Zobrazeno 1 - 10
of 312
pro vyhledávání: '"Paul Kellam"'
Autor:
Marcos C. Miranda, Elizabeth Kepl, Mary Jane Navarro, Chengbo Chen, Max Johnson, Kaitlin R. Sprouse, Cameron Stewart, Anne Palser, Adian Valdez, Deleah Pettie, Claire Sydeman, Cassandra Ogohara, John C. Kraft, Minh Pham, Michael Murphy, Sam Wrenn, Brooke Fiala, Rashmi Ravichandran, Daniel Ellis, Lauren Carter, Davide Corti, Paul Kellam, Kelly Lee, Alexandra C. Walls, David Veesler, Neil P. King
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-14 (2024)
Abstract We previously described a two-component protein nanoparticle vaccine platform that displays 60 copies of the SARS-CoV-2 spike protein RBD (RBD-NP). The vaccine, when adjuvanted with AS03, was shown to elicit robust neutralizing antibody and
Externí odkaz:
https://doaj.org/article/649dcf2c588340c39547078121604655
Autor:
Stephen Baker, Aishwarya Krishna, Sophie Higham, Plamena Naydenova, Siobhan O’Leary, Josefin Bartholdson Scott, Katherine Harcourt, Sally Forrest, David Goulding, To Nguyen Thi Nguyen, Nguyen Duc Toan, Elizaveta Alekseeva, Qingqing Zhou, Ilaria Andreozzi, Barbara Sobotic, Hannah Craig, Vivian Wong, Nichola Forrest-Owen, Dana Moreno Sanchez, Claire Pearce, Leah Roberts, Simon Watson, Simon Clare, Mili Estee Torok, Gordon Dougan, Paul Kellam, John S. Tregoning, Stephen T. Reece
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract The use of monoclonal antibodies for the control of drug resistant nosocomial bacteria may alleviate a reliance on broad spectrum antimicrobials for treatment of infection. We identify monoclonal antibodies that may prevent infection caused
Externí odkaz:
https://doaj.org/article/61a68b7e9f41452c92f657bdd46b3b43
Autor:
Julia Ludwig, Stephen W. Scally, Giulia Costa, Sandro Hoffmann, Rajagopal Murugan, Jana Lossin, Katherine Prieto, Anna Obraztsova, Nina Lobeto, Blandine Franke-Fayard, Chris J. Janse, Celia Lebas, Nicolas Collin, Spela Binter, Paul Kellam, Elena A. Levashina, Hedda Wardemann, Jean-Philippe Julien
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-14 (2023)
Abstract The development of an effective and durable vaccine remains a central goal in the fight against malaria. Circumsporozoite protein (CSP) is the major surface protein of sporozoites and the target of the only licensed Plasmodium falciparum (Pf
Externí odkaz:
https://doaj.org/article/e21e8d2652bd4aaba4120441ac9e5abb
Autor:
Elaine Thai, Rajagopal Murugan, Špela Binter, Clare Burn Aschner, Katherine Prieto, Audrey Kassardjian, Anna S. Obraztsova, Ryu Won Kang, Yevel Flores-Garcia, Shamika Mathis-Torres, Kan Li, Gillian Q. Horn, Richard H.C. Huntwork, Judith M. Bolscher, Marloes H.C. de Bruijni, Robert Sauerwein, S. Moses Dennison, Georgia D. Tomaras, Fidel Zavala, Paul Kellam, Hedda Wardemann, Jean-Philippe Julien
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113330- (2023)
Summary: IGHV3-33-encoded antibodies are prevalent in the human humoral response against the Plasmodium falciparum circumsporozoite protein (PfCSP). Among VH3-33 antibodies, cross-reactivity between PfCSP major repeat (NANP), minor (NVDP), and juncti
Externí odkaz:
https://doaj.org/article/08227defc9c24c6faea6294d29f2de60
Autor:
Eve Richardson, Špela Binter, Miha Kosmac, Marie Ghraichy, Valentin von Niederhäusern, Aleksandr Kovaltsuk, Jacob D Galson, Johannes Trück, Dominic F Kelly, Charlotte M Deane, Paul Kellam, Simon J Watson
Publikováno v:
eLife, Vol 12 (2023)
Immunoglobulin loci-transgenic animals are widely used in antibody discovery and increasingly in vaccine response modelling. In this study, we phenotypically characterised B-cell populations from the Intelliselect Transgenic mouse (Kymouse) demonstra
Externí odkaz:
https://doaj.org/article/8edf1acdf29a48b99e78fa6ee6f633dc
Autor:
My V. T. Phan, Charles N. Agoti, Patrick K. Munywoki, Grieven P. Otieno, Mwanajuma Ngama, Paul Kellam, Matthew Cotten, D. James Nokes
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Pneumonia remains a major cause of mortality and morbidity. Most molecular diagnoses of viruses rely on polymerase chain reaction (PCR) assays that however can fail due to primer mismatch. We investigated the performance of routine virus dia
Externí odkaz:
https://doaj.org/article/b8674ec557a840ed853590141e4613ce
Autor:
Iga Kucharska, Špela Binter, Rajagopal Murugan, Stephen W Scally, Julia Ludwig, Katherine Prieto, Elaine Thai, Giulia Costa, Kan Li, Gillian Q Horn, Yevel Flores-Garcia, Alexandre Bosch, Taylor Sicard, John L Rubinstein, Fidel Zavala, S Moses Dennison, Georgia D Tomaras, Elena A Levashina, Paul Kellam, Hedda Wardemann, Jean-Philippe Julien
Publikováno v:
PLoS Pathogens, Vol 18, Iss 11, p e1010999 (2022)
Antibodies targeting the human malaria parasite Plasmodium falciparum circumsporozoite protein (PfCSP) can prevent infection and disease. PfCSP contains multiple central repeating NANP motifs; some of the most potent anti-infective antibodies against
Externí odkaz:
https://doaj.org/article/8c8d7d9367ac4e39a094144bab03ffbb
Autor:
Julia Ludwig, Stephen W. Scally, Giulia Costa, Sandro Hoffmann, Rajagopal Murugan, Jana Lossin, Katherine Prieto, Anna Obraztsova, Nina Lobeto, Blandine Franke-Fayard, Chris J. Janse, Celia Lebas, Nicolas Collin, Spela Binter, Paul Kellam, Elena A. Levashina, Hedda Wardemann, Jean-Philippe Julien
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/b04564d582c142d78add34d9a8e7e92b
Autor:
Neneh Sallah, Wendell Miley, Nazzarena Labo, Tommy Carstensen, Segun Fatumo, Deepti Gurdasani, Martin O. Pollard, Alexander T. Dilthey, Alexander J. Mentzer, Vickie Marshall, Elena M. Cornejo Castro, Cristina Pomilla, Elizabeth H. Young, Gershim Asiki, Martin L. Hibberd, Manjinder Sandhu, Paul Kellam, Robert Newton, Denise Whitby, Inês Barroso
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Disease prognosis after infection with Kaposi’s sarcoma-associated herpesvirus and Epstein-Barr Virus is highly variable. Here the authors carry out epidemiological and genetic analysis of a Ugandan cohort and suggest complex interactions may influ
Externí odkaz:
https://doaj.org/article/bed7120367f24202b2ee1e7cdbe065db
Autor:
Irene Bassano, Swee Hoe Ong, Maximo Sanz-Hernandez, Michal Vinkler, Adebabay Kebede, Olivier Hanotte, Ebele Onuigbo, Mark Fife, Paul Kellam
Publikováno v:
BMC Genomics, Vol 20, Iss 1, Pp 1-14 (2019)
Abstract Background The interferon-induced transmembrane (IFITM) protein family comprises a class of restriction factors widely characterised in humans for their potent antiviral activity. Their biological activity is well documented in several anima
Externí odkaz:
https://doaj.org/article/c75ecc1afd3147acae3b42503d220244