Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Paul J. Zavodny"'
Autor:
Stephen R. Indelicato, Nicholas J Murgoloa, Aileen Schilling, Steven H Weiner, Susan Sehring, Richard W. Chapman, Chung-Her Jenha, Xiomara Fernandez, Diljeet Athwal, Spencer J Emtage, Mary Ann Coxa, Sue Stephens, Mark W. Bodmer, Jacqueline M Carter, Dawn Stelts, Chuan-Chu Choua, J. A. Zurcher, William Kreutner, Ted T Kunga, Michael Minnicozzi, Nancy Genatt, Satwant K. Narula, Peter J. Mauser, Robert W. Egan, S. Shane Taremi, Paul J. Zavodny, Petro Mary E
Publikováno v:
Arzneimittelforschung. 49:779-790
This report describes the development and the biology of Sch 55700, a humanized monoclonal antibody to human IL-5 (hIL-5). Sch 55700 was synthesized using CDR (complementarity determining regions) grafting technology by incorporating the antigen reco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ecd5539c9bec5537f2d898f89b07ce1
https://doi.org/10.1055/s-0031-1300502
https://doi.org/10.1055/s-0031-1300502
Autor:
Petro Mary E, Charlene Desquitado, Martin A. Schwarz, Satwant K. Narula, Benedict Gomes, Karen Du, Chung-Her Jenh, Charles A. Lunn, Brian Wilburn, Paul J. Zavodny, Daniel Lundell, Maria T. Wiekowski, Mary Ann Cox, Kyle Palmer, Chuan-Chu Chou
Publikováno v:
Biochemical and Biophysical Research Communications. 330:467-473
The human P2Y6 receptor (hP2Y6) is a member of the G protein-coupled pyrimidinergic P2 receptor family that responds specifically to the extracellular nucleotide uridine diphosphate (UDP). Recently, the hP2Y6 receptor has been reported to mediate mon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce8e59600e68e876cc7851b66e047a5c
https://doi.org/10.1016/j.bbrc.2005.03.004
https://doi.org/10.1016/j.bbrc.2005.03.004
Autor:
Galya Vassileva, Petro Mary E, Long Cui, Inhou Chu, Satwant K. Narula, Andrei Golovko, Lily Yang, Amin A. Nomeir, Catherine Pugliese-Sivo, Paul J. Zavodny, Li-Kang Zhang, Joseph A. Kozlowski, Xian Liang, Chuan-Chu Chou, Eva-Pia Reich
Publikováno v:
European Journal of Immunology. 35:1027-1036
The KCNN4 potassium-ion channel has been reported to play an important role in regulating antigen-induced T cell effector functions in vitro. This study presents the first evidence that a selective KCNN4 blocker, TRAM-34, confers protection against e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5698f5b7c12e773218892db03ee8d7f4
https://doi.org/10.1002/eji.200425954
https://doi.org/10.1002/eji.200425954
Autor:
E. J. Remarque, Chuan-Chu Chou, B. A. ‘t Hart, Jayaram R. Tagat, Michel P.M. Vierboom, Julie M. Strizki, Catherine Pugliese-Sivo, Steensma Ruo, Paul J. Zavodny, Margreet Jonker, Satwant K. Narula, Stuart W. McCombie, Liesbeth Celebi-Paul
Publikováno v:
Arthritis & Rheumatism. 52:627-636
Objective Collagen-induced arthritis (CIA) in the rhesus monkey is a nonhuman primate model of rheumatoid arthritis (RA). The close phylogenetic relationship between humans and the rhesus monkey makes this model useful for the preclinical safety and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c4058f0b9e8df37959f63d244776a49
https://doi.org/10.1002/art.20850
https://doi.org/10.1002/art.20850
Autor:
James Fossetta, Charles A. Lunn, Xuedong Fan, Brian J. Lavey, Gregory Deno, Daniel Lundell, Paul J. Zavodny, Pradip R. Das, R. William Hipkin, Waldemar Gonsiorek
Publikováno v:
British Journal of Pharmacology. 142:851-860
Sphingosine-1-phosphate (S1P) is a bioactive lipid that affects a variety of cellular processes through both its actions as a second messenger and via activation of a family of G protein-coupled receptors (S1P(1-5)). The study of S1P receptor pharmac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eee620d1c8b1342c15985824df66120f
https://doi.org/10.1038/sj.bjp.0705856
https://doi.org/10.1038/sj.bjp.0705856
Autor:
Waldemar Gonsiorek, William Hipkin, Paul J. Zavodny, Guodong Chen, Shirley A. Pomponi, Mahesh Patel, Vincent P. Gullo, Tze-Ming Chan, Amy E. Wright, Shu-Wei Yang, Birendra N. Pramanik, Min Chu
Publikováno v:
The Journal of Antibiotics. 56:783-786
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcd855390edc070f912df72113d21404
https://doi.org/10.7164/antibiotics.56.783
https://doi.org/10.7164/antibiotics.56.783
Autor:
Paul J. Zavodny, Chuan-Chu Chou, Jay S. Fine, Catherine Pugliese-Sivo, Petro Mary E, Waldemar Gonsiorek, Martin A. Schwarz, Liza Davies, R. William Hipkin, Gregory Deno
Publikováno v:
British Journal of Pharmacology. 137:663-675
C-C chemokine receptor-1 (CCR1) has been implicated in mediating a variety of inflammatory conditions including multiple sclerosis and organ rejection. Although originally referred to as the MIP-1alpha/RANTES receptor, CCR1 is quite promiscuous and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54c2fe40c03a2c1e7937167a63063c87
https://doi.org/10.1038/sj.bjp.0704907
https://doi.org/10.1038/sj.bjp.0704907
Autor:
Tianhong Lu, Chuan-Chu Chou, Catherine Pugliese-Sivo, William Hipkin, Paul J. Zavodny, Waldemar Gonsiorek, Mary Ann Cox, Satwant K. Narula, Chung-Her Jenh
Publikováno v:
Cytokine. 15:113-121
The CXC chemokine CXCL13, known as BCA-1 (B cell-attracting chemokine 1) or BLC (B-lymphocyte chemoattractant), has been identified as an efficacious attractant selective for B lymphocytes. The chemokine receptor BLR1 (Burkitt's lymphoma receptor 1)/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cb9feec795276c4d785f071a494968f
https://doi.org/10.1006/cyto.2001.0923
https://doi.org/10.1006/cyto.2001.0923
Autor:
Chung-Her Jenh, Waldemar Gonsiorek, Mary Ann Cox, Paul J. Zavodny, Jay S. Fine, Satwant K. Narula, R. William Hipkin
Publikováno v:
Molecular Pharmacology. 59:707-715
The human CXC chemokines IP-10 (10-kDa interferon-inducible protein), MIG (monokine induced by human interferon-gamma), and I-TAC (interferon-inducible T cell alpha chemoattractant) attract lymphocytes through activation of CXCR3. In the studies pres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6081f4ae2c16cde15939ab7795b73ddc
https://doi.org/10.1124/mol.59.4.707
https://doi.org/10.1124/mol.59.4.707
Publikováno v:
Inflammation. 25:61-67
The intracellular signaling pathways involved in human monocyte chemotaxis toward a variety of chemoattractant molecules were evaluated using selected pharmacological agents. Neither phosphatidylinositol-3-kinase (PI3K) or extracellular signal-regula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd68823a4fb2f4f394b3344c3837d235
https://doi.org/10.1023/a:1007152903135
https://doi.org/10.1023/a:1007152903135