Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Paul K Potter"'
Autor:
Carlos Aguilar, Debbie Williams, Ramakrishna Kurapati, Rasneer S. Bains, Philomena Mburu, Andy Parker, Jackie Williams, Danilo Concas, Hilda Tateossian, Andrew R. Haynes, Gareth Banks, Pratik Vikhe, Ines Heise, Marie Hutchison, Gemma Atkins, Simon Gillard, Becky Starbuck, Simona Oliveri, Andrew Blake, Siddharth Sethi, Saumya Kumar, Tanaya Bardhan, Jing-Yi Jeng, Stuart L. Johnson, Lara F. Corns, Walter Marcotti, Michelle Simon, Sara Wells, Paul K. Potter, Heena V. Lad
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110170- (2024)
Summary: Despite some evidence indicating diverse roles of whirlin in neurons, the functional corollary of whirlin gene function and behavior has not been investigated or broadly characterized. A single nucleotide variant was identified from our rece
Externí odkaz:
https://doaj.org/article/8421d27753b841d7bc0fb0382fdbd3c7
Autor:
Katherine R Bull, Andrew J Rimmer, Owen M Siggs, Lisa A Miosge, Carla M Roots, Anselm Enders, Edward M Bertram, Tanya L Crockford, Belinda Whittle, Paul K Potter, Michelle M Simon, Ann-Marie Mallon, Steve D M Brown, Bruce Beutler, Christopher C Goodnow, Gerton Lunter, Richard J Cornall
Publikováno v:
PLoS Genetics, Vol 9, Iss 1, p e1003219 (2013)
Forward genetics screens with N-ethyl-N-nitrosourea (ENU) provide a powerful way to illuminate gene function and generate mouse models of human disease; however, the identification of causative mutations remains a limiting step. Current strategies de
Externí odkaz:
https://doaj.org/article/8853c90c0f7c420f926eb8c8ec5b55e2
Autor:
Michael T Cheeseman, Hayley E Tyrer, Debbie Williams, Tertius A Hough, Paras Pathak, Maria R Romero, Helen Hilton, Sulzhan Bali, Andrew Parker, Lucie Vizor, Tom Purnell, Kate Vowell, Sara Wells, Mahmood F Bhutta, Paul K Potter, Steve D M Brown
Publikováno v:
PLoS Genetics, Vol 7, Iss 10, p e1002336 (2011)
Otitis media with effusion (OME) is the commonest cause of hearing loss in children, yet the underlying genetic pathways and mechanisms involved are incompletely understood. Ventilation of the middle ear with tympanostomy tubes is the commonest surgi
Externí odkaz:
https://doaj.org/article/12d63bc415b249f7b612e2389bb1acab
Publikováno v:
Cartilage Tissue Engineering ISBN: 9781071628386
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ca7f9c7eed94383af625b47a06ad6b5
https://doi.org/10.1007/978-1-0716-2839-3_26
https://doi.org/10.1007/978-1-0716-2839-3_26
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2598
In this chapter, we describe an induced model of osteoarthritis in mice, frequently employed in the study of this disease. We outline in detail the surgical induction of disease and preparation of samples for histological assessment of disease.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b57ac7256b0c6a2bd7d9aa6e17090672
https://pubmed.ncbi.nlm.nih.gov/36355305
https://pubmed.ncbi.nlm.nih.gov/36355305
This article gives an overview about the aging in rodents and how rodents can be used for aging modelling. The article starts with more general consideration about the modelling and some basic background. It is followed by the review of the most comm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f4a72b6e2ba87d412a892cf32c47330
https://doi.org/10.1016/b978-0-12-801238-3.11433-3
https://doi.org/10.1016/b978-0-12-801238-3.11433-3
Autor:
Paul K, Potter
Publikováno v:
Current aging science.
Ageing is generally viewed as a detrimental phenotype; with age comes increasing susceptibility to disease and frailty. Recent data also suggests that disease can result in an increase in ageing phenotypes suggesting a positive feedback loop. It is c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::1f6100fbe7f58d50f216cea4bd25cf57
https://pubmed.ncbi.nlm.nih.gov/25902451
https://pubmed.ncbi.nlm.nih.gov/25902451
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 844
Deciphering the contribution of individual genes and in turn pathways to cellular processes can be complicated and is often based on prior knowledge or assumptions of gene function. Phenotype-driven mutagenesis screens based around n-ethyl-n-nitrosur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cef9433c98c3dbf09f9c5bd4de49e506
https://pubmed.ncbi.nlm.nih.gov/22262431
https://pubmed.ncbi.nlm.nih.gov/22262431
Autor:
Amy S. Findlay, Roderick N. Carter, Becky Starbuck, Lisa McKie, Klára Nováková, Peter S. Budd, Margaret A. Keighren, Joseph A. Marsh, Sally H. Cross, Michelle M. Simon, Paul K. Potter, Nicholas M. Morton, Ian J. Jackson
Publikováno v:
Disease Models & Mechanisms, Vol 11, Iss 12 (2018)
Isocitrate dehydrogenase (IDH) is an enzyme required for the production of α-ketoglutarate from isocitrate. IDH3 generates the NADH used in the mitochondria for ATP production, and is a tetramer made up of two α, one β and one γ subunit. Loss-of-
Externí odkaz:
https://doaj.org/article/4019a0f8c71d4c0193216ceecc055644
Autor:
Paul K. Potter, Michael R. Bowl, Prashanthini Jeyarajan, Laura Wisby, Andrew Blease, Michelle E. Goldsworthy, Michelle M. Simon, Simon Greenaway, Vincent Michel, Alun Barnard, Carlos Aguilar, Thomas Agnew, Gareth Banks, Andrew Blake, Lauren Chessum, Joanne Dorning, Sara Falcone, Laurence Goosey, Shelley Harris, Andy Haynes, Ines Heise, Rosie Hillier, Tertius Hough, Angela Hoslin, Marie Hutchison, Ruairidh King, Saumya Kumar, Heena V. Lad, Gemma Law, Robert E. MacLaren, Susan Morse, Thomas Nicol, Andrew Parker, Karen Pickford, Siddharth Sethi, Becky Starbuck, Femke Stelma, Michael Cheeseman, Sally H. Cross, Russell G. Foster, Ian J. Jackson, Stuart N. Peirson, Rajesh V. Thakker, Tonia Vincent, Cheryl Scudamore, Sara Wells, Aziz El-Amraoui, Christine Petit, Abraham Acevedo-Arozena, Patrick M. Nolan, Roger Cox, Anne-Marie Mallon, Steve D. M. Brown
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Random mutagenesis can uncover novel genes involved in phenotypic traits. Here the authors perform a large-scale phenotypic screen on over 100 mouse strains generated by ENU mutagenesis to identify mice with age-related diseases, which they attribute
Externí odkaz:
https://doaj.org/article/fa97ab87303c498f824c8286a0325379