Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Paul Krolikowski"'
Autor:
Xi-Jie Dai, Paul Krolikowski, James I. Murray, Carolyn S. Wei, Peter K. Dornan, Andreas R. Rötheli, Seb Caille, Oliver R. Thiel, Austin G. Smith, Andrew T. Parsons
Publikováno v:
The Journal of Organic Chemistry. 87:8437-8444
An organocatalyzed, formal (3+3) cycloaddition reaction is described for the practical synthesis of substituted pyridines. Starting from readily available enamines and enal/ynal/enone substrates, the protocol affords tri- or tetrasubstituted pyridine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e1271b206782db094b974c62bc65c6e
https://doi.org/10.1021/acs.joc.2c00576
https://doi.org/10.1021/acs.joc.2c00576
Publikováno v:
Drug Metabolism Letters. 14:126-136
Introduction: A group of substituted benzothiazoles from a research project was found to have low microsomal clearance. However, these compounds had very high clearance in vivo. Methods: In the present study, the clearance mechanism of two of the str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c1f3e38fe37e26b7dc9eea448cce050
https://doi.org/10.2174/1872312814666210405101419
https://doi.org/10.2174/1872312814666210405101419
Publikováno v:
Crystal Growth & Design. 16:210-220
Total scattering pair distribution function (TSPDF) analysis of synchrotron X-ray diffraction data has been used to study the structural characteristics of amorphous lactose and its subsequent recrystallization on aging. This shows that the recrystal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c318b8a993ed2dd6e80ac4583f0c1df6
https://doi.org/10.1021/acs.cgd.5b01100
https://doi.org/10.1021/acs.cgd.5b01100
Autor:
Shawn Ayube, Hao Chen, Yohannes Teffera, Jacinthe Gingras, Paul L. Shaffer, Paul Krolikowski, Angel Guzman-Perez, Kristin L. Andrews, Hakan Gunaydin, Richard Thomas Lewis, Klaus Michelsen, Jiali Hu, Liyue Huang, Sonya G. Lehto, Pamela Pegman, Erin F. DiMauro, Howard Bregman, Shuyan Yi, Xin Huang, Maosheng Zhang, Matthew H. Plant, Jeffrey R. Simard
Publikováno v:
Journal of medicinal chemistry. 60(3)
Current pain therapeutics suffer from undesirable psychotropic and sedative side effects, as well as abuse potential. Glycine receptors (GlyRs) are inhibitory ligand-gated ion channels expressed in nerves of the spinal dorsal horn, where their activa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0578c8ef3924f9ebf3c9f90bbe82708
https://pubmed.ncbi.nlm.nih.gov/28001399
https://pubmed.ncbi.nlm.nih.gov/28001399
Autor:
Raju Subramanian, Paul Krolikowski, A. David Rodrigues, Thomas A. Baillie, Christopher R. Gibson, Rominder Singh, Conrad E. Raab, Cheri M. Brown, Kimberly Michel, Janice Brunner, Thomas H. Rushmore, Karen Richards, Edward J. Carlini, Patrice Ciecko, Aimee Michael, Catherine Boothe-Genthe, Charles C. Lin, Jennifer K. Adelsberger, Mona Parikh, Minh Luu
Publikováno v:
Drug Metabolism and Disposition. 33:1044-1051
Compound I [3-[5-(4-methanesulfonyl-piperazin-1-ylmethyl)-1H-indol-2-yl]-1H-quinolin-2-one] is a potent inhibitor of human kinase insert domain-containing receptor (KDR kinase), which is under investigation for the treatment of cancer. Bile duct-cann
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aedef78aee11b67707f1f492c1592d15
https://doi.org/10.1124/dmd.105.003913
https://doi.org/10.1124/dmd.105.003913
Autor:
Adria E. Colletti, Yohannes Teffera, Zhiyang Zhao, Paul Krolikowski, Jingzhou Liu, Loren Berry
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 42(4)
The mammalian target of rapamycin (mTOR) is a protein kinase that shows key involvement in age-related disease and promises to be a target for treatment of cancer. In the present study, the elimination of potent ATP-competitive mTOR inhibitor 3-(6-am
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be62c59b145c318340c2af58431ea811
https://pubmed.ncbi.nlm.nih.gov/24423753
https://pubmed.ncbi.nlm.nih.gov/24423753
Autor:
Paul Krolikowski, Kevin P. Bateman, Cheri M Maciolek, Sebastien Laliberte, Bennett Ma, Karsten Menzel, Christopher R. Gibson
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 39(5)
Setileuton [4-(4-fluorophenyl)-7-[({5-[(1S)-1-hydroxy-1-(trifluoromethyl)propyl]-1,3,4-oxadiazol-2-yl}amino)methyl]-2H-1-benzopyran-2-one] is a selective inhibitor of the 5-lipoxygenase enzyme, which is under investigation for the treatment of asthma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86cd61695a744d622d67d650ef50e2d3
https://pubmed.ncbi.nlm.nih.gov/21325431
https://pubmed.ncbi.nlm.nih.gov/21325431
Publikováno v:
Chemical research in toxicology. 20(1)
The cytotoxic effects of blattellaquinone (BTQ), a sex pheromone produced by adult female German cockroaches, have been studied using human lung adenocarcinoma A549 cells. 1,4-Benzoquinone (BQ), a toxic chemical implicated in benzene toxicity, was us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b5e861258a8b454b255dc066cc5469b
https://pubmed.ncbi.nlm.nih.gov/17226928
https://pubmed.ncbi.nlm.nih.gov/17226928
Publikováno v:
Acta Crystallographica Section A Foundations and Advances. 70:C864-C864
Lactose is a disaccharide sugar of galactose and glucose that is most commonly associated with milk. Its importance to the food and animal product industry cannot be overstated, as it is involved in aspects as diverse as baking, confectionary, and in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5eca933a45e548279dd5ef5db144787
https://doi.org/10.1107/s2053273314091359
https://doi.org/10.1107/s2053273314091359
Publikováno v:
Chemical Research in Toxicology; Jan2007, Vol. 20 Issue 1, p72-78, 7p