Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Paul Kievit"'
Autor:
Darian T. Carroll, Allie Miller, Jennifer Fuhr, Joseph M. Elsakr, Valerie Ricciardi, Alexa N. Del Bene, Stedman Stephens, Evan Krystofiak, Sarah R. Lindsley, Melissa Kirigiti, Diana L. Takahashi, Tyler A. Dean, Stephanie R. Wesolowski, Carrie E. McCurdy, Jacob E. Friedman, Kjersti M. Aagaard, Paul Kievit, Maureen Gannon
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
IntroductionUsing a non-human primate (NHP) model of maternal Western-style diet (mWSD) feeding during pregnancy and lactation, we previously reported altered offspring beta:alpha cell ratio in vivo and insulin hyper-secretion ex vivo. Mitochondria a
Externí odkaz:
https://doaj.org/article/2aefe612d931437fb2599f63ef8e7bf0
Autor:
Alan C. Rupp, Abigail J. Tomlinson, Alison H. Affinati, Warren T. Yacawych, Allison M. Duensing, Cadence True, Sarah R. Lindsley, Melissa A. Kirigiti, Alexander MacKenzie, Joseph Polex-Wolf, Chien Li, Lotte Bjerre Knudsen, Randy J. Seeley, David P. Olson, Paul Kievit, Martin G. Myers Jr.
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 19 (2023)
The adipose-derived hormone leptin acts via its receptor (LepRb) in the brain to control energy balance. A potentially unidentified population of GABAergic hypothalamic LepRb neurons plays key roles in the restraint of food intake and body weight by
Externí odkaz:
https://doaj.org/article/8811d7c0ec574a9aaa88aff9c4f1a0f9
Autor:
Michael J. Nash, Evgenia Dobrinskikh, Taylor K. Soderborg, Rachel C. Janssen, Diana L. Takahashi, Tyler A. Dean, Oleg Varlamov, Jon D. Hennebold, Maureen Gannon, Kjersti M. Aagaard, Carrie E. McCurdy, Paul Kievit, Bryan C. Bergman, Kenneth L. Jones, Eric M. Pietras, Stephanie R. Wesolowski, Jacob E. Friedman
Publikováno v:
Cell Reports, Vol 42, Iss 4, Pp 112393- (2023)
Summary: Maternal overnutrition increases inflammatory and metabolic disease risk in postnatal offspring. This constitutes a major public health concern due to increasing prevalence of these diseases, yet mechanisms remain unclear. Here, using nonhum
Externí odkaz:
https://doaj.org/article/61f8abfb16c94221819b0fcca9d1aea3
Autor:
Michael J. Nash, Evgenia Dobrinskikh, Rachel C. Janssen, Mark A. Lovell, Deborah A. Schady, Claire Levek, Kenneth L. Jones, Angelo D’Alessandro, Paul Kievit, Kjersti M. Aagaard, Carrie E. McCurdy, Maureen Gannon, Jacob E. Friedman, Stephanie R. Wesolowski
Publikováno v:
Hepatology Communications, Vol 7, Iss 2, Pp e0014-e0014 (2023)
Pediatric NAFLD has distinct and variable pathology, yet causation remains unclear. We have shown that maternal Western-style diet (mWSD) compared with maternal chow diet (CD) consumption in nonhuman primates produces hepatic injury and steatosis in
Externí odkaz:
https://doaj.org/article/6bcad75da676422bbcbdb90a6e13d609
Autor:
Joseph M. Elsakr, Sifang Kathy Zhao, Valerie Ricciardi, Tyler A. Dean, Diana L. Takahashi, Elinor Sullivan, Stephanie R. Wesolowski, Carrie E. McCurdy, Paul Kievit, Jacob E. Friedman, Kjersti M. Aagaard, Digna R. Velez Edwards, Maureen Gannon
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract The prevalence of maternal obesity is increasing in the United States. Offspring born to women with obesity or poor glycemic control have greater odds of becoming obese and developing metabolic disease later in life. Our group has utilized a
Externí odkaz:
https://doaj.org/article/aa19a82e9f5149fe9535985f2027cb5b
Autor:
Michael J. Nash, Evgenia Dobrinskikh, Sean A. Newsom, Ilhem Messaoudi, Rachel C. Janssen, Kjersti M. Aagaard, Carrie E. McCurdy, Maureen Gannon, Paul Kievit, Jacob E. Friedman, Stephanie R. Wesolowski
Publikováno v:
JCI Insight, Vol 6, Iss 24 (2021)
Maternal obesity affects nearly one-third of pregnancies and is a major risk factor for nonalcoholic fatty liver disease (NAFLD) in adolescent offspring, yet the mechanisms behind NAFLD remain poorly understood. Here, we demonstrate that nonhuman pri
Externí odkaz:
https://doaj.org/article/74abddaa583647bc9452d4301229be48
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Central administration of fibroblast growth factor-1 (FGF1) results in long-lasting resolution of hyperglycemia in various rodent models, but the pre- and postsynaptic mechanisms mediating the central effects of FGF1 are unknown. Here we utilize elec
Externí odkaz:
https://doaj.org/article/3cca6b7b8c344ac4a50427b03e27d420
Autor:
Brandon L. Roberts, Baylin J. Bennett, Camdin M. Bennett, Julie M. Carroll, Louise S. Dalbøge, Colin Hall, Wafa Hassouneh, Kristy M. Heppner, Melissa A. Kirigiti, Sarah R. Lindsley, Katherine G. Tennant, Cadence A. True, Andrew Whittle, Anitra C. Wolf, Charles T. Roberts, Jr., Mads Tang-Christensen, Mark W. Sleeman, Michael A. Cowley, Kevin L. Grove, Paul Kievit
Publikováno v:
Molecular Metabolism, Vol 26, Iss , Pp 18-29 (2019)
Objective: Reelin (RELN) is a large glycoprotein involved in synapse maturation and neuronal organization throughout development. Deficits in RELN signaling contribute to multiple psychological disorders, such as autism spectrum disorder, schizophren
Externí odkaz:
https://doaj.org/article/2fb89f157ba64298a2342ca376aaca21
Autor:
Joseph M. Elsakr, Jennifer C. Dunn, Katherine Tennant, Sifang Kathy Zhao, Karly Kroeten, Raymond C. Pasek, Diana L. Takahashi, Tyler A. Dean, Digna R. Velez Edwards, Carrie E. McCurdy, Kjersti M. Aagaard, Alvin C. Powers, Jacob E. Friedman, Paul Kievit, Maureen Gannon
Publikováno v:
Molecular Metabolism, Vol 25, Iss , Pp 73-82 (2019)
Objective: In humans, offspring of women who are overweight or obese are more likely to develop metabolic disease later in life. Studies in lower animal species reveal that a calorically-dense maternal diet is associated with alterations in islet cel
Externí odkaz:
https://doaj.org/article/59c889a547274a3b82f1ccc31a532c7e
Autor:
Stephanie R. Wesolowski, Christopher M. Mulligan, Rachel C. Janssen, Peter R. Baker, II, Bryan C. Bergman, Angelo D'Alessandro, Travis Nemkov, Kenneth N. Maclean, Hua Jiang, Tyler A. Dean, Diana L. Takahashi, Paul Kievit, Carrie E. McCurdy, Kjersti M. Aagaard, Jacob E. Friedman
Publikováno v:
Molecular Metabolism, Vol 18, Iss , Pp 25-41 (2018)
Objective: Non-alcoholic fatty liver disease (NAFLD) risk begins in utero in offspring of obese mothers. A critical unmet need in this field is to understand the pathways and biomarkers underlying fetal hepatic lipotoxicity and whether maternal dieta
Externí odkaz:
https://doaj.org/article/a28561519af14a2b8a154ec639481f85