PreVenTB trial: protocol for evaluation of efficacy and safety of two vaccines VPM1002 and Immuvac (Mw) in preventing tuberculosis (TB) in healthy household contacts of newly diagnosed sputum smear-positive pulmonary TB patients: phase III, randomised, double-blind, three-arm placebo-controlled trial

Autor: Raman R Gangakhedkar, Ravindra Mohan Pandey, Rakesh Kumar, Randeep Guleria, Manjula Singh, Soumya Swaminathan, George D’Souza, Rashmi Rodrigues, Anand Krishnan, Sanghamitra Pati, Sudipta Mohakud, Anant Mohan, Ramesh Kumar, Prasanta Raghab Mohapatra, Parul Kodan, Rohit Sarin, Baijayantimala Mishra, Geeta Yadav, Deepak Gupta, Anuj Bhatnagar, Sriram Selvaraju, Ritu Gupta, Sandeep Patil, Sourin Bhuniya, Sanjay Mehendale, Samiran Panda, Subrata Kumar Palo, Debasish Hota, Sangeeta Sharma, Srikanth Tripathy, Kiran Katoch, Sindhu Joshi, Somashekar Narasimhaiah, Sangeeta Bhaskar, Rajni Rani, Abdul Mabood Khan, Urvashi B Singh, D K Mitra, Neelam Roy, Amitva Sen Gupta, Vikram Vohra, Neeta Singla, Vijaya Valluri Ansari, Chitra Iravatham, Shilpa Rakh, D K Prudhula, Chala Devi, N Rupa, K Sailaja, Sheela Godbole, Seema Sahay, Suchit Kamble, Megha Mamulwar, Arati Kishor Mane, Ashwini Vinod Shete, Abhijit Vasantrao Kadam, Vineet Chadha, S Uma Shankar, C Ravichandra, S K Tripathy, Dasarathi Das, Tahziba Hussain, B Dwibedi, P R Mohapatra, S C B Cuttack, M R Pattnaik, Sabita Mohapatra, Banu Rekha, Mohan Natarajan, P K Bhavani, D Bella Devaleenal, Syed Hisar, S Devarajulu Reddy, Paul Kumaran, Makhesh Kumar, Poorna Ganga Devi, Sunny Omkar Singh, Devi Pratyush, Vidushi Gupta, Parvathi

Publikováno v: BMJ Open, Vol 14, Iss 8 (2024)

Introduction Tuberculosis (TB) continues to be one of the deadliest infectious diseases over the centuries, killing more people worldwide than any other single infectious disease. There is an urgent need for additional strategies which can expedite e

Externí odkaz: https://doaj.org/article/0dfb68c186d44cbe9ab7313c02d81cab

Multi-Dimensionality Immunophenotyping Analyses of MAIT Cells Expressing Th1/Th17 Cytokines and Cytotoxic Markers in Latent Tuberculosis Diabetes Comorbidity

Autor: Gokul Raj Kathamuthu, Nathella Pavan Kumar, Kadar Moideen, Chandrakumar Dolla, Paul Kumaran, Subash Babu

Publikováno v: Pathogens, Vol 11, Iss 1, p 87 (2022)

Mucosal-associated invariant T (MAIT) cells are innate like, and play a major role in restricting disease caused by Mycobacterium tuberculosis (Mtb) disease before the activation of antigen-specific T cells. Additionally, the potential link and syner

Externí odkaz: https://doaj.org/article/f3d01425d8e34f9caacdb2af677076c6

Prediabetes is associated with the modulation of antigen-specific Th1/Tc1 and Th17/Tc17 responses in latent Mycobacterium tuberculosis infection.

Autor: Nathella Pavan Kumar, Kadar Moideen, Chandrakumar Dolla, Paul Kumaran, Subash Babu

Publikováno v: PLoS ONE, Vol 12, Iss 5, p e0178000 (2017)

Type 2 diabetes mellitus (DM) is associated with the down modulation of Th1, Th2 and Th17 responses in latent Mycobacterium tuberculosis infection but the role of prediabetes (PDM) in this setting is not well understood. To examine the role of CD4+ a

Externí odkaz: https://doaj.org/article/e5ce63059dcb472caf8b61ab1da8ef50

Expansion of parasite-specific CD4+ and CD8+ T cells expressing IL-10 superfamily cytokine members and their regulation in human lymphatic filariasis.

Autor: Rajamanickam Anuradha, Parakkal Jovvian George, Luke E Hanna, Paul Kumaran, Vedachalam Chandrasekaran, Thomas B Nutman, Subash Babu

Publikováno v: PLoS Neglected Tropical Diseases, Vol 8, Iss 4, p e2762 (2014)

Lymphatic filariasis (LF) is known to be associated with an increased production of IL-10. The role of the other IL-10 family members in the pathogenesis of infection and/or disease is not known.We examined the expression patterns of IL-10 family mem

Externí odkaz: https://doaj.org/article/b7eb26088d534e4b80662f9034aadc6a

Attenuation of toll-like receptor expression and function in latent tuberculosis by coexistent filarial infection with restoration following antifilarial chemotherapy.

Autor: Subash Babu, Sajid Q Bhat, N Pavan Kumar, R Anuradha, Paul Kumaran, P G Gopi, C Kolappan, V Kumaraswami, Thomas B Nutman

Publikováno v: PLoS Neglected Tropical Diseases, Vol 3, Iss 7, p e489 (2009)

Mycobacterium tuberculosis (Mtb) and filarial coinfection is highly prevalent, and the presence of filarial infections may regulate the Toll-like receptor (TLR)-dependent immune response needed to control Mtb infection. By analyzing the baseline and

Externí odkaz: https://doaj.org/article/5c893a83e6b44c518e67c778e118fe68