Výsledky vyhledávání

The Cutaneous Microbiome and Aspects of Skin Antimicrobial Defense System Resist Acute Treatment with Topical Skin Cleansers

Autor: Aimee M. Two, Tissa Hata, Paul Kotol, Teruaki Nakatsuji, Evangelia Arvanitidou, Richard L. Gallo, Laurence Du-Thumm

Publikováno v: Journal of Investigative Dermatology. 136:1950-1954

The human skin microbiome has been suggested to play an essential role in maintaining health by contributing to innate defense of the skin. These observations have inspired speculation that the use of common skin washing techniques may be detrimental

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fbe70e9ba626e86fa6b91eab3f866ab
https://doi.org/10.1016/j.jid.2016.06.612

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IL-4Rα Blockade by Dupilumab Decreases Staphylococcus aureus Colonization and Increases Microbial Diversity in Atopic Dermatitis

Autor: Jonathan I. Silverberg, Jennifer D. Hamilton, Alison Vrbanac, Richard L. Gallo, James G. Krueger, Marius Ardeleanu, Emma Guttman-Yassky, Chris Callewaert, Tomasz Kosciolek, Neil M.H. Graham, Teruaki Nakatsuji, Alan Menter, Robert Bissonnette, Thomas Hultsch, Paul Kotol, Gianluca Pirozzi, Rob Knight

Publikováno v: JOURNAL OF INVESTIGATIVE DERMATOLOGY

Dupilumab is a fully human antibody to interleukin-4 receptor alpha that improves the signs and symptoms of moderate to severe atopic dermatitis (AD). To determine the effects of dupilumab on Staphylococcus aureus colonization and microbial diversity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36febb8b090255c4c76faa6057834ea5
https://pubmed.ncbi.nlm.nih.gov/31864429

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Cathelicidin, kallikrein 5, and serine protease activity is inhibited during treatment of rosacea with azelaic acid 15% gel

Autor: Richard L. Gallo, Alvin B. Coda, Tissa Hata, Julie C Harper, James Q Del Rosso, Jeremiah Miller, Faiza Shafiq, David Audish, Paul Kotol, Kenshi Yamasaki, Aimee M. Two

Publikováno v: Journal of the American Academy of Dermatology. 69:570-577

Background Excess cathelicidin and kallikrein 5 (KLK5) have been hypothesized to play a role in the pathophysiology of rosacea. Objective We sought to evaluate the effects of azelaic acid (AzA) on these elements of the innate immune system. Methods G

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4e045533dd19ed044f687e27ade5c81
https://doi.org/10.1016/j.jaad.2013.05.019

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A randomized controlled double-blind investigation of the effects of vitamin D dietary supplementation in subjects with atopic dermatitis

Autor: Patricia A. Taylor, Richard L. Gallo, Filamer D Kabigting, Doru T Alexandrescu, Jon M. Hanifin, Tissa Hata, David Audish, Donald Y.M. Leung, Karen Kesler, Paul Kotol, Alvin B. Coda, Leela Aertker, Mark Boguniewicz, Jeremiah Miller

Publikováno v: Journal of the European Academy of Dermatology and Venereology. 28:781-789

Subjects with atopic dermatitis (AD) have defects in antimicrobial peptide (AMP) production possibly contributing to an increased risk of infections. In laboratory models, vitamin D can alter innate immunity by increasing AMP production.To determine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22161e12d336fc2de8187fc3e24b171d
https://doi.org/10.1111/jdv.12176

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Neutrophil differentiation into a unique hybrid population exhibiting dual phenotype and functionality of neutrophils and dendritic cells

Autor: Nobuyasu Mayuzumi, Paul Kotol, Richard L. Gallo, Shuo Geng, Hironori Matsushima, Ran Lu, Benjamin J. Chojnacki, Yi Yao, Takashi Okamoto, Akira Takashima, Toru Miyazaki

Publikováno v: Blood. 121:1677-1689

Neutrophils have been reported to acquire surface expression of MHC class II and co-stimulatory molecules as well as T-cell stimulatory activities when cultured with selected cytokines. However, cellular identity of those unusual neutrophils showing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::020dcb755e7bdc73a55e292974b98e6f
https://doi.org/10.1182/blood-2012-07-445189

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Cathelicidin antimicrobial peptide LL-37 in psoriasis enables keratinocyte reactivity against TLR9 ligands

Autor: Beda Mühleisen, Keiji Iwatsuki, Kenshi Yamasaki, Shin Morizane, Tissa Hata, Yumi Aoyama, Masamoto Murakami, Paul Kotol, Richard L. Gallo

Publikováno v: The Journal of investigative dermatology

Here we show that keratinocytes in psoriatic lesional skin express increased Toll-like receptor (TLR) 9 that similarly localizes with elevated expression of the cathelicidin antimicrobial peptide LL-37. In culture, normal human keratinocytes exposed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6938f3b15a94289b1b59ba0f9340e9fc
http://europepmc.org/articles/PMC3220926

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