Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Paul J. Scotting"'
Publikováno v:
PLoS ONE, Vol 19, Iss 3 (2024)
Externí odkaz:
https://doaj.org/article/5f41db01abd74951b7211fe8e579a8b0
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract Studying medulloblastoma, the most common malignant paediatric brain tumour, requires simple yet realistic in vitro models. In this study, we optimised a robust, reliable, three-dimensional (3D) culture method for medulloblastoma able to rec
Externí odkaz:
https://doaj.org/article/dec0aec1260d4e558e9d5a48ad6acb43
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Scientific Reports
Scientific Reports
Studying medulloblastoma, the most common malignant paediatric brain tumour, requires simple yet realistic in vitro models. In this study, we optimised a robust, reliable, three-dimensional (3D) culture method for medulloblastoma able to recapitulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8f387708dff2f7224167116cd84eddc
https://doaj.org/article/dec0aec1260d4e558e9d5a48ad6acb43
https://doaj.org/article/dec0aec1260d4e558e9d5a48ad6acb43
Autor:
Yi-Chuan Cheng, Fu-Yu Hsieh, Ming-Chang Chiang, Paul J Scotting, Hung-Yu Shih, Sheng-Jia Lin, Hui-Lan Wu, Han-Ting Lee
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54262 (2013)
Akt1 is well known for its role in regulating cell proliferation, differentiation, and apoptosis and is implicated in tumors and several neurological disorders. However, the role of Akt1 in neural development has not been well defined. We have isolat
Externí odkaz:
https://doaj.org/article/ab9e1d9c33124f8b81ae9246eb40d3c8
Bone morphogenetic protein (Bmp) signalling plays a central role in the decision of ectoderm to adopt either neural or non-neural fates. The effects of this signalling are seen at mid-gastrulation in the activation of genes such as the Gata factors a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6180a4e443df5940d73155c9ed8697ec
https://doi.org/10.1387/ijdb.062204cd
https://doi.org/10.1387/ijdb.062204cd
Autor:
Benjamin Squibb, Janet Shipley, Dzul Azri Mohamed Noor, Martin Cusack, Tom Reader, Safiah Alhazmi, Paul J. Scotting, Claire Wallace, Denise Sheer, Jennie N. Jeyapalan, Christopher Tan, Jaime Hughes, Matthew Carr
Publikováno v:
NPJ Genomic Medicine
Silencing of genes by DNA methylation is a common phenomenon in many types of cancer. However, the genome-wide effect of DNA methylation on gene expression has been analysed in relatively few cancers. Germ cell tumours (GCTs) are a complex group of m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9022a38394cb0e836c1ffb60afe5df21
http://eprints.nottingham.ac.uk/32049/
http://eprints.nottingham.ac.uk/32049/
Autor:
Paul J. Scotting, Christopher Tan
Publikováno v:
The Journal of Pathology. 229:4-11
Germ cell tumours found in the brain (intracranial GCTs) are a very unusual class of tumour for two reasons. First, they include a very diverse range of histological subtypes classified together due to their proposed common cell of origin. Second, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a738987a0dafb2c068ff8dc3ee9ae98
https://doi.org/10.1002/path.4098
https://doi.org/10.1002/path.4098
Autor:
Li-Sung Hsu, Hui-Lan Wu, Chu-Li Tsao, Hung-Yu Shih, Chia-Jung Shen, Yi-Chuan Cheng, Sheng-Jia Lin, Paul J. Scotting, Fu-Yu Hsieh
Publikováno v:
Cellular and Molecular Life Sciences. 70:935-950
The schizophrenia susceptibility gene, Rgs4, is one of the most intensively studied regulators of G-protein signaling members, well known to be fundamental in regulating neurotransmission. However, little is known about its role in the developing ner
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e5d60bf897d68ce523722283206a48c
https://doi.org/10.1007/s00018-012-1178-z
https://doi.org/10.1007/s00018-012-1178-z
Autor:
Noemí Cambray, Valerie Wilson, Paul J. Scotting, Guillaume Blin, Frederick C. K. Wong, Anestis Tsakiridis, Ron Wilkie, Rodrigo Osorno, Constantinos Economou, Ian Chambers
Publikováno v:
Development; Vol 139
Scopus-Elsevier
Scopus-Elsevier
The transcription factors Nanog and Oct4 regulate pluripotency in the pre-implantation epiblast and in derivative embryonic stem cells. During post-implantation development, the precise timing and mechanism of the loss of pluripotency is unknown. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d64059aa9b6c65356fb4edddd57c377
Autor:
Appleby Va, Edward C. Schwalbe, Tan Cl, Dzul Azri Mohamed Noor, Matthew J. Murray, David Walker, James Nicholson, Jennie N. Jeyapalan, Shih-Han Lee, Paul J. Scotting, Steven C. Clifford, John-Paul Kilday, Nicholas Coleman, Roger D. Palmer
Publikováno v:
British Journal of Cancer
Background: Yolk sac tumours (YSTs) and germinomas are the two major pure histological subtypes of germ cell tumours. To date, the role of DNA methylation in the aetiology of this class of tumour has only been analysed in adult testicular forms and w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62d124bf767f53006a072f79079e53d3
https://doi.org/10.1038/bjc.2011.218
https://doi.org/10.1038/bjc.2011.218