Zobrazeno 1 - 10
of 243
pro vyhledávání: '"Paul J. Utz"'
Autor:
Cecilia Fahlquist-Hagert, Thomas R. Wittenborn, Ewa Terczyńska-Dyla, Kristian Savstrup Kastberg, Emily Yang, Alysa Nicole Rallistan, Quinton Raymond Markett, Gudrun Winther, Sofie Fonager, Lasse F. Voss, Mathias K. Pedersen, Nina van Campen, Alexey Ferapontov, Lisbeth Jensen, Jinrong Huang, John D. Nieland, Cees E. van der Poel, Johan Palmfeldt, Michael C. Carroll, Paul J. Utz, Yonglun Luo, Lin Lin, Søren E. Degn
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Circumstantial evidence suggests that B cells may instruct T cells to break tolerance. Here, to test this hypothesis, we used a murine model in which a single B cell clone precipitates an autoreactive response resembling systemic lupus eryth
Externí odkaz:
https://doaj.org/article/77b3e9364b6c4ef5993ede3e01fc8946
Autor:
Samantha Slight-Webb, Kevin Thomas, Miles Smith, Catriona A. Wagner, Susan Macwana, Aleksandra Bylinska, Michele Donato, Mai Dvorak, Sarah E. Chang, Alex Kuo, Peggie Cheung, Laurynas Kalesinskas, Ananthakrishnan Ganesan, Denis Dermadi, Carla J. Guthridge, Wade DeJager, Christian Wright, Mariko H. Foecke, Joan T. Merrill, Eliza Chakravarty, Cristina Arriens, Holden T. Maecker, Purvesh Khatri, Paul J. Utz, Judith A. James, Joel M. Guthridge
Publikováno v:
JCI Insight, Vol 8, Iss 16 (2023)
Systemic lupus erythematosus (SLE) affects 1 in 537 Black women, which is >2-fold more than White women. Black patients develop the disease at a younger age, have more severe symptoms, and have a greater chance of early mortality. We used a multiomic
Externí odkaz:
https://doaj.org/article/e17965113ade415ab50fbba3c6fd56ef
Autor:
Allan Feng, Emily Y. Yang, Andrew Reese Moore, Shaurya Dhingra, Sarah Esther Chang, Xihui Yin, Ruoxi Pi, Elisabeth K.M. Mack, Sara Völkel, Reinhard Geßner, Margrit Gündisch, Andreas Neubauer, Harald Renz, Sotirios Tsiodras, Paraskevi C. Fragkou, Adijat A. Asuni, Joseph E. Levitt, Jennifer G. Wilson, Michelle Leong, Jennifer H. Lumb, Rong Mao, Kassandra Pinedo, Jonasel Roque, Christopher M. Richards, Mikayla Stabile, Gayathri Swaminathan, Maria L. Salagianni, Vasiliki Triantafyllia, Wilhelm Bertrams, Catherine A. Blish, Jan E. Carette, Jennifer Frankovich, Eric Meffre, Kari Christine Nadeau, Upinder Singh, Taia T. Wang, Eline T. Luning Prak, Susanne Herold, Evangelos Andreakos, Bernd Schmeck, Chrysanthi Skevaki, Angela J. Rogers, Paul J. Utz
Publikováno v:
JCI Insight, Vol 8, Iss 3 (2023)
The widespread presence of autoantibodies in acute infection with SARS-CoV-2 is increasingly recognized, but the prevalence of autoantibodies in non–SARS-CoV-2 infections and critical illness has not yet been reported. We profiled IgG autoantibodie
Externí odkaz:
https://doaj.org/article/0af4f2fd58fe44f2af104cc8699674cb
Autor:
Kathleen D. Kolstad, Avani Khatri, Michele Donato, Sarah E. Chang, Shufeng Li, Virginia D. Steen, Paul J. Utz, Purvesh Khatri, Lorinda Chung
Publikováno v:
Arthritis Research & Therapy, Vol 24, Iss 1, Pp 1-8 (2022)
Abstract Background Pulmonary arterial hypertension (PAH) affects approximately 10% of patients with systemic sclerosis (SSc) and is a leading cause of death. We sought to identify serum cytokine signatures that risk stratify SSc patients for this po
Externí odkaz:
https://doaj.org/article/3b0b12de3d724266987b57bf13d38a16
Autor:
Roshani Sinha, Mai Dvorak, Ananthakrishnan Ganesan, Larry Kalesinskas, Charlotte M. Niemeyer, Christian Flotho, Kathleen M. Sakamoto, Norman Lacayo, Rachana Vinay Patil, Rhonda Perriman, Alma-Martina Cepika, Yunying Lucy Liu, Alex Kuo, Paul J. Utz, Purvesh Khatri, Alice Bertaina
Publikováno v:
Cancers, Vol 15, Iss 21, p 5204 (2023)
Juvenile myelomonocytic leukemia (JMML) is a deadly pediatric leukemia driven by RAS pathway mutations, of which >35% are gain-of-function in PTPN11. Although DNA hypermethylation portends severe clinical phenotypes, the landscape of histone modifica
Externí odkaz:
https://doaj.org/article/29ab817bcb0747f09e66a9e50ad71c86
Autor:
Ananthakrishnan Ganesan, Denis Dermadi, Laurynas Kalesinskas, Michele Donato, Rosalie Sowers, Paul J. Utz, Purvesh Khatri
Publikováno v:
iScience, Vol 26, Iss 1, Pp 105756- (2023)
Summary: Current technologies do not allow predicting interactions between histone post-translational modifications (HPTMs) at a system-level. We describe a computational framework, imputation-followed-by-inference, to predict directed association be
Externí odkaz:
https://doaj.org/article/9973f3cc1bd84b22a1d0bb6e7b996840
Autor:
Sarah Esther Chang, Allan Feng, Wenzhao Meng, Sokratis A. Apostolidis, Elisabeth Mack, Maja Artandi, Linda Barman, Kate Bennett, Saborni Chakraborty, Iris Chang, Peggie Cheung, Sharon Chinthrajah, Shaurya Dhingra, Evan Do, Amanda Finck, Andrew Gaano, Reinhard Geßner, Heather M. Giannini, Joyce Gonzalez, Sarah Greib, Margrit Gündisch, Alex Ren Hsu, Alex Kuo, Monali Manohar, Rong Mao, Indira Neeli, Andreas Neubauer, Oluwatosin Oniyide, Abigail E. Powell, Rajan Puri, Harald Renz, Jeffrey Schapiro, Payton A. Weidenbacher, Richard Wittman, Neera Ahuja, Ho-Ryun Chung, Prasanna Jagannathan, Judith A. James, Peter S. Kim, Nuala J. Meyer, Kari C. Nadeau, Marko Radic, William H. Robinson, Upinder Singh, Taia T. Wang, E. John Wherry, Chrysanthi Skevaki, Eline T. Luning Prak, Paul J. Utz
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Infection with SARS-CoV2 and the development of Coronavirus disease 2019 (COVID-19) has been linked to induction of autoimmunity and autoantibody production. Here the authors characterise the new-onset IgG autoantibody response in hospitalised patien
Externí odkaz:
https://doaj.org/article/66cae071533b4d708afeb170397e48a7
Autor:
Gloria Yiu, Tue Kruse Rasmussen, Brandon L. Tsai, Vivian K. Diep, David J. Haddon, Jennifer Tsoi, Gopika D. Miller, Begoña Comin-Anduix, Bent Deleuran, Gay M. Crooks, Paul J. Utz
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The establishment of an “interferon (IFN) signature” to subset SLE patients on disease severity has led to therapeutics targeting IFNα. Here, we investigate IFN signaling in SLE using multiplexed protein arrays and single cell cytometry by time
Externí odkaz:
https://doaj.org/article/9c4d59dbaa9c4bd5907b224d9ec6e824
Autor:
Léa Simoni, Jessy Presumey, Cees E. van der Poel, Carlos Castrillon, Sarah E. Chang, Paul J. Utz, Michael C. Carroll
Publikováno v:
Cell Reports, Vol 33, Iss 5, Pp 108330- (2020)
Summary: Systemic lupus erythematosus (SLE) is a severe autoimmune disease mediated by pathogenic autoantibodies. While complement protein C4 is associated with SLE, its isoforms (C4A and C4B) are not equal in their impact. Despite being 99% homologo
Externí odkaz:
https://doaj.org/article/c48ff8f821164560853c32065663b406
Autor:
Erika Bongen, Haley Lucian, Avani Khatri, Gabriela K. Fragiadakis, Zachary B. Bjornson, Garry P. Nolan, Paul J. Utz, Purvesh Khatri
Publikováno v:
Cell Reports, Vol 29, Iss 7, Pp 1961-1973.e4 (2019)
Summary: Sex differences in autoimmunity and infection suggest that a better understanding of molecular sex differences will improve the diagnosis and treatment of immune-related disease. We identified 144 differentially expressed genes, referred to
Externí odkaz:
https://doaj.org/article/b7b7a181600547bfaedd4ede5623851c