Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Paul J. Isackson"'
Autor:
Wilson Chen, Heather M Ochs-Balcom, Changxing Ma, Paul J Isackson, Georgirene D Vladutiu, Jasmine A Luzum
Publikováno v:
Future Cardiol
Aim: To determine the association of coenzyme Q10 (CoQ10) use with the resolution of statin-associated muscle symptoms (SAMS). Patients & methods: Retrospective analysis of a large, multicenter survey study of SAMS (total n = 511; n = 64 CoQ10 users)
Autor:
Daniel A. Perry, Georgirene D. Vladutiu, Chang-Xing Ma, Derek W. Linskey, Paul J. Isackson, Heather M. Ochs-Balcom, Joseph D. English, Jasmine A. Luzum
Publikováno v:
Pharmacogenet Genomics
The most common adverse drug reaction from statins are statin-associated muscle symptoms (SAMS), characterized by myopathy (weakness), myalgia (muscle pain), and commonly elevation in serum creatine kinase. All statins are substrates of the organic a
Publikováno v:
Current Rheumatology Reports. 22
This report describes the clinical manifestations of 35 patients sent to a University Immunology clinic with a diagnosis of fatigue and exercise intolerance who were identified to have low carnitine palmitoyl transferase activity on muscle biopsies.
Publikováno v:
Growth Regulation and Carcinogenesis ISBN: 9781351072311
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8cb37e4ab03d17f96a06907aab75405
https://doi.org/10.1201/9781351072311-19
https://doi.org/10.1201/9781351072311-19
Autor:
Smitha R. James, Jonathan E. Bard, Paul J. Isackson, Jianxin Wang, Tae Keun Lee, Adrian Levesque, Paul Spurgeon, Norma J. Nowak, Mohammad Zia, Georgirene D. Vladutiu
Aim: To examine the genetic differences between subjects with statin-associated muscle symptoms and statin-tolerant controls. Materials & methods: Next-generation sequencing was used to characterize the exomes of 76 subjects with severe statin-associ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bf4b22dcf0fcb75125fba11d20359a5
https://europepmc.org/articles/PMC6563124/
https://europepmc.org/articles/PMC6563124/
Publikováno v:
Progress in Nonhistone Protein Research ISBN: 9781351076050
Progress in Nonhistone Protein Research
Progress in Nonhistone Protein Research
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53fc5f0296608a22e73a1a56e2c19877
https://doi.org/10.1201/9781351076050-2
https://doi.org/10.1201/9781351076050-2
Autor:
Mark A. Tarnopolsky, Paul J. Isackson, Robert L. Wortmann, Georgirene D. Vladutiu, Chang-Xing Ma, Joseph P Kitzmiller, Lisa Christopher-Stine, Jasmine A. Luzum, Heather M. Ochs-Balcom, Ly Minh Nguyen, Michael H. Weisman, Wendy Peltier
Publikováno v:
Musclenerve. 59(5)
Introduction Statins reduce cardiovascular disease risk and are generally well tolerated, yet up to 0.5% of statin-treated patients develop incapacitating muscle symptoms including rhabdomyolysis. Our objective was to identify clinical factors relate
Autor:
Anees M. Dauki, Joseph P Kitzmiller, Marisa W. Medina, Eduard B. Mikulik, Heather M. Ochs-Balcom, Paul J. Isackson, Chang-Xing Ma, Jasmine A. Luzum, Georgirene D. Vladutiu
Publikováno v:
Cell Metabolism. 21(4):622-627
Summary Statin-induced myopathy (SIM) is the most common reason for discontinuation of statin therapy. A polymorphism affecting the gene encoding glycine amidinotransferase ( GATM rs9806699 G > A) was previously associated with reduced risk for SIM.
Publikováno v:
Muscle & Nerve. 47:224-229
Introduction: Twenty-six patients with clinical symptoms of adult onset carnitine palmitoyltransferase II (CPTII) deficiency were examined. All patients had skeletal muscle CPTII enzyme activity levels indicative of heterozygosity for CPT2 mutations,
Autor:
Wendy Peltier, Robert L. Wortmann, Steven K. Baker, Alexandru Barboi, Naganand Sripathi, Mark A. Tarnopolsky, J. Kilpatrick, Alan N. Baer, Heather M. Ochs-Balcom, Beth L. Cobb, Zachary Simmons, John B. Harley, Georgirene D. Vladutiu, Edward J. Fine, Stephen A. Smith, Paul J. Isackson, Jon D. Wilson, Kenneth M. Kaufman, Chang-Xing Ma
Publikováno v:
Muscle & Nerve. 44:531-538
Introduction: Of the nearly 38 million people in the USA who receive statin therapy, 0.1-0.5% experience severe or life-threatening myopathic side effects. Methods: We performed a genome-wide association study (GWAS) in a group of patients with sever