The ansamycin antibiotic, rifamycin SV, inhibits BCL6 transcriptional repression and forms a complex with the BCL6-BTB/POZ domain.

Autor: Sian E Evans, Benjamin T Goult, Louise Fairall, Andrew G Jamieson, Paul Ko Ferrigno, Robert Ford, John W R Schwabe, Simon D Wagner

Publikováno v: PLoS ONE, Vol 9, Iss 3, p e90889 (2014)

BCL6 is a transcriptional repressor that is over-expressed due to chromosomal translocations, or other abnormalities, in ∼40% of diffuse large B-cell lymphoma. BCL6 interacts with co-repressor, SMRT, and this is essential for its role in lymphomas.

Externí odkaz: https://doaj.org/article/fe23d50d068949fe973cb08ce7f2fb15

Sensitive and selective Affimer-functionalised interdigitated electrode-based capacitive biosensor for Her4 protein tumour biomarker detection

Autor: Pawan Jolly, Christian Tiede, Paul Ko Ferrigno, Sunil K. Arya, Pedro Estrela, Pavel Zhurauski, Darren C. Tomlinson

Publikováno v: Biosensors and Bioelectronics
Zhurauski, P, Arya, S, Jolly, P, Tiede, C, Tomlinson, D, Ko-Ferrigno, P & Estrela, P 2018, ' Sensitive and selective Affimer-functionalised interdigitated electrode-based capacitive biosensor for Her4 protein tumour biomarker detection ', Biosensors and Bioelectronics, vol. 108, pp. 1-8 . https://doi.org/10.1016/j.bios.2018.02.041

A novel Affimer-functionalised interdigitated electrode-based capacitive biosensor platform was developed for detection and estimation of Her4, a protein tumour biomarker, in undiluted serum. An anti-Her4 Affimer with a C-terminal cysteine was used t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4230d54a7bbb1f8e642cfa38a79a7a6e
https://pubmed.ncbi.nlm.nih.gov/29482002

Affimer proteins are versatile and renewable affinity reagents

Autor: Michael E. Webb, Alastair D. Smith, Gina A. Smith, Mark J. Drinkhill, Sophie J Heseltine, Margaret A. Knowles, Filomena Esteves, Joanne E. Nettleship, Sandra M. Bell, Michael A. Harrison, Raj Prasad, Vikesh Patel, Alexander Balls, Paul Ko Ferrigno, Danah AlQallaf, Ruth E. Hughes, Christian Tiede, Louise Coletta, Hannah F. Kyle, Anna A Tang, Matthew Johnson, Ashley P.E. Roberts, Imeshi Wijetunga, Raymond J. Owens, Alistair Curd, Jonathan D. Lippiat, Laura C. Zanetti-Domingues, Geoffrey W. Platt, Darren C. Tomlinson, Rebecca L. Ross, Sarah A. Goodchild, Naomi Gibson, Nicola Ingram, Robert Bedford, Michael J. McPherson, Sreenivasan Ponnambalam, Thomas Taylor, Marisa L. Martin-Fernandez, Iain W. Manfield, Sarah R. Needham, Yashar Sadigh, Azhar Maqbool, Thomas P. Peacock, Michelle Peckham, Heather L. Martin, Robin S. Bon

Publikováno v: eLife, Vol 6 (2017)
eLife

Molecular recognition reagents are key tools for understanding biological processes and are used universally by scientists to study protein expression, localisation and interactions. Antibodies remain the most widely used of such reagents and many sh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a266f4782feecdb6c1e445111cec72b0
https://ora.ox.ac.uk/objects/uuid:fcf56628-19a1-4b5e-af7c-f8e5da55b375

Peptide aptamers as new tools to modulateclathrin-mediated internalisation -- inhibition ofMT1-MMP internalisation.

Autor: Wickramasinghe, Rochana D.¹, Paul Ko Ferrigno^1,2, Roghi, Christian³ chr26@cam.ac.uk

Publikováno v: BMC Cell Biology. 2010, Vol. 11, p58-72. 15p.

Peptide aptamers in label-free protein detection: 2. Chemical optimization and detection of distinct protein isoforms

Autor: Rachel Humphreys, Jason J. Davis, Paul Ko Ferrigno, Jan Tkac, Anthony T. Buxton, Tracy Lee

The early detection and diagnosis of cancer lies central to successful treatment and improved patient outcome. Current techniques are limited by the nature of the biological receptor and the assays available. This paper reports the use of novel biolo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43a4221d314abe8d2aa13895328b6b4a
https://doi.org/10.1021/ac802513n