Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Paul K. Pallaghy"'
Publikováno v:
Influenza and Other Respiratory Viruses. 5:89-98
Please cite this paper as: Pearce et al. (2011) Understanding mortality in the 1918–1919 influenza pandemic in England and Wales. Influenza and Other Respiratory Viruses 5(2), 89–98. Background The causes of recurrent waves in the 1918–1919 inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6dba4490df76e4e5dab3aaeefb9a1643
https://doi.org/10.1111/j.1750-2659.2010.00186.x
https://doi.org/10.1111/j.1750-2659.2010.00186.x
Autor:
Paul K. Pallaghy, Dianne Alewood, Raymond S. Norton, Paul F. Alewood, Graham M. Nicholson, Liesl C. Birinyi-Strachan
Publikováno v:
Biochemistry. 42:12933-12940
Delta-atracotoxin-Ar1a (delta-ACTX-Ar1a) is the major polypeptide neurotoxin isolated from the venom of the male Sydney funnel-web spider, Atrax robustus. This neurotoxin targets both insect and mammalian voltage-gated sodium channels, where it compe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9764f9cff2a8741f0d98fe8547f22ede
https://doi.org/10.1021/bi030091n
https://doi.org/10.1021/bi030091n
Autor:
Paul K. Pallaghy, Raymond S. Norton
Publikováno v:
Biopolymers. 54:173-179
Contryphan-R, from venom of the cone-shell Conus radiatus, represents a novel cyclic peptide scaffold onto which residues may be grafted to mimic unrelated protein surfaces. Three substitutions were made at the x and X positions of the disulfide-brid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::059d26ae380fb79da35372113745e862
https://doi.org/10.1002/1097-0282(200009)54:3<173::aid-bip30>3.0.co
https://doi.org/10.1002/1097-0282(200009)54:3<173::aid-bip30>3.0.co
Autor:
James A. Angus, Raymond S. Norton, Paul K. Pallaghy, Michael J. Lew, James P. Flinn, Roger Murphy
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1434:177-190
ω-Conotoxin GVIA (GVIA), an N-type calcium channel blocker from the cone shell Conus geographus , is a 27 residue polypeptide cross-linked by three disulfide bonds. Here, we report the synthesis, structural analysis by 1 H NMR and bioassay of analog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2e1a6d3ac9c09aff3a72433c731a9e9
https://doi.org/10.1016/s0167-4838(99)00165-x
https://doi.org/10.1016/s0167-4838(99)00165-x
Autor:
Paul K. Pallaghy, Raymond S. Norton
Publikováno v:
The Journal of Peptide Research. 53:343-351
The polypeptide omega-conotoxin GVIA (GVIA) is an N-type calcium channel blocker from the venom of Conus geographus, a fish-hunting cone shell. Here we describe a high-resolution solution structure of this member of the 'inhibitor cystine knot' prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32df511695ea7e32cbe1cd27985a3dd8
https://doi.org/10.1034/j.1399-3011.1999.00040.x
https://doi.org/10.1034/j.1399-3011.1999.00040.x
Autor:
Raymond S. Norton, Jonathan B. Baell, Paul K. Pallaghy, James A. Angus, Christine E. Wright, Michael J. Lew
Publikováno v:
Drug Development Research. 46:206-218
The ω-conotoxins are small polypeptides (of around 25 residues) cross- linked by three disulfide bonds. At least two of these, ω-conotoxins GVIA and MVIIA, are potent and selective blockers of N-type voltage-gated calcium channels. Administered int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dde89d8978c7fe34f27e6664600d508e
https://doi.org/10.1002/(sici)1098-2299(199903/04)46:3/4<206::aid-ddr6>3.0.co
https://doi.org/10.1002/(sici)1098-2299(199903/04)46:3/4<206::aid-ddr6>3.0.co
Autor:
Paul K. Pallaghy, James A. Angus, James P. Flinn, Raymond S. Norton, Sarah L. Whorlow, Roger Murphy, Christine E. Wright, Michael J. Lew
Publikováno v:
Journal of Biological Chemistry. 272:12014-12023
The structure-function relationships of the N-type calcium channel blocker, ω-conotoxin GVIA (GVIA), have been elucidated by structural, binding and in vitro and in vivo functional studies of alanine-substituted analogues of the native molecule. Ala
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06bb11fdd07cb038a7b7d4dfbdf6859e
https://doi.org/10.1074/jbc.272.18.12014
https://doi.org/10.1074/jbc.272.18.12014
Publikováno v:
Nature Structural & Molecular Biology. 3:317-320
The first structure of a sea anemone potassium channel toxin reveals how a novel structural scaffold can be used to present key functional groups for channel blockade.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c1b4775d105bc95bad89d2833345a10
https://doi.org/10.1038/nsb0496-317
https://doi.org/10.1038/nsb0496-317
Publikováno v:
BMC Infectious Diseases, Vol 10, Iss 1, p 128 (2010)
BMC Infectious Diseases
BMC Infectious Diseases
Background The ecology of influenza may be more complex than is usually assumed. For example, despite multiple waves in the influenza pandemic of 1918-19, many people in urban locations were apparently unaffected. Were they unexposed, or protected by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feb22f7cbf3e73b9870bc809d0cb03c2
http://www.biomedcentral.com/1471-2334/10/128
http://www.biomedcentral.com/1471-2334/10/128
Publikováno v:
Modern Physics Letters A. :2271-2280
We investigate a CP violating observable, the μ-polarization, in η → μ+μ− in several models with the standard gauge group. The CP violating parameters are constrained by the experimental upper bound on the neutron electric dipole moment. Amon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ffee039e6069e5fe55361f95ad1a962b
https://doi.org/10.1142/s0217732390002602
https://doi.org/10.1142/s0217732390002602