Výsledky vyhledávání - "Paul L, Klarenbeek"

Akademický článek

Do Relapses Follow ANCA Rises? A Systematic Review and Meta-Analysis on the Value of Serial ANCA Level Evaluation

Autor: Aram Al-Soudi, Yosta Vegting, Paul L. Klarenbeek, Marc L. Hilhorst

Publikováno v: Frontiers in Medicine, Vol 9 (2022)

ObjectivesANCA-vasculitis (AAV) patients frequently suffer from relapses and risk subsequent organ damage. There is much debate on the value of serial ANCA level evaluation to monitor disease activity. We aimed to evaluate the association between ANC

Externí odkaz: https://doaj.org/article/5ae4028aadf345948b7da646681e42d3

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Akademický článek

Eomes broadens the scope of CD8 T-cell memory by inhibiting apoptosis in cells of low affinity.

Autor: Inga Kavazović, Hongya Han, Giulia Balzaretti, Erik Slinger, Niels A W Lemmermann, Anja Ten Brinke, Doron Merkler, Jan Koster, Yenan T Bryceson, Niek de Vries, Stipan Jonjić, Paul L Klarenbeek, Bojan Polić, Eric Eldering, Felix M Wensveen

Publikováno v: PLoS Biology, Vol 18, Iss 3, p e3000648 (2020)

The memory CD8 T-cell pool must select for clones that bind immunodominant epitopes with high affinity to efficiently counter reinfection. At the same time, it must retain a level of clonal diversity to allow recognition of pathogens with mutated epi

Externí odkaz: https://doaj.org/article/44f011a2567046b1a91de7cf857789c9

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Akademický článek

The Germinal Center Milieu in Rheumatoid Arthritis: The Immunological Drummer or Dancer?

Autor: Dornatien C. Anang, Giulia Balzaretti, Antoine van Kampen, Niek de Vries, Paul L. Klarenbeek

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 19, p 10514 (2021)

Rheumatoid Arthritis (RA) is a chronic autoimmune disease characterized by joint inflammation, affecting approximately 1% of the general population. To alleviate symptoms and ameliorate joint damage, chronic use of immunosuppressives is needed. Howev

Externí odkaz: https://doaj.org/article/1726f507e577480b949ef951a5a934eb

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CXCR5

Publikováno v: Cellularmolecular immunology.

Gastrointestinal infections are a major cause for serious clinical complications in infants. The induction of antibody responses by B cells is critical for protective immunity against infections and requires CXCR5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::892631d60396a12f1919895e2a417626
https://pubmed.ncbi.nlm.nih.gov/36600048

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Akademický článek

Somatic Variation of T-Cell Receptor Genes Strongly Associate with HLA Class Restriction.

Autor: Paul L Klarenbeek, Marieke E Doorenspleet, Rebecca E E Esveldt, Barbera D C van Schaik, Neubury Lardy, Antoine H C van Kampen, Paul P Tak, Robert M Plenge, Frank Baas, Paul I W de Bakker, Niek de Vries

Publikováno v: PLoS ONE, Vol 10, Iss 10, p e0140815 (2015)

Every person carries a vast repertoire of CD4+ T-helper cells and CD8+ cytotoxic T cells for a healthy immune system. Somatic VDJ recombination at genomic loci that encode the T-cell receptor (TCR) is a key step during T-cell development, but how a s

Externí odkaz: https://doaj.org/article/b9e3d89697c6478a8a5861ba9009e7f5

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Spinning straw into gold: description of a disruptive rheumatology research platform inspired by the COVID-19 pandemic

Autor: Erik H Vogelzang, Femke Hooijberg, Sander W. Tas, Paul L. Klarenbeek, Gertjan Wolbink, Laura Boekel, Wouter H Bos

Publikováno v: Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-6 (2021)
Arthritis Research & Therapy

Clinical research projects often use traditional methods in which data collection and signing informed consent forms rely on patients’ visits to the research institutes. However, during challenging times when the medical community is in dire need o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac9ee2e886e92f8f182a2a0646487a1b
https://doi.org/10.1186/s13075-021-02574-z

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IgG4:IgG RNA ratio differentiates active disease from remission in granulomatosis with polyangiitis: a new disease activity marker? A cross-sectional and longitudinal study

Autor: A Al-Soudi, N. de Vries, Paul L. Klarenbeek, A. E. Hak, R.E. Esveldt, B.J.H. van den Born, Sander W. Tas, Marieke E. Doorenspleet, R. Van Vollenhoven, L. T. Burgemeister

Publikováno v: Arthritis Research & Therapy, Vol 21, Iss 1, Pp 1-11 (2019)
Arthritis research & therapy, 21(1). BioMed Central
Arthritis Research & Therapy

Objectives An important limitation in granulomatosis with polyangiitis (GPA) is the lack of disease activity markers. Immunoglobulin G4-positive (IgG4+) B cells and plasma cells are implicated in the pathogenesis of GPA. We hypothesized that the pres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed4c6a3763f14fd42cbb817b40fded33
http://link.springer.com/article/10.1186/s13075-018-1806-6

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Akademický článek

Regulatory T cells expanded from HIV-1-infected individuals maintain phenotype, TCR repertoire and suppressive capacity.

Autor: Mathieu Angin, Paul L Klarenbeek, Melanie King, Siddhartha M Sharma, Eshia S Moodley, Ashley Rezai, Alicja Piechocka-Trocha, Ildiko Toth, Andrew T Chan, Philip J Goulder, Thumbi Ndung'u, Douglas S Kwon, Marylyn M Addo

Publikováno v: PLoS ONE, Vol 9, Iss 2, p e86920 (2014)

While modulation of regulatory T cell (Treg) function and adoptive Treg transfer are being explored as therapeutic modalities in the context of autoimmune diseases, transplantation and cancer, their role in HIV-1 pathogenesis remains less well define

Externí odkaz: https://doaj.org/article/4c6ef61a90974ecb86cee4cc9aa33f4d

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Intestinal CD8+ T cell responses are abundantly induced early in human development but show impaired cytotoxic effector capacities

Autor: Carla M. S. Ribeiro, Roel Bakx, A. J. Highton, J.B. van Goudoever, Adrian F. Sagebiel, R. R. C. E. Schreurs, Paul L. Klarenbeek, Fenja L Steinert, M. J. Bunders, Teunis B. H. Geijtenbeek, Daniel Perez, Agata Drewniak, Konrad Reinshagen

Publikováno v: Schreurs, R R C E, Sagebiel, A F, Steinert, F L, Highton, A J, Klarenbeek, P L, Drewniak, A, Bakx, R, The, S M L, Ribeiro, C M S, Perez, D, Reinshagen, K, Geijtenbeek, T B H, van Goudoever, J B & Bunders, M J 2021, ' Intestinal CD8+ T cell responses are abundantly induced early in human development but show impaired cytotoxic effector capacities ', Mucosal Immunology, vol. 14, no. 3, pp. 605-614 . https://doi.org/10.1038/s41385-021-00382-x
Mucosal Immunology, 14(3), 605-614. Nature Publishing Group
Mucosal immunology, 14(3), 605-614. Nature Publishing Group

Gastrointestinal viral infections are a major global cause of disease and mortality in infants. Cytotoxic CD8+ T cells are critical to achieve viral control. However, studies investigating the development of CD8+ T cell immunity in human tissues earl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9bba5d833fd8f5328e42d5761035dec
https://research.vumc.nl/en/publications/a7222ddc-580e-48d3-be1f-f93713596153

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