Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Paul J. Godowski"'
Autor:
Paul J. Godowski, Tamas Oravecz, Deanna Grant, Brian Zambrowicz, Nico Ghilardi, Dennis S. Rice, Weilan Ye, Mark J. Solloway, Wei Yu Lin, Kathleen H. Holt, Jerry Tang, Gwenn M. Hansen, Derek E. Eberhart, Tracy Tang, Yun Li, Flavius Martin, William F. Forrest, Alejandro Abuin, Frederic J. de Sauvage, Andrew S. Peterson, Li Li, Leon Parker, Kenneth A. Platt
Publikováno v:
Nature Biotechnology. 28:749-755
Large collections of knockout organisms facilitate the elucidation of gene functions. Here we used retroviral insertion or homologous recombination to disrupt 472 genes encoding secreted and membrane proteins in mice, providing a resource for studyin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cfe471cbc46759bbb5beb9cfed6eab4
https://doi.org/10.1038/nbt.1644
https://doi.org/10.1038/nbt.1644
Autor:
T. Aita, Sachiko Akashi, Akira Okamoto, Hirofumi Makino, Mitsuhiro Iwahashi, Masahiro Yamamura, A. Ueno, Kensuke Miyake, Norio Ogawa, Paul J. Godowski
Publikováno v:
Arthritis & Rheumatism. 50:1457-1467
Objective CD16 (IgG Fcgamma receptor type IIIA [FcgammaRIIIA])-expressing CD14+ monocytes express high levels of Toll-like receptor 2 (TLR-2) and are able to efficiently produce proinflammatory cytokines such as tumor necrosis factor alpha (TNFalpha)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d3c380e4b71d08ae5765eeb87683ac4
https://doi.org/10.1002/art.20219
https://doi.org/10.1002/art.20219
Autor:
Robert L. Modlin, Paul J. Godowski, Tomas Ganz, Yan J. Zhang, Edith Porter, Qi Wu, Scott H. Randell, Karl Heinz Weismüller, Cheryl J. Hertz
Publikováno v:
The Journal of Immunology. 171:6820-6826
As pattern recognition receptors capable of eliciting responses to a diverse array of microbial products, Toll-like receptors (TLRs) participate in the activation of host defense mechanisms that protect against infectious pathogens. Given that epithe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c3aa475b3c40e376239a88d13f5c6b8
https://doi.org/10.4049/jimmunol.171.12.6820
https://doi.org/10.4049/jimmunol.171.12.6820
Autor:
Rochelle M. Jean-Jacques, Richard B. Sisson, Ofer Levy, Jennifer L. Christianson, Anne Nicholson-Weller, Paul J. Godowski, Michael R. Wessels, Kol A. Zarember, Hilde-Kari Guttormsen, Michael C. Carroll, Colette Cywes
Publikováno v:
Infection and Immunity. 71:6344-6353
Group B Streptococcus (Streptococcus agalactiae, or GBS) is a major cause of neonatal sepsis and meningitis leading to significant morbidity and mortality (39). GBS also infects pregnant and parturient women and is a growing cause of infections in no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c76e4d27f45a666ed3659d4e11af4e0
https://doi.org/10.1128/iai.71.11.6344-6353.2003
https://doi.org/10.1128/iai.71.11.6344-6353.2003
Publikováno v:
The Journal of Immunology. 167:1882-1885
Flagellin, the structural component of bacterial flagella, is secreted by pathogenic and commensal bacteria. Flagellin activates proinflammatory gene expression in intestinal epithelia. However, only flagellin that contacts basolateral epithelial sur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3896d6c1b34a7ac8d3c8a7bd764520db
https://doi.org/10.4049/jimmunol.167.4.1882
https://doi.org/10.4049/jimmunol.167.4.1882
Autor:
Nicole Teusch, Mausumee Guha, Lois Kline, Jean Paul Mira, Paul J. Godowski, Nigel Mackman, Laurence Arbibe, Richard J. Ulevitch, Ulla G. Knaus
Publikováno v:
Nature Immunology. 1:533-540
Mammalian Toll-like receptors (TLRs) are expressed on innate immune cells and respond to the membrane components of Gram-positive or Gram-negative bacteria. When activated, they convey signals to transcription factors that orchestrate the inflammator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea80ac285fc92de474b268fdf7c9aa52
https://doi.org/10.1038/82797
https://doi.org/10.1038/82797
Autor:
Sylvia M. Kiertscher, Sybille Thoma-Uszynski, Robert L. Modlin, Kensuke Miyake, Michael D. Roth, Maria Teresa Ochoa, Paul J. Godowski, Deborah A. Bouis, Michael V. Norgard
Publikováno v:
The Journal of Immunology. 165:3804-3810
Mammalian Toll-like receptors (TLRs) are required for cell activation by bacterial lipoproteins (bLP) and LPS. Stimulation of monocytes with bLP and LPS results in a TLR-dependent induction of immunomodulatory genes leading to the production of pro-i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ac3cec31401a50d6dcf5a7da8bd962d
https://doi.org/10.4049/jimmunol.165.7.3804
https://doi.org/10.4049/jimmunol.165.7.3804
Publikováno v:
The EMBO Journal. 19:3325-3336
The innate immune system uses Toll family receptors to signal for the presence of microbes and initiate host defense. Bacterial lipoproteins (BLPs), which are expressed by all bacteria, are potent activators of Toll-like receptor-2 (TLR2). Here we sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5db91fcaa552eb0eef2b8abc3e2189bb
https://doi.org/10.1093/emboj/19.13.3325
https://doi.org/10.1093/emboj/19.13.3325
Autor:
Scott E. Plevy, John T. Belisle, Ruey-Bing Yang, Paul J. Godowski, Daniel H. Libraty, Michael V. Norgard, Patrick J. Brennan, Joshua R. Bleharski, Michael Maitland, Barry R. Bloom, Stephen T. Smale, Robert L. Modlin, Hans Brightbill, Stephan R. Krutzik
Publikováno v:
Science. 285:732-736
The generation of cell-mediated immunity against many infectious pathogens involves the production of interleukin-12 (IL-12), a key signal of the innate immune system. Yet, for many pathogens, the molecules that induce IL-12 production by macrophages
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a962da63085e2c29a64f536b76fc0ba9
https://doi.org/10.1126/science.285.5428.732
https://doi.org/10.1126/science.285.5428.732
Publikováno v:
Structure. 6(11):1383-1393
Background: Hepatocyte growth factor (HGF) is a mitogen for hepatocytes and has also been implicated as an epithelial morphogen in tumor invasion. HGF activates its specific cellular receptor, c- met , through an aggregation mechanism potentiated by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b34763c0f45bdb771fccf5d04ac3c32b