Výsledky vyhledávání

Akademický článek

Competitive binding of STATs to receptor phospho-Tyr motifs accounts for altered cytokine responses

Autor: Stephan Wilmes, Polly-Anne Jeffrey, Jonathan Martinez-Fabregas, Maximillian Hafer, Paul K Fyfe, Elizabeth Pohler, Silvia Gaggero, Martín López-García, Grant Lythe, Charles Taylor, Thomas Guerrier, David Launay, Suman Mitra, Jacob Piehler, Carmen Molina-París, Ignacio Moraga

Publikováno v: eLife, Vol 10 (2021)

Cytokines elicit pleiotropic and non-redundant activities despite strong overlap in their usage of receptors, JAKs and STATs molecules. We use IL-6 and IL-27 to ask how two cytokines activating the same signaling pathway have different biological rol

Externí odkaz: https://doaj.org/article/036f2f9b6d674d24920c5291fa65c2f9

Zobrazit plný text záznamu

Akademický článek

Kinetics of cytokine receptor trafficking determine signaling and functional selectivity

Autor: Jonathan Martinez-Fabregas, Stephan Wilmes, Luopin Wang, Maximillian Hafer, Elizabeth Pohler, Juliane Lokau, Christoph Garbers, Adeline Cozzani, Paul K Fyfe, Jacob Piehler, Majid Kazemian, Suman Mitra, Ignacio Moraga

Publikováno v: eLife, Vol 8 (2019)

Cytokines activate signaling via assembly of cell surface receptors, but it is unclear whether modulation of cytokine-receptor binding parameters can modify biological outcomes. We have engineered IL-6 variants with different affinities to gp130 to i

Externí odkaz: https://doaj.org/article/1b051ad15afd4701b89407a5956a40df

Zobrazit plný text záznamu

Akademický článek

Structural insights into IL-11-mediated signalling and human IL6ST variant-associated immunodeficiency

Autor: Scott Gardner, Yibo Jin, Paul K. Fyfe, Tomas B. Voisin, Junel Sotolongo Bellón, Elizabeth Pohler, Jacob Piehler, Ignacio Moraga, Doryen Bubeck

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)

Abstract IL-11 and IL-6 activate signalling via assembly of the cell surface receptor gp130; however, it is unclear how signals are transmitted across the membrane to instruct cellular responses. Here we solve the cryoEM structure of the IL-11 recept

Externí odkaz: https://doaj.org/article/bbc396d2171b448a8f4b408bf1d66f66

Zobrazit plný text záznamu

Akademický článek

Pseudomonas aeruginosa 4-amino-4-deoxychorismate lyase: spatial conservation of an active site tyrosine and classification of two types of enzyme.

Autor: Patrick E F O'Rourke, Thomas C Eadsforth, Paul K Fyfe, Sharon M Shepherd, William N Hunter

Publikováno v: PLoS ONE, Vol 6, Iss 9, p e24158 (2011)

4-Amino-4-deoxychorismate lyase (PabC) catalyzes the formation of 4-aminobenzoate, and release of pyruvate, during folate biosynthesis. This is an essential activity for the growth of gram-negative bacteria, including important pathogens such as Pseu

Externí odkaz: https://doaj.org/article/4542b7068e75494b96f4f6ea81c5c9a4

Zobrazit plný text záznamu

Structural insights into the assembly and activation of the IL-27 signalling complex

Autor: Yibo Jin, Paul K Fyfe, Scott Gardner, Stephan Wilmes, Doryen Bubeck, Ignacio Moraga

Interleukin 27 (IL-27) is a heterodimeric cytokine that elicits potent immuno-suppressive responses. Comprised of EBI3 and p28 subunits, IL-27 binds GP130 and IL-27Rα receptor chains to activate the JAK/STAT signalling cascade. However, how these re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55fbbc178bafecde87b8227dc17ae0ff
http://hdl.handle.net/10044/1/98306