Zobrazeno 1 - 10 of 82 pro vyhledávání: '"Paul J. Leibson"'
1
PI3K Links NKG2D Signaling to a CrkL Pathway Involved in Natural Killer Cell Adhesion, Polarity, and Granule Secretion
Autor: Paul J. Leibson, Renee A. Schoon, Christopher J. Dick, Lucas P. Nacusi, Colin M. Segovis, Daniel D. Billadeau
Publikováno v: The Journal of Immunology. 182:6933-6942
The NK cell-activating receptor NKG2D plays a critical role in the destruction of malignant cells, but many of the cell-signaling mechanisms governing NKG2D-mediated cellular cytotoxicity are unknown. We have identified an NKG2D-mediated signaling pa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a784b3afcfc365f1cc513f9cf6b1a244
https://doi.org/10.4049/jimmunol.0803840
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2
TREM-2 Mediated Signaling Induces Antigen Uptake and Retention in Mature Myeloid Dendritic Cells
Autor: Laura N. Arneson, Moses Rodriguez, Sara J. Felts, Marco Colonna, Larry R. Pease, Charles L. Howe, Jadee L. Upshaw, Paul J. Leibson, Suresh Radhakrishnan
Publikováno v: The Journal of Immunology. 181:7863-7872
Myeloid dendritic cells (mDC) activated with a B7-DC-specific cross-linking IgM Ab (B7-DC XAb) take up and retain Ag and interact with T cell compartments to affect a number of biologic changes that together cause strong antitumor responses and block
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::91a410ec6acfcc4c03de42661563f3d2
https://doi.org/10.4049/jimmunol.181.11.7863
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3
Dynamin 2 Regulates Granule Exocytosis during NK Cell-Mediated Cytotoxicity
Autor: Colin M. Segovis, Renee A. Schoon, Paul J. Leibson, Daniel D. Billadeau, Christopher J. Dick, Timothy S. Gomez, Zhenkun Lou, Laura N. Arneson
Publikováno v: The Journal of Immunology. 181:6995-7001
NK cells are innate immune cells that can eliminate their targets through granule release. In this study, we describe a specialized role for the large GTPase Dynamin 2 (Dyn2) in the regulation of these secretory events leading to cell-mediated cytoto
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fdf2c45ebf5f6db297c78bbdb5e51f7e
https://doi.org/10.4049/jimmunol.181.10.6995
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4
Cutting Edge: Syntaxin 11 Regulates Lymphocyte-Mediated Secretion and Cytotoxicity
Autor: Laura N. Arneson, Colin M. Segovis, Renee A. Schoon, Paul J. Leibson, Adipong Brickshawana, Christopher J. Dick
Publikováno v: The Journal of Immunology. 179:3397-3401
Little is known about the regulatory roles of specific soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins in cytotoxic lymphocytes. Recent information suggests that mutations in the SNARE protein syntaxin 11 result
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec5c54eb6aed127d67a9762c0d61965e
https://doi.org/10.4049/jimmunol.179.6.3397
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5
Differential Regulation of Human NK Cell-Mediated Cytotoxicity by the Tyrosine Kinase Itk
Autor: Laura N. Arneson, Renee A. Schoon, Paul J. Leibson, Christopher J. Dick, Dianne Khurana
Publikováno v: The Journal of Immunology. 178:3575-3582
NK cells are effector lymphocytes that can recognize and eliminate virally infected and transformed cells. NK cells express distinct activating receptors, including an ITAM-containing FcR complex that recognizes Ab-coated targets, and the DNAX-activa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05e08781fe2040b292467b0d84b52197
https://doi.org/10.4049/jimmunol.178.6.3575
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6
Formins Regulate the Actin-Related Protein 2/3 Complex-Independent Polarization of the Centrosome to the Immunological Synapse
Autor: Karan R. Kumar, Timothy S. Gomez, Daniel D. Billadeau, Rebecca Vasconcellos Botelho de Medeiros, Yoji Shimizu, Paul J. Leibson
Publikováno v: Immunity. 26:177-190
SummaryT cell receptor (TCR)-mediated cytoskeletal reorganization is considered to be actin-related protein (Arp) 2/3 complex dependent. We therefore examined the requirement for Arp2/3- and formin-dependent F-actin nucleation during T cell activatio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcef7ec8e1b8a72cfd3d58af475b8d8e
https://doi.org/10.1016/j.immuni.2007.01.008
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8
Tumor Necrosis Factor and Lymphotoxin Secretion by Human Natural Killer Cells Leads to Antiviral Cytotoxicity
Autor: N Kenmotsu, Paul J. Leibson, Carlos V. Paya, Renee A. Schoon
NK cells mediate their cytotoxicity against tumor cells through abroad array of cytotoxic and cytostatic proteins. We investigated whether specific proteins could also be identified that contributed to NK cell-mediated antiviral immunity. Human CD16+
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::61884b409b7b4b09e74891bf38e81862
https://doi.org/10.1159/000416306
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10
Stimulatory Killer Ig-Like Receptors Modulate T Cell Activation through DAP12-Dependent and DAP12-Independent Mechanisms
Autor: Melissa R. Snyder, Takako Nakajima, Jörg J. Goronzy, Cornelia M. Weyand, Paul J. Leibson
Publikováno v: The Journal of Immunology. 173:3725-3731
Stimulatory killer Ig-like receptors (KIRs) are expressed by various lymphocytes, including NK cells and subsets of T cells. In NK cells, KIRs associate with the adapter molecule KARAP/DAP12, which confers the ability to function as an independent ac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::054981049aa2ecce318a66466a955404
https://doi.org/10.4049/jimmunol.173.6.3725
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