeneous antibody display with hindered biological act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42da2a21a38a572a8b272b97843527b6
https://doi.org/10.1021/acs.bioconjchem.0c00118
https://doi.org/10.1021/acs.bioconjchem.0c00118
Autor:
Christine M Minnar, Paul L Chariou, Lucas A Horn, Kristin C Hicks, Claudia Palena, Jeffrey Schlom, Sofia R Gameiro
Publikováno v:
Journal for immunotherapy of cancer. 10(6)
BackgroundImmune checkpoint blockade (ICB) has achieved unprecedented success in treating multiple cancer types. However, clinical benefit remains modest for most patients with solid malignancies due to primary or acquired resistance. Tumor-intrinsic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::051377cbeba44f4fd34e2c9e519eac5d
https://pubmed.ncbi.nlm.nih.gov/35764364
https://pubmed.ncbi.nlm.nih.gov/35764364
Autor:
Lucas A. Horn, Paul L. Chariou, Sofia R. Gameiro, Haiyan Qin, Masafumi Iida, Kristen Fousek, Thomas J. Meyer, Margaret Cam, Dallas Flies, Solomon Langermann, Jeffrey Schlom, Claudia Palena
Publikováno v:
Journal of Clinical Investigation. 132
Collagens in the extracellular matrix (ECM) provide a physical barrier to tumor immune infiltration, while also acting as a ligand for immune inhibitory receptors. Transforming growth factor-β (TGF-β) is a key contributor to shaping the ECM by stim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfe8ba482eacad3a24b37863b21ea970
https://doi.org/10.1172/jci155148
https://doi.org/10.1172/jci155148