Zobrazeno 1 - 10
of 108
pro vyhledávání: '"Paul L, Swiecicki"'
Autor:
Kenneth R. Gundle, Karthik Rajasekaran, Jeffrey Houlton, Gary B. Deutsch, Thomas J. Ow, Robert G. Maki, John Pang, Cherie-Ann O. Nathan, Daniel Clayburgh, Jason G. Newman, Elyse Brinkmann, Michael J. Wagner, Seth M. Pollack, Matthew J. Thompson, Ryan J. Li, Vikas Mehta, Bradley A. Schiff, Barry I. Wenig, Paul L. Swiecicki, Alice L. Tang, Jessica L. Davis, Annemieke van Zante, Jessica A. Bertout, Wendy Jenkins, Atticus Turner, Marc Grenley, Connor Burns, Jason P. Frazier, Angela Merrell, Kimberly H. W. Sottero, Jonathan M. J. Derry, Kate C. Gillespie, Bre Mills, Richard A. Klinghoffer
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Introduction: Drug development is systemically inefficient. Research and development costs for novel therapeutics average hundreds of millions to billions of dollars, with the overall likelihood of approval estimated to be as low as 6.7% for oncology
Externí odkaz:
https://doaj.org/article/df356ddd88154387999a5c867f337370
Autor:
Laila A. Gharzai, Julia Pakela, Elizabeth M. Jaworski, Issam El Naqa, Jennifer Shah, Peter G. Hawkins, Matthew E. Spector, Carol R. Bradford, Steven B. Chinn, Kelly Malloy, Robbi Kupfer, Andrew Shuman, Robert Morrison, Chaz L. Stucken, Andrew Rosko, Mark E. Prince, Keith Casper, Avraham Eisbruch, Gregory Wolf, Paul L. Swiecicki, Francis Worden, Michelle L. Mierzwa
Publikováno v:
Clinical and Translational Radiation Oncology, Vol 33, Iss , Pp 30-36 (2022)
Background and purpose: Bioselection with induction chemotherapy in larynx cancer is associated with excellent larynx preservation and disease-specific survival but requires visual inspection of the primary tumor. We retrospectively compare clinical
Externí odkaz:
https://doaj.org/article/36489a02909c47fdb394460ab8d41d1e
Autor:
Kayte Spector-Bagdady, Madison Kent, Chris D Krenz, Collin Brummel, Paul L Swiecicki, J Chad Brenner, Andrew G Shuman
Publikováno v:
JMIR Cancer, Vol 8, Iss 2, p e35033 (2022)
BackgroundThe genomic frontier continues to revolutionize the practice of oncology. Advances in cancer biology from tumorigenesis to treatment resistance are driven by the molecular underpinnings of malignancy. The framing of precision oncology as bo
Externí odkaz:
https://doaj.org/article/259028fd7d794d15bd441ee986744e24
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Cancer biomarkers are a promising tool for cancer detection, personalization of therapy, and monitoring of treatment response or recurrence. “Liquid biopsy” commonly refers to minimally invasive or non-invasive sampling of a bodily fluid (i.e., b
Externí odkaz:
https://doaj.org/article/e181a5e91acf4b5293f3aa981760392d
Autor:
Joshua D. Smith, Megan L. Ludwig, Apurva D. Bhangale, Collin Brummel, Paul L. Swiecicki, Francis P. Worden, Steven B. Chinn, Chaz L. Stucken, Andrew J. Rosko, Mark E. P. Prince, Kelly M. Malloy, Keith A. Casper, Carol R. Bradford, Douglas B. Chepeha, Jennifer Shah, Caitlin A. Schonewolf, Jonathon B. McHugh, Mukesh K. Nyati, Avraham Eisbruch, Michelle L. Mierzwa, Matthew E. Spector, J. Chad Brenner
Publikováno v:
Head & Neck. 45:1281-1287
Autor:
Neil D. Gross, David M. Miller, Nikhil I. Khushalani, Vasu Divi, Emily S. Ruiz, Evan J. Lipson, Friedegund Meier, Yungpo B. Su, Paul L. Swiecicki, Jennifer Atlas, Jessica L. Geiger, Axel Hauschild, Jennifer H. Choe, Brett G.M. Hughes, Dirk Schadendorf, Vishal A. Patel, Jade Homsi, Janis M. Taube, Annette M. Lim, Renata Ferrarotto, Howard L. Kaufman, Frank Seebach, Israel Lowy, Suk-Young Yoo, Melissa Mathias, Keilah Fenech, Hyunsil Han, Matthew G. Fury, Danny Rischin
Publikováno v:
N Engl J Med
BACKGROUND: In a pilot study involving patients with cutaneous squamous-cell carcinoma, a high percentage of patients had a pathological complete response with the use of two doses of neoadjuvant cemiplimab before surgery. Data from a phase 2 study a
Autor:
Michelle L. Mierzwa, Madhava Aryal, Choonik Lee, Matthew Schipper, Monica VanTil, Krystal Morales, Paul L. Swiecicki, Keith A. Casper, Kelly M. Malloy, Matthew E. Spector, Andrew G. Shuman, Steven B. Chinn, Mark E.P. Prince, Chaz L. Stucken, Andrew J. Rosko, Theodore S. Lawrence, J. Chad Brenner, Benjamin Rosen, Caitlin A. Schonewolf, Jennifer Shah, Avraham Eisbruch, Francis P. Worden, Yue Cao
Publikováno v:
Clin Cancer Res
Purpose: We conducted a randomized phase II multicenter clinical trial to test the hypothesis that physiologic MRI-based radiotherapy (RT) dose escalation would improve the outcome of patients with poor prognosis head and neck cancer. Patients and Me
Publikováno v:
The Cancer Journal. 28:381-386
The WEE1 kinase family plays a crucial role in cell cycle regulation and DNA damage response pathways in malignant cells. Inhibition of WEE1 effectively overrides G2 cell cycle arrest and results in the accumulation of extensive DNA damage within div
Autor:
Amy L. Pasternak, Robinson Seda, Joseph Lipa, Rachel L. McDevitt, Oxana V. Crysler, Paul L. Swiecicki, Bryan J. Schneider, Brett Vanderwerff, N. Lynn Henry, John C. Krauss, Vaibhav Sahai, Daniel L. Hertz
Publikováno v:
Clinical Pharmacology & Therapeutics.
Autor:
Catherine T. Haring, Lulia A. Kana, Sarah M. Dermody, Collin Brummel, Jonathan B. McHugh, Keith A. Casper, Steven B. Chinn, Kelly M. Malloy, Michelle Mierzwa, Mark E. P. Prince, Andrew J. Rosko, Jennifer Shah, Chaz L. Stucken, Andrew G. Shuman, J. Chad Brenner, Matthew E. Spector, Francis P. Worden, Paul L. Swiecicki
Publikováno v:
Cancer.