Výsledky vyhledávání - "Paul J. Tadrous"

Akademický článek

Quantification of Crypt and Stem Cell Evolution in the Normal and Neoplastic Human Colon

Autor: Ann-Marie Baker, Biancastella Cereser, Samuel Melton, Alexander G. Fletcher, Manuel Rodriguez-Justo, Paul J. Tadrous, Adam Humphries, George Elia, Stuart A.C. McDonald, Nicholas A. Wright, Benjamin D. Simons, Marnix Jansen, Trevor A. Graham

Publikováno v: Cell Reports, Vol 8, Iss 4, Pp 940-947 (2014)

Human intestinal stem cell and crypt dynamics remain poorly characterized because transgenic lineage-tracing methods are impractical in humans. Here, we have circumvented this problem by quantitatively using somatic mtDNA mutations to trace clonal li

Externí odkaz: https://doaj.org/article/5803d8f2cc1e4ffd817fc85712de1e0b

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Quantification of crypt and stem cell evolution in the normal and neoplastic human colon

Publikováno v: Cell Reports, Vol 8, Iss 4, Pp 940-947 (2014)
Cell reports, 8(4), 940-947. Cell Press
Cell Reports

Summary Human intestinal stem cell and crypt dynamics remain poorly characterized because transgenic lineage-tracing methods are impractical in humans. Here, we have circumvented this problem by quantitatively using somatic mtDNA mutations to trace c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc6c726433cef96362b6e41ca7c554a6

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Analysis of clonal expansions through the normal and premalignant human breast epithelium reveals the presence of luminal stem cells

Autor: Biancastella, Cereser, Marnix, Jansen, Emily, Austin, George, Elia, Taneisha, McFarlane, Carolien Hm, van Deurzen, Anieta M, Sieuwerts, Maria G, Daidone, Paul J, Tadrous, Nicholas A, Wright, Louise, Jones, Stuart Ac, McDonald

Publikováno v: The Journal of Pathology

It is widely accepted that the cell of origin of breast cancer is the adult mammary epithelial stem cell; however, demonstrating the presence and location of tissue stem cells in the human breast has proved difficult. Furthermore, we do not know the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::69b377a5c8f2b586d50ab689a7acec62
https://pubmed.ncbi.nlm.nih.gov/28940516

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Spatial Compounding Algorithm for Speckle Reduction of Dynamic Focus OCT Images

Autor: Taran Tatla, Mohammad R. N. Avanaki, Ramona Cernat, Paul J. Tadrous, Adrian Gh. Podoleanu, S. Ali Hojjatoleslami

Publikováno v: IEEE Photonics Technology Letters

Optical coherence tomography is capable of imaging the microstructures within tissues. To preserve the transverse resolution at all imaging depths, we implement a dynamic focusing scheme. To improve the quality of images further, a simple speckle red

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19c25eb62893072588175479799cabab
https://doi.org/10.1109/lpt.2013.2266660

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Dual instrument for in vivo and ex vivo OCT imaging in an ENT department

Autor: Adrian Gh. Podoleanu, Paul J. Tadrous, Adrian Bradu, Jingyin Pang, Grigory V. Gelikonov, Valentin M. Gelikonov, Taran Tatla, George Dobre, Ramona Cernat

Publikováno v: Biomedical Optics Express

A dual instrument is assembled to investigate the usefulness of optical coherence tomography (OCT) imaging in an ear, nose and throat (ENT) department. Instrument 1 is dedicated to in vivo laryngeal investigation, based on an endoscope probe head ass

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b43349c5fc09baf9c7c38824d1aad732
http://europepmc.org/articles/PMC3521301

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Estimation of cell density to aid in assessment of percentage cells of a particular lineage or of cells expressing a specific antigen in bone marrow trephine biopsies

Autor: Saeed Alshieban, Paul J. Tadrous, Kikkeri N. Naresh

Publikováno v: Journal of Clinical Pathology. 66:155-159

The authors aimed to develop a tool to assess total cell numbers in a microscope's field of vision, which would provide the denominator for calculating the percentage of positive cells for a given antigen in bone marrow trephine biopsies (BMTBs) of v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeae055e778337c1a46a83f7e49825a4
https://doi.org/10.1136/jclinpath-2011-200126

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The human urothelium consists of multiple clonal units, each maintained by a stem cell

Autor: Sagrario Cañadillas-Lopez, Paul J. Tadrous, Axel Heidenreich, Ruth Knuechel, Richard Poulsom, Stuart McDonald, Trevor A. Graham, Nicholas A. Wright, Gerhard Jakse, Nadine T. Gaisa

Publikováno v: The Journal of Pathology. 225:163-171

Little is known about the clonal architecture of human urothelium. It is likely that urothelial stem cells reside within the basal epithelial layer, yet lineage tracing from a single stem cell as a means to show the presence of a urothelial stem cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7dd3cc16eb65b2ba9c7ab97f8b7f3be9
https://doi.org/10.1002/path.2945

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