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pro vyhledávání: '"Paul J. Lydon"'
Autor:
Charles-André Lemelin, Boris M. Seletsky, Kimberley K. Aalfs, Paul J. Lydon, Davis Heather, Yoshito Kishi, Kathleen A. Salvato, Bruce A. Littlefield, Lynda Tremblay, Murray J. Towle, Charles E. Chase, Yongchun Shen, Lori A. Singer, Melvin J. Yu, Wanjun Zheng, Bruce F. Wels, Monica Palme
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:5551-5554
Structurally simplified macrocyclic ketone analogues of halichondrin B were prepared by total synthesis and found to retain the potent cell growth inhibitory activity in vitro, stability in mouse serum, and in vivo efficacy of the natural product.