Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Paul J. Sinnott"'
Autor:
Paul J. Sinnott, Arun Gupta
Publikováno v:
Human Immunology. 70:618-622
The use of highly sensitive solid-phase antibody detection assays, including x-MAP multiple bead-based technology (Luminex), has greatly enhanced our ability to accurately detect and define very low levels of HLA antibodies. These developments have l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51cc5fb87c9464ffe97d4582f27352c8
https://doi.org/10.1016/j.humimm.2009.04.020
https://doi.org/10.1016/j.humimm.2009.04.020
Autor:
Martin J. Raftery, Daniel J. McCloskey, Mohammad M. Yaqoob, Mira Varagunam, Edward Sharples, Paul J. Sinnott
Publikováno v:
Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis. 26:64-68
Background The correction of anemia by recombinant human erythropoietin (rHuEPO) improves quality of life and prolongs life in end-stage renal failure. rHuEPO requirements for an individual are determined by a range of factors, including iron deficie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9363063e51a8aef73122b19a938d6dd
https://doi.org/10.1177/089686080602600110
https://doi.org/10.1177/089686080602600110
Autor:
Hazel Finney, Daniel J. McCloskey, Mira Varagunam, Ray Trevitt, Martin Raftery, Edward Sharples, Paul J. Sinnott, Muhammad M. Yaqoob
Publikováno v:
American Journal of Kidney Diseases. 43:502-507
Chronic inflammation, the common pathway that leads to cardiovascular disease and chronic allograft nephropathy after transplantation, is prevalent in patients with end-stage renal failure. We set out to investigate the hypothesis that enhanced pretr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c22dbe90d6d3daf322d0691a932e9af8
https://doi.org/10.1053/j.ajkd.2003.11.011
https://doi.org/10.1053/j.ajkd.2003.11.011
Publikováno v:
Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis. 23:111-115
Objectives To study the effect of angiotensin-converting enzyme (ACE) polymorphisms II, ID, and DD on erythropoietin (EPO) requirement in patients on continuous ambulatory peritoneal dialysis (CAPD) therapy. Design Retrospective observational study.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a6e1a97fbf36ae32371962e01c0863b
https://doi.org/10.1177/089686080302300203
https://doi.org/10.1177/089686080302300203
Autor:
Vera Pravica, David Sankaran, Ian Roberts, Paul J. Sinnott, Ian V. Hutchinson, Argiris Asderakis, Robert W. G. Johnson, Phil Dyer
Publikováno v:
Transplantation. 71:674-678
BACKGROUND Our group has previously described five different size alleles of an interferon (IFN)-gamma microsatellite. Analyzing this polymorphism, this study correlated high IFN-gamma production with a 12 CA repeat allele (allele 2). Further, our gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cd5d98a8ccfd1f948d3ada57d725804
https://doi.org/10.1097/00007890-200103150-00018
https://doi.org/10.1097/00007890-200103150-00018
Autor:
Peter J. Whorwell, Wendy M. Gonsalkorale, A. Tagore, Raymond Mcmahon, Vera Pravica, Ian V. Hutchinson, Ali H. Hajeer, Paul J. Sinnott
Publikováno v:
Tissue Antigens. 54:386-390
Interleukin-10 (IL-10) is an anti-inflammatory cytokine. Its production in humans is under genetic control, and genotype defines high or low producers of this cytokine. This study addresses the hypothesis that idiopathic inflammatory bowel disease (I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77656b0a14f6b84bf167cc1cc2c879a2
https://doi.org/10.1034/j.1399-0039.1999.540408.x
https://doi.org/10.1034/j.1399-0039.1999.540408.x
Autor:
Shazad Ashraf, Paul J. Sinnott, Colin D. Short, P.A. Dyer, Argiris Asderakis, I.A.N.S.D. Roberts, David Sankaran, Ian V. Hutchinson
Publikováno v:
Kidney International. 56(1):281-288
Cytokine gene polymorphisms predict acute graft rejection following renal transplantation.BackgroundThe proinflammatory cytokine tumor necrosis factor-α (TNF-α) has been implicated in the pathogenesis of acute rejection, while animal models suggest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d749f3b27e0d26b9ebb66f100aab6fd
Autor:
Ali H Rahman, James A. Hutchinson, Colin S. Campbell, Philip S. Hasleton, Abdul K. Deiraniya, Nizar Yonan, A El-Gamel, Mohammed Awad, Ian V. Hutchinson, Paul J. Sinnott
Publikováno v:
The Journal of Heart and Lung Transplantation. 18:517-523
BACKGROUND: TGF-beta1 is a prosclerotic cytokine implicated in fibrotic processes. Fibrosis of the pulmonary parenchyma and airways is a frequent presentation in lung transplant recipients before and after transplantation. There are two genetic polym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e3553d61a375c7bcde5a80b3ac3809c
https://doi.org/10.1016/s1053-2498(98)00024-2
https://doi.org/10.1016/s1053-2498(98)00024-2
Publikováno v:
Transplant Immunology. 6:193-197
Polymorphic variants of cytokine genes are associated with acute and chronic transplant rejection. In this technical report, the methods currently used in our centre to genotype individuals for interferon-gamma, interleukin-10, transforming growth fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b28b37654a42343e3d6a41f0cf1d2a3
https://doi.org/10.1016/s0966-3274(98)80045-2
https://doi.org/10.1016/s0966-3274(98)80045-2
Autor:
Jiri Vencovsky, Mark Lazarus, Paul J. Sinnott, Ian V. Hutchinson, David M. Turner, William E R Ollier, Ali H. Hajeer, Rizgar A. Mageed
Publikováno v:
Scandinavian Journal of Rheumatology. 27:142-145
IL-10 is an anti-inflammatory cytokine which may modulate disease expression in RA. Three dimorphic polymorphisms within the IL-10 gene promoter have recently been identified and appear to influence regulation of its expression. The -1082*A allele ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ac045dee89cdd1c7b3025b6d8c169f1
https://doi.org/10.1080/030097498441029
https://doi.org/10.1080/030097498441029