Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Paul J. Hippenmeyer"'
Publikováno v:
Antiviral Research. 55:291-306
Herpesviruses encode a protease that is essential for virus replication. The protease undergoes cleavage to a processed form during capsid maturation. A recombinant 75 kDa form of the protease from human cytomegalovirus was purified and compared with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16d95ac86a66d67d8863cf43372fa6d3
https://doi.org/10.1016/s0166-3542(02)00051-7
https://doi.org/10.1016/s0166-3542(02)00051-7
Autor:
Daniel L. Flynn, Vickie M. Dilworth, Paul J. Hippenmeyer, Norman Anthony Abood, Barry C. Holwerda, Arthur J. Wittwer, Lori A. Schretzman, K. A. Houseman
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:2105-2108
A series of 2-amino substituted benzoxazinones were prepared that potently inhibit human cytomegalovirus protease in vitro. Selected compounds demonstrate antiviral activity in cell culture, selectivity relative to chymotrypsin and elastase and stabi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::812e0c7fe304fb8183b182d6900429f1
https://doi.org/10.1016/s0960-894x(97)00368-5
https://doi.org/10.1016/s0960-894x(97)00368-5
Publikováno v:
Antiviral Research. 32:35-42
RC256, the recombinant human cytomegalovirus (HCMV) which expresses beta-galactosidase, was used as a tool for rapid screening of compounds for antiviral activity. The effective concentration of antiviral compound needed to inhibit RC256 was identica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0324e6380b462867f392e4291703a95c
https://doi.org/10.1016/0166-3542(95)00976-0
https://doi.org/10.1016/0166-3542(95)00976-0
Autor:
Lyle E. Pegg, Paul J. Hippenmeyer
Publikováno v:
Current Opinion in Biotechnology. 6:548-552
The herpesvirus VP16 transactivator has become a useful tool for facilitating the production of recombinant proteins in cultured mammalian cells. Not only does it afford the rapid isolation of stable high-level producer cell lines, but also VP16-expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7900cdb1698923930891c2090fa25ec
https://doi.org/10.1016/0958-1669(95)80091-3
https://doi.org/10.1016/0958-1669(95)80091-3
Autor:
Vickie M. Dilworth, Barry C. Holwerda, Daniel L. Flynn, Norman Anthony Abood, K. A. Houseman, Arthur J. Wittwer, Lori A. Schretzman, Paul J. Hippenmeyer
Publikováno v:
ChemInform. 28
A series of 2-amino substituted benzoxazinones were prepared that potently inhibit human cytomegalovirus protease in vitro. Selected compounds demonstrate antiviral activity in cell culture, selectivity relative to chymotrypsin and elastase and stabi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e538e40bb28b10d6456ffdcfc4b06aa9
https://doi.org/10.1002/chin.199750160
https://doi.org/10.1002/chin.199750160
Autor:
Tze-Chein Wun, Kuniko K Kretzmer, Mark O Palmier, Kathleen C Day, Margaret D Huang, Dean J Welsch, Charles Lewis, Richard A Wolfe, James F Zobel, Gary W Lange, Ronald B Frazier, Gary S Bild, Michelle A Peel, Robert E Shell, Nancy A Horn, Kurt D Junger, Barbara A Foy, Mark E Gustafson, Richard M Leimgruber, William F Novotny, George J Broze, Yvonne E Pyla, Paul J Hippenmeyer, Thomas G Warren
Publikováno v:
Thrombosis and Haemostasis. 68:054-059
SummaryRecombinant tissue factor pathway inhibitor (rTFPI) has been expressed in four mammalian expression systems using human SK hepatoma, mouse C127, baby hamster kidney (BHK), and Chinese hamster ovary (CHO) cells as hosts. On sodium dodecyl sulfa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d63389b2c57bc358d4345af1819cf2f
https://doi.org/10.1055/s-0038-1656317
https://doi.org/10.1055/s-0038-1656317
Autor:
Paul J. Hippenmeyer, Gwen G. Krivi
Publikováno v:
Poultry Science. 70:982-992
Avian retrovirus vectors, with potential for use in avian transformation, were constructed to evaluate the relative efficiency of promoters placed internal to the viral long terminal repeats (LTR). The vectors are replication-defective reticuloendoth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9aa4055b198d004fa69ff37d8b09d4b
https://doi.org/10.3382/ps.0700982
https://doi.org/10.3382/ps.0700982
Autor:
Barbara A. Schweitzer, Paul J. Hippenmeyer, Monique Heitmeier, James K. Bashkin, Megh Singh, Kathleen S. Crowley, Hossein Shabany, Barry L. Burnette, Dennis P. Phillion, Scott S. Woodard
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(9)
The intracellular distribution of fluorescent-labeled polyamides was examined in live cells. We showed that BODIPY-labeled polyamides accumulate in acidic vesicles, mainly lysosomes, in the cytoplasm of HCT116 colon cancer cells and human rheumatoid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fd766d473bbc3791fda85f8633340ab
https://pubmed.ncbi.nlm.nih.gov/12699756
https://pubmed.ncbi.nlm.nih.gov/12699756
Publikováno v:
Antiviral research. 55(1)
Many viruses and bacterial pathogens are capable of exploiting host cell surface integrins during their replication cycles. The ligands for many integrins contain an arginine-glycine-aspartic acid (RGD) amino acid sequence that is essential for prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf2168773580e9ce66e1542a8beb8fc6
https://pubmed.ncbi.nlm.nih.gov/12076761
https://pubmed.ncbi.nlm.nih.gov/12076761
Publikováno v:
Bio/technology (Nature Publishing Company). 11(9)
We have engineered mammalian cell lines to produce high levels of heterologous proteins by constructing a cell line that expresses the herpesvirus transactivator, VP16. Subsequent stable transfection with a gene of interest under control of a herpesv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9e1d44b8a04c569fc13ebc24aca85f2
https://pubmed.ncbi.nlm.nih.gov/7764072
https://pubmed.ncbi.nlm.nih.gov/7764072