Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Paul J. Kostyniak"'
Autor:
Matthew R. Bonner, Linda S. Birnbaum, James R. Olson, Paul J. Kostyniak, Xuefeng Ren, Jie Wang, Samantha L. VanEtten
Publikováno v:
Toxicology and applied pharmacology. 408
Telomere length (TL) can be affected by various factors, including age and oxidative stress. Changes in TL have been associated with chronic disease, including a higher risk for several types of cancer. Environmental exposure of humans to PCBs and di
Autor:
Darrell L. Ellsworth, Craig D. Shriver, Nicholas S. Costantino, Paul J. Kostyniak, Rachel E. Ellsworth, Lai-Har Chi
Publikováno v:
Environmental Toxicology. 33:876-884
Agricultural pesticides are abundant environmental contaminants worldwide, prompting interest in studying their possible detrimental health effects. We examined organochlorine residues by quadrant (n = 245) in breast adipose tissues from 51 women wit
Autor:
Jie Wang, Xuefeng Ren, Samantha L. VanEtten, Paul J. Kostyniak, Linda S. Birnbaum, Matthew R. Bonner, James R. Olson
Publikováno v:
Toxicology
Mitochondria are intracellular organelles responsible for biological oxidation and energy production. These organelles are susceptible to damage from oxidative stress and compensate for damage by increasing the number of copies of their own genome, m
Autor:
Craig D. Shriver, Paul J. Kostyniak, Rachel E. Ellsworth, Darrell L. Ellsworth, Brenda Deyarmin, Lai-Har Chi, Kimberly A. Mamula, Nicholas S. Costantino
Publikováno v:
Environmental Research. 138:291-297
Many environmental chemicals accumulate in human tissues and may contribute to cancer risk. Polychlorinated biphenyls (PCBs) are associated with adverse health effects, but relationships between PCB exposure and breast cancer are unclear. In this stu
Autor:
Lai Har Chi, Paul J. Kostyniak, Helen J.K. Sable, Susan L. Schantz, Supida Monaikul, Emily Poon
Publikováno v:
Neurotoxicology and Teratology. 38:6-12
PCBs have long been known to affect dopamine (DA) function in the brain. The current study used an amphetamine behavioral sensitization paradigm in rats developmentally exposed to PCBs. Long–Evans rats were given perinatal exposure to 0, 3, or 6 mg
Autor:
Courtney D. Lynch, Paul J. Kostyniak, Bridget M. McGuinness, Leila W. Jackson, Germaine M. Buck Louis
Publikováno v:
Reproductive Toxicology. 34:451-456
a b s t r a c t We examined the association between prenatal and postnatal exposure to PCBs and development at age 24 months as measured by the Bayley Scales of Infant Development II. 44 (85%) of 52 children had infor- mation available. When prenatal
Autor:
Rebecca J. Schmidt, Rima Woods, Isaac N. Pessah, Janine M. LaSalle, Lai Har Chi, Michelle M. Mitchell, Paul J. Kostyniak
Publikováno v:
Environmental and Molecular Mutagenesis. 53:589-598
Persistent organic pollutants (POPs), including polychlorinated biphenyls (PCBs) and polybrominated diphenylethers (PBDEs) that bioaccumulate in lipid-rich tissues are of concern as developmental neurotoxicants. Epigenetic mechanisms such as DNA meth
Autor:
Dag H. Yasui, Robert F. Berman, Lai Har Chi, Isaac N. Pessah, Mari S. Golub, Joanne K. Suarez, Janine M. LaSalle, Rima Woods, Roxanne O. Vallero, Tram Anh Ta, Paul J. Kostyniak
Publikováno v:
Human Molecular Genetics. 21:2399-2411
The widespread use of persistent organic polybrominated diphenyl ethers (PBDEs) as commercial flame retardants has raised concern about potential long-lived effects on human health. Epigenetic mechanisms, such as DNA methylation, are responsive to en
Autor:
Lisa A. Opanashuk, Deborah A. Cory-Slechta, Richard Fitzpatrick, Sarah A. Notter, Mona Thiruchelvam, Donna W. Lee, Daniel P. Dever, Paul J. Kostyniak
Publikováno v:
Toxicological Sciences. 125:496-508
Recent epidemiologic studies have demonstrated a link between organochlorine and pesticide exposure to an enhanced risk for neurodegenerative disorders such as Parkinson’s disease (PD). A common biological phenomenon underlying cell injury associat
Publikováno v:
Journal of Environmental Protection. :683-691
Polychlorinated biphenyls (PCBs) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) are suspected re-productive toxicants. We assessed serum concentration of 76 PCB congeners, DDE, and risk of human chorionic gonadotropin confirmed pregnancy loss