Zobrazeno 1 - 10 of 29 pro vyhledávání: '"Paul L, Black"'
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Akademický článek
Validation of the SCID-hu Thy/Liv mouse model with four classes of licensed antiretrovirals.
Autor: Cheryl A Stoddart, Cheryl A Bales, Jennifer C Bare, George Chkhenkeli, Sofiya A Galkina, April N Kinkade, Mary E Moreno, José M Rivera, Rollie E Ronquillo, Barbara Sloan, Paul L Black
Publikováno v: PLoS ONE, Vol 2, Iss 7, p e655 (2007)
The SCID-hu Thy/Liv mouse model of HIV-1 infection is a useful platform for the preclinical evaluation of antiviral efficacy in vivo. We performed this study to validate the model with representatives of all four classes of licensed antiretrovirals.E
Externí odkaz: https://doaj.org/article/fb047b72aca54c4094161004657b21ea
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2
Cofactor Mimics as Selective Inhibitors of NAD-dependent Inosine Monophospate Dehydrogenase (IMPDH) - the Major Therapeutic Target
Autor: Hiremagalur N. Jayaram, Krzysztof W. Pankiewicz, Dipesh Risal, Lieven J. Stuyver, Paul L. Black, Barry M. Goldstein, Steven E. Patterson, Raymond F. Schinazi
Publikováno v: Current Medicinal Chemistry. 11:887-900
IMP dehydrogenase, the key enzyme in de novo synthesis of purine nucleotides, is an important therapeutic target. Three inhibitors of IMP dehydrogenase reached the market; ribavirin (Rebetol) a broad-spectrum antiviral agent, which in combination wit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e2f52b6b8279da2341db9f0f93aa969
https://doi.org/10.2174/0929867043455648
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3
Antiviral activity of biological response modifiers in a murine model of aids. requirement for augmentation of natural killer cell activity and synergy with oral AZT
Autor: Paul L. Black, Katherine M. McKinnon, Sharon L. Wooden, Michael A. Ussery
Publikováno v: International Journal of Immunopharmacology. 18:633-650
We employed the Rauscher murine leukemia virus (RMuLV) as a murine retrovirus model of AIDS, to test biological response modifiers (BRM) and antiviral agents for potential therapeutic activity against the human immunodeficiency virus (HIV). We examin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41ae099206808e433323a110993d427a
https://doi.org/10.1016/s0192-0561(96)00064-1
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4
Effect of tumor burden and route of administration on the immunotherapeutic properties of polyinosinic-polycytidylic acid stabilized with poly-l-lysine in carboxymethyl cellulose [Poly(I,C)-LC]
Autor: Robin Pennington, James E. Talmadge, Mark Schneider, Diethelm Hartmann, Henry Tribble, Hamblin Phillips, Paul L. Black
Publikováno v: International Journal of Immunopharmacology. 14:1341-1353
We examined the immunomodulatory and therapeutic activities of poly(I,C-LC. Mice received a subcutaneous (s.c.) injection of sufficient numbers of MBL-2 lymphoma cells to produce in 1 week either a high or low tumor burden. A week after tumor cell in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84761c7a1e47978ab3ac96791199cf41
https://doi.org/10.1016/0192-0561(92)90005-6
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5
Effect of Cyclophosphamide, Total Body Irradiation, and Zidovudine on Retrovirus Proliferation and Disease Progression in Murine AIDS
Autor: Arthur M. Krieg, Paul L. Black, Michael A. Ussery, Dennis M. Klinman, Jacqueline Conover
Publikováno v: AIDS Research and Human Retroviruses. 8:101-106
Murine acquired immunodeficiency syndrome (MAIDS) develops when C57B1/6 mice are inoculated with LP-BM5 murine leukemia viruses. Disease progression in these animals is characterized by lymphadenopathy, polyclonal B-cell activation, severe immunodefi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adaad64bfac0d5674cd3ca8232c0d464
https://doi.org/10.1089/aid.1992.8.101
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7
Validation of the SCID-hu Thy/Liv mouse model with four classes of licensed antiretrovirals
Autor: Barbara Sloan, Jose M. Rivera, Cheryl A. Bales, Mary E. Moreno, April N. Kinkade, Sofiya A. Galkina, Cheryl A. Stoddart, Rollie Ronquillo, George Chkhenkeli, Paul L. Black, Jennifer C. Bare
Publikováno v: PLoS ONE, Vol 2, Iss 7, p e655 (2007)
PloS one, vol 2, iss 7
PLoS ONE
Background The SCID-hu Thy/Liv mouse model of HIV-1 infection is a useful platform for the preclinical evaluation of antiviral efficacy in vivo. We performed this study to validate the model with representatives of all four classes of licensed antire
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e06c94bf160cab2dad670e3d59dd1835
http://europepmc.org/articles/PMC1925140?pdf=render
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8
Evaluation of therapies for hepatitis B virus in the HBV transgenic SCID mouse model
Autor: Shu Min Zhang, Raymond F. Schinazi, Milind Kamkolkar, Marcia M. Clayton, Paul L. Black, Mark A. Feitelson
Publisher Summary Hepatitis B virus (HBV) transgenic SCID mice support virus gene expression and replication. Chronic carriers of hepatitis B are at high risk of the developing hepatitis, cirrhosis, and hepatocellular carcinoma (HCC). These diseases
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c3cb42a15167f810d310352bd6338c3a
https://doi.org/10.1016/b978-044450986-4/50070-9
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10
Cell-based and animal models for hepatitis B and C viruses
Autor: Shlomo Dagan, Ehud Ilan, Paul L. Black, Raymond F. Schinazi, Xuejen Yao
Publikováno v: Antiviral chemistrychemotherapy. 10(3)
Reliable cell-based assays and animal models have been developed for evaluating agents against hepatitis B virus. Although much progress has been made, in vitro and in vivo assays for hepatitis C virus are still on the horizon. Advances towards estab
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fe1d078b29158f23b15963eb3ba2635
https://pubmed.ncbi.nlm.nih.gov/10431609
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