Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Paul J. Shughrue"'
Autor:
Ronald Torres, Stephen J. Tam, Jose R. Tapia, Gene G. Kinney, Salmans Joshua Reginald, Wagner Zago, Nijjar Tarlochan S, Dale Schenk, Mark Renz, Paul J. Shughrue, Philip J. Dolan, Robin Barbour, Lauri Li
Publikováno v:
Amyloid
Amyloid light chain (AL) amyloidosis is characterized by misfolded light chain (LC) (amyloid) deposition in various peripheral organs, leading to progressive dysfunction and death. There are no regulatory agency–approved treatments for AL amyloidos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6216796df035cd44f7cc7943723fefd
https://doi.org/10.1080/13506129.2016.1205974
https://doi.org/10.1080/13506129.2016.1205974
Publikováno v:
Journal of Histotechnology. 33:161-164
Alzheimer's disease is a progressive neurodegenerative disorder and the most common form of dementia, affecting as many as 10% of people older than the age of 65. One pathological hallmark of the d...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e92238dc887470c4c83a6731bd227dec
https://doi.org/10.1179/his.2010.33.4.161
https://doi.org/10.1179/his.2010.33.4.161
Autor:
Robert W. Hepler, Stephanie Villarreal, Joseph G. Joyce, Paul J. Shughrue, Renee C. Gaspar, Nicole Bowles
Publikováno v:
Experimental Neurology. 223:394-400
Amyloid plaque deposition in the brain is a hallmark of Alzheimer's disease, but recent evidence indicates that the disease may be primarily caused by soluble amyloid-β (1-42) (Aβ) oligomers or Aβ-derived diffusible ligands (ADDLs). ADDLs induce c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad62b99ea5fdc1f32854645c2a1e48f9
https://doi.org/10.1016/j.expneurol.2009.09.001
https://doi.org/10.1016/j.expneurol.2009.09.001
Autor:
Hong Jin, Frank D. Sistare, Wendy J. Bailey, Douglas Thudium, Stephanie Villarreal, Josef S Ozer, Holly K Clouse, Amy G. Aslamkhan, Shu Shi, Ming Su, John Seng, Sean P. Troth, Daniel J. Holder, David J. Figueroa, Nagaraja Muniappa, Paul J. Shughrue, Yan Yu, David Gerhold
Publikováno v:
Nature Biotechnology. 28:470-477
Exposure of rats to kidney toxicants reduces levels of urinary trefoil factor 3 (TFF3) and increases levels of urinary albumin. Whereas urinary albumin outperforms either serum creatinine (SCr) or blood urea nitrogen (BUN) for detecting kidney tubule
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e14d647d5a1fb2ddf3cd2bade75ac31f
https://doi.org/10.1038/nbt.1624
https://doi.org/10.1038/nbt.1624
Autor:
Gene G. Kinney, Matthew A. Seager, Paul J. Shughrue, William J. Ray, David J. Stone, Marc Ferrer, Francesca Santini, Abigail Wolfe, Matthew Townsend, Xiaohua Douglas Zhang, Dave Ross, Wei-Qin Zhao, Robert Breese
Publikováno v:
Journal of Biological Chemistry. 285:7619-7632
Synaptic degeneration, including impairment of synaptic plasticity and loss of synapses, is an important feature of Alzheimer disease pathogenesis. Increasing evidence suggests that these degenerative synaptic changes are associated with an accumulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00c77bfd100dab31b551fcc77c75b5bc
https://doi.org/10.1074/jbc.m109.057182
https://doi.org/10.1074/jbc.m109.057182
Autor:
Paul Acton, Sara J. Fernandez, Gene G. Kinney, Diana Wu, William L. Klein, Mary P. Lambert, Elizabeth Chen-Dodson, Paul J. Shughrue, Eileen H. Bigio, Jasna Jerecic, Fernanda G. De Felice, Pauline T. Velasco, Pascale N. Lacor
Publikováno v:
Neurobiology of Aging. 29:1334-1347
Alzheimer's disease (AD) is characterized by presence of extracellular fibrillar A beta in amyloid plaques, intraneuronal neurofibrillary tangles consisting of aggregated hyperphosphorylated tau and elevated brain levels of soluble A beta oligomers (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb5d6b5988196b1df5a56d0a3bc164aa
https://doi.org/10.1016/j.neurobiolaging.2007.02.029
https://doi.org/10.1016/j.neurobiolaging.2007.02.029
Autor:
Szabolcs Szarka, Istvan Merchenthaler, Heather A. Bimonte-Nelson, Katalin Prokai-Tatrai, Paul J. Shughrue, Angela Brodie, Peter Koulen, Katie J. McLaughlin, Vien Nguyen, Puja Garg, Todd D. Gould, Joshua S. Talboom, Cheryl D. Conrad, Laszlo Prokai, Gauri Sabnis
Publikováno v:
Science Translational Medicine. 7
Many neurological and psychiatric maladies originate from the deprivation of the human brain from estrogens. However, current hormone therapies cannot be used safely to treat these conditions commonly associated with menopause because of detrimental
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4facb4d77ef2facfaee8ea7d3f89397f
https://doi.org/10.1126/scitranslmed.aab1290
https://doi.org/10.1126/scitranslmed.aab1290
Autor:
Istvan Merchenthaler, Paul J. Shughrue
Publikováno v:
Drug Development Research. 66:172-181
Estrogen has been demonstrated to protect against brain injury, neurodegeneration, and cognitive decline. Furthermore, estrogen seems to specifically protect cortical and hippocampal neurons from ischemic injury. Here, the neuroprotective affects of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1d90de2a17df67a793e4663522e95ca
https://doi.org/10.1002/ddr.20056
https://doi.org/10.1002/ddr.20056
Publikováno v:
Annals of the New York Academy of Sciences. 1007:89-100
Estrogen has been demonstrated to protect against brain injury, neurodegeneration, and cognitive decline. Furthermore, estrogen seems to specifically protect cortical and hippocampal neurons from ischemic injury. Here our data evaluating the neuropro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b375c51402b83115d350982c52a9eea
https://doi.org/10.1196/annals.1286.009
https://doi.org/10.1196/annals.1286.009
Publikováno v:
NeuroReport. 14:951-954
Disrupted in Schizophrenia-1 (DISC1) was identified as truncated by a balanced translocation segregating with schizophrenia and other major mental illness in a large Scottish family. As a step in evaluating the function of DISC1 and its potential rol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c9623cda3fc8264e9708fb50741b578
https://doi.org/10.1097/00001756-200305230-00009
https://doi.org/10.1097/00001756-200305230-00009