Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Paul J. Guyett"'
Autor:
Carlos E. Sanz-Rodríguez, Benjamin Hoffman, Paul J. Guyett, Andrei Purmal, Baljinder Singh, Michael P. Pollastri, Kojo Mensa-Wilmot
Publikováno v:
Mol Pharmacol
CBL0137 is a lead drug for human African trypanosomiasis, caused by Trypanosoma brucei. Herein, we use a four-step strategy to 1) identify physiologic targets and 2) determine modes of molecular action of CBL0137 in the trypanosome. First, we identif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c23305b40f90484af006600943a6ecd4
https://europepmc.org/articles/PMC9341264/
https://europepmc.org/articles/PMC9341264/
Autor:
Gautam Patel, Jessey Erath, Ana Rodriguez, Jennifer L. Woodring, Norma Roncal, Richard J. Sciotti, Baljinder Singh, Michael P. Pollastri, Erica Penn, Emanuele Amata, Amrita Sharma, Justin Wiedeman, Susan E. Leed, Paul J. Guyett, Ranjan Behera, Kojo Mensa-Wilmot
Publikováno v:
ACS Medicinal Chemistry Letters. 9:996-1001
[Image: see text] Discovery of new chemotherapeutic lead agents can be accelerated by optimizing chemotypes proven to be effective in other diseases to act against parasites. One such medicinal chemistry campaign has focused on optimizing the anilino
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::423f29f906761c8401afba1b8b2fd9d8
https://doi.org/10.1021/acsmedchemlett.8b00245
https://doi.org/10.1021/acsmedchemlett.8b00245
Publikováno v:
ACS Infectious Diseases. 2:518-528
Human parasite Trypanosoma brucei proliferates in the blood of its host, where it takes up iron via receptor-mediated endocytosis of transferrin (Tf). Mechanisms of Tf endocytosis in the trypanosome are not fully understood. Small molecule lapatinib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe86c2ceee111916d8e13177f933b153
https://doi.org/10.1021/acsinfecdis.6b00077
https://doi.org/10.1021/acsinfecdis.6b00077
Publikováno v:
Antimicrobial Agents and Chemotherapy. 61
Human African trypanosomiasis is a neglected tropical disease caused by the protozoan parasite Trypanosoma brucei . Lapatinib, a human epidermal growth factor receptor (EGFR) inhibitor, can cure 25% of trypanosome-infected mice, although the parasite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d9e961f386f3fffcd89d721574b115b
https://doi.org/10.1128/aac.01865-16
https://doi.org/10.1128/aac.01865-16
Publikováno v:
Genetic Engineering & Biotechnology News. 38:14-15
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbf4e32e46c947d47cea2194773fe630
https://doi.org/10.1089/gen.38.20.08
https://doi.org/10.1089/gen.38.20.08
Autor:
Caitlin E. Karver, Paul J. Guyett, Gautam Patel, Catherine Sullenberger, Norma Roncal, Kojo Mensa-Wilmot, Ranjan Behera, Michael P. Pollastri, Peter M. Edwards
Publikováno v:
Journal of Medicinal Chemistry. 56:3820-3832
Human African trypanosomiasis (HAT) is a neglected tropical disease caused by the protozoan parasite Trypanosoma brucei . Because drugs in use against HAT are toxic and require intravenous dosing, new drugs are needed. Initiating lead discovery campa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1270a7a629b80bc5d4468b14affdbf03
https://doi.org/10.1021/jm400349k
https://doi.org/10.1021/jm400349k
Autor:
Stephen R. Gomez, Shuangluo Xia, Zachary T. Swinney, Chakk Ramesha, David C. Swinney, Brad A. Haubrich, Paul J. Guyett, Kojo Mensa-Wilmot
Publikováno v:
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 10, Iss 3, p e0004506 (2016)
PLoS Neglected Tropical Diseases, Vol 10, Iss 3, p e0004506 (2016)
Background New therapeutics are needed for neglected tropical diseases including Human African trypanosomiasis (HAT), a progressive and fatal disease caused by the protozoan parasites Trypanosoma brucei gambiense and T. b. rhodesiense. There is a nee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af79ffc53016b87efb513151d90f19ba
http://europepmc.org/articles/PMC4778863
http://europepmc.org/articles/PMC4778863
Autor:
Paul J. Guyett, Lisa M. Gloss
Publikováno v:
Journal of molecular biology. 415(3)
The H2A-H2B histone heterodimer folds via monomeric and dimeric kinetic intermediates. Within ~5 ms, the H2A and H2B polypeptides associate in a nearly diffusion-limited reaction to form a dimeric ensemble, denoted I2 and I2*, the latter being a sub-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8662c47318e40f59e6aed2e4e97ab86
https://pubmed.ncbi.nlm.nih.gov/22137897
https://pubmed.ncbi.nlm.nih.gov/22137897
The conversion of UDP-alpha-d-glucuronic acid to UDP-alpha-d-xylose and UDP-alpha-d-apiose by a bifunctional potato enzyme UDP-apiose/UDP-xylose synthase was studied using real-time nuclear magnetic resonance (NMR) spectroscopy. UDP-alpha-d-glucuroni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c6e87a85d4e1d9f3c008350e6a7216d
https://europepmc.org/articles/PMC4000172/
https://europepmc.org/articles/PMC4000172/