Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Paul Kalitsis"'
Publikováno v:
Open Biology, Vol 9, Iss 12 (2019)
Topoisomerase III beta (TOP3B) is one of the least understood members of the topoisomerase family of proteins and remains enigmatic. Our recent data shed light on the function and relevance of TOP3B to disease. A homozygous deletion for the TOP3B gen
Externí odkaz:
https://doaj.org/article/0c774b2dce174478a6b8d963cc8daa9b
Autor:
Cedric S. Tremblay, Jesslyn Saw, Sung Kai Chiu, Nicholas C. Wong, Kirill Tsyganov, Sarah Ghotb, Alison N. Graham, Feng Yan, Andrew A. Guirguis, Stefan E. Sonderegger, Nicole Lee, Paul Kalitsis, John Reynolds, Stephen B. Ting, David R. Powell, Stephen M. Jane, David J. Curtis
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Cell cycle kinetics of pre-leukemic stem cells (pre-LSCs) may be an important determinant of clonal evolution and therapeutic resistance. Here, the AUs use a transgenic T-ALL mouse model that allows non-dividing cells to be tracked and identify a sub
Externí odkaz:
https://doaj.org/article/b35a3f8af939445d8e61e8a054430aae
Autor:
Damien F Hudson, David J Amor, Amber Boys, Kathy Butler, Lorna Williams, Tao Zhang, Paul Kalitsis
Publikováno v:
PLoS Genetics, Vol 12, Iss 12, p e1006483 (2016)
Bloom syndrome is a recessive human genetic disorder with features of genome instability, growth deficiency and predisposition to cancer. The only known causative gene is the BLM helicase that is a member of a protein complex along with topoisomerase
Externí odkaz:
https://doaj.org/article/13a2d069e43a41f2937e21354a20ca35
Autor:
Michelle C W Tang, Shelley A Jacobs, Deidre M Mattiske, Yu May Soh, Alison N Graham, An Tran, Shu Ly Lim, Damien F Hudson, Paul Kalitsis, Moira K O'Bryan, Lee H Wong, Jeffrey R Mann
Publikováno v:
PLoS Genetics, Vol 11, Iss 2, p e1004964 (2015)
Histones package DNA and regulate epigenetic states. For the latter, probably the most important histone is H3. Mammals have three near-identical H3 isoforms: canonical H3.1 and H3.2, and the replication-independent variant H3.3. This variant can acc
Externí odkaz:
https://doaj.org/article/fbdbd16026c44294a31791d6aec3ee14
Autor:
Alison N Graham, Paul Kalitsis
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86875 (2014)
The centromere is an essential chromosomal structure that is required for the faithful distribution of replicated chromosomes to daughter cells. Defects in the centromere can compromise the stability of chromosomes resulting in segregation errors. We
Externí odkaz:
https://doaj.org/article/2e0f358a1dd74d5c886a4ca14c8b021d
Autor:
Jonathan Ip, Paul Canham, K H Andy Choo, Yoshimi Inaba, Shelley A Jacobs, Paul Kalitsis, Deidre M Mattiske, Jane Ng, Richard Saffery, Nicholas C Wong, Lee H Wong, Jeffrey R Mann
Publikováno v:
PLoS Genetics, Vol 8, Iss 9, p e1002919 (2012)
Reduced DNA methylation has been reported in DICER1-deficient mouse ES cells. Reductions seen at pericentric satellite repeats have suggested that siRNAs are required for the proper assembly of heterochromatin. More recent studies have postulated tha
Externí odkaz:
https://doaj.org/article/6f5656b252bc45f69ef5080e7c43c94c
Autor:
David I. Francis, Zornitza Stark, Ingrid E. Scheffer, Tiong Yang Tan, Krithika Murali, Lyndon Gallacher, David J. Amor, Himanshu Goel, Lilian Downie, Chloe A. Stutterd, Emma I. Krzesinski, Anand Vasudevan, Ralph Oertel, Vida Petrovic, Amber Boys, Vivian Wei, Trent Burgess, Karen Dun, Karen L. Oliver, Anne Baxter, Anna Hackett, Samantha Ayres, Sebastian Lunke, Paul Kalitsis, Meaghan Wall
Publikováno v:
European journal of human genetics : EJHG.
We aimed to determine whether SNP-microarray genomic testing of saliva had a greater diagnostic yield than blood for pathogenic copy number variants (CNVs). We selected patients who underwent CMA testing of both blood and saliva from 23,289 blood and
Autor:
Maheshi Udugama, Benjamin Vinod, F Lyn Chan, Linda Hii, Andrew Garvie, Philippe Collas, Paul Kalitsis, David Steer, Partha P Das, Pratibha Tripathi, Jeffrey R Mann, Hsiao P J Voon, Lee H Wong
Publikováno v:
Nucleic acids research. 50(8)
Histone H3.3 is an H3 variant which differs from the canonical H3.1/2 at four residues, including a serine residue at position 31 which is evolutionarily conserved. The H3.3 S31 residue is phosphorylated (H3.3 S31Ph) at heterochromatin regions includ
Publikováno v:
Proc Natl Acad Sci U S A
Topoisomerase IIα (TOP2A) is a core component of mitotic chromosomes and important for establishing mitotic chromosome condensation. The primary roles of TOP2A in mitosis have been difficult to decipher due to its multiple functions across the cell
Autor:
Nicholas C. Wong, Cedric S. Tremblay, Kirill Tsyganov, Stephen M. Jane, Andrew A. Guirguis, Sung Kai Chiu, Stephen B. Ting, Alison N. Graham, David J. Curtis, John V. Reynolds, Stefan Eugen Sonderegger, David R. Powell, Feng Yan, Paul Kalitsis, Nicole K. Lee, Sarah Ghotb, Jesslyn Saw
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Nature Communications
Nature Communications
Pre-leukemic stem cells (pre-LSCs) give rise to leukemic stem cells through acquisition of additional gene mutations and are an important source of relapse following chemotherapy. We postulated that cell-cycle kinetics of pre-LSCs may be an important