Zobrazeno 1 - 10
of 159
pro vyhledávání: '"Paul J. Kenny"'
Autor:
Kevin M. Braunscheidel, George Voren, Christie D. Fowler, Qun Lu, Alexander Kuryatov, Michael D. Cameron, Ines Ibañez-Tallon, Jon M. Lindstrom, Theodore M. Kamenecka, Paul J. Kenny
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
BackgroundMost smokers attempting to quit will quickly relapse to tobacco use even when treated with the most efficacious smoking cessation agents currently available. This highlights the need to develop effective new smoking cessation medications. E
Externí odkaz:
https://doaj.org/article/13755185d072421ba960bb627e47c5e1
Autor:
Dana Lengel, Paul J. Kenny
Publikováno v:
Addiction Neuroscience, Vol 7, Iss , Pp 100103- (2023)
Diseases associated with nicotine dependence in the form of habitual tobacco use are a major cause of premature death in the United States. The majority of tobacco smokers will relapse within the first month of attempted abstinence. Smoking cessation
Externí odkaz:
https://doaj.org/article/fc3e7b0d15ec4c14bcd67c1d3552349b
Publikováno v:
Pharmacological Research, Vol 194, Iss , Pp 106860- (2023)
Cigarette smoking has long been recognized as a risk factor for type 2 diabetes (T2D), although the precise causal mechanisms underlying this relationship remain poorly understood. Recent evidence suggests that nicotine, the primary reinforcing compo
Externí odkaz:
https://doaj.org/article/b44455980a424d9998e18c2c5b260fca
Autor:
Alexander C. W. Smith, Sietse Jonkman, Alexandra G. Difeliceantonio, Richard M. O’Connor, Soham Ghoshal, Michael F. Romano, Barry J. Everitt, Paul J. Kenny
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
New instrumental learning occurs through an unexpected delivery of a rewarding stimulus or the withdrawal of a punishing stimulus. The authors show that D1 receptor-expressing medium spiny neurons (MSNs) in the anterior dorsolateral striatum encode n
Externí odkaz:
https://doaj.org/article/268c60f143c3450aace33229b83ad544
Autor:
Teagan R. Wall, Brandon J. Henderson, George Voren, Charles R. Wageman, Purnima Deshpande, Bruce N. Cohen, Sharon R. Grady, Michael J. Marks, Daniel Yohannes, Paul J. Kenny, Merouane Bencherif, Henry A. Lester
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
(E)-5-(Pyrimidin-5-yl)-1,2,3,4,7,8-hexahydroazocine (TC299423) is a novel agonist for nicotinic acetylcholine receptors (nAChRs). We examined its efficacy, affinity, and potency for α6β2∗ (α6β2-containing), α4β2∗, and α3β4∗ nAChRs, usin
Externí odkaz:
https://doaj.org/article/fe16dc1017fe4cafa3021cac90dfb168
Autor:
Imen Becetti, Esther L Bwenyi, Ivan E de Araujo, Jamy Ard, John F Cryan, Ismaa Sadaf Farooqi, Carrie R Ferrario, Marci E Gluck, Laura M Holsen, Paul J Kenny, Elizabeth A Lawson, Bradford B Lowell, Ellen A Schur, Takara L Stanley, Ali Tavakkoli, Steven K Grinspoon, Vibha Singhal
Publikováno v:
The American Journal of Clinical Nutrition
Obesity is increasing at an alarming rate. The effectiveness of currently available strategies for the treatment of obesity (including pharmacologic, surgical, and behavioral interventions) is limited. Understanding the neurobiology of appetite and t
Autor:
Clementine Fillinger, Alessia Manganaro, George Voren, Tiffany Zou, Dani Dumitriu, Yael S Grossman, William G.M. Janssen, Rachel Waldman, Paul J. Kenny
Publikováno v:
Neuropsychopharmacology
Stressful life events are ubiquitous and well-known to negatively impact mental health. However, in both humans and animal models, there is large individual variability in how individuals respond to stress, with some but not all experiencing long-ter
Autor:
Purva Bali, Paul J. Kenny
Publikováno v:
Neuron
Neuronal alternative splicing is a key gene regulatory mechanism in brain. Yet the spliceosome machinery is insufficient to fully specify splicing complexity. In considering the role of the epigenome in activity-dependent alternative splicing, we and
Autor:
Rajita Sinha, Paul J. Kenny, Emeran A. Mayer, Michael L. Oshinsky, Hugo D. Critchley, Bruno Bonaz, Richard D. Lane
Publikováno v:
Trends in Neurosciences
Trends in Neurosciences, Elsevier, 2021, 44, pp.39-51. ⟨10.1016/j.tins.2020.09.009⟩
Trends in Neurosciences, 2021, 44, pp.39-51. ⟨10.1016/j.tins.2020.09.009⟩
Trends in Neurosciences, Elsevier, 2021, 44, pp.39-51. ⟨10.1016/j.tins.2020.09.009⟩
Trends in Neurosciences, 2021, 44, pp.39-51. ⟨10.1016/j.tins.2020.09.009⟩
International audience; Interoception, the sense of the body's internal physiological state, underpins homeostatic reflexes, motivational states, and sensations contributing to emotional experiences. The continuous nature of interoceptive processing,
Autor:
Christie D. Fowler, Karim S. Elayouby, Paul J. Kenny, Masago Ishikawa, Qun Lu, Angeline J. Dukes, Alexander C.W. Smith
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience, vol 41, iss 8
J Neurosci
J Neurosci
Allelic variation inCHRNA3, the gene encoding the α3 nicotinic acetylcholine receptor (nAChR) subunit, increases vulnerability to tobacco dependence and smoking-related diseases, but little is known about the role for α3-containing (α3*) nAChRs in