Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Paul J. Gane"'
Autor:
Clare Mills, Sandra A. Hemkemeyer, Zerin Alimajstorovic, Chantelle Bowers, Malihe Eskandarpour, John Greenwood, Virginia Calder, A. W. Edith Chan, Paul J. Gane, David L. Selwood, Karl Matter, Maria S. Balda
Publikováno v:
Cells, Vol 11, Iss 11, p 1733 (2022)
Inflammation and fibrosis are important components of diseases that contribute to the malfunction of epithelia and endothelia. The Rho guanine nucleotide exchange factor (GEF) GEF-H1/ARHGEF-2 is induced in disease and stimulates inflammatory and fibr
Externí odkaz:
https://doaj.org/article/0936817314424d6bbc31162cfa0c23ff
Autor:
Gabriel Waksman, James Sayer, Tina Daviter, Helen Allan, Alethea B. Tabor, Hans Koss, Karin Walldén, Paul J. Gane
Publikováno v:
Journal of peptide science : an official publication of the European Peptide SocietyREFERENCES. 27(10)
Helicobacter pylori (H. pylori) infections have been implicated in the development of gastric ulcers and various cancers: however, the success of current therapies is compromised by rising antibiotic resistance. The virulence and pathogenicity of H.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39433823636b9c46cb0c82f0d102f236
https://pubmed.ncbi.nlm.nih.gov/34142414
https://pubmed.ncbi.nlm.nih.gov/34142414
Autor:
Nan Yu Chen, Madeleine Zufferey, Paul J. Gane, Neil J. Ball, Cindy Buffone, Lihong Zhou, Giuseppe Nicastro, David L. Selwood, Felipe Diaz-Griffero, Ian A. Taylor, Ariberto Fassati, Jeremy Luban, Silvana Opp
Publikováno v:
Retrovirology
Background HIV-1 capsid influences viral uncoating and nuclear import. Some capsid is detected in the nucleus but it is unclear if it has any function. We reported that the antibiotic Coumermycin-A1 (C-A1) inhibits HIV-1 integration and that a capsid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0944bfa1642568f0265c77e5945d7e08
https://zenodo.org/record/59055
https://zenodo.org/record/59055
Autor:
James R, Sayer, Karin, Walldén, Thomas, Pesnot, Frederick, Campbell, Paul J, Gane, Michela, Simone, Hans, Koss, Floris, Buelens, Timothy P, Boyle, David L, Selwood, Gabriel, Waksman, Alethea B, Tabor
Publikováno v:
Bioorganic & Medicinal Chemistry
Graphical abstract
A novel series of 8-amino imidazo[1,2-a]pyrazine derivatives has been developed as inhibitors of the VirB11 ATPase HP0525, a key component of the bacterial type IV secretion system. A flexible synthetic route to both 2- and 3-
A novel series of 8-amino imidazo[1,2-a]pyrazine derivatives has been developed as inhibitors of the VirB11 ATPase HP0525, a key component of the bacterial type IV secretion system. A flexible synthetic route to both 2- and 3-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::545efa4f16a5791c428b343df109dc92
https://pubmed.ncbi.nlm.nih.gov/25438770
https://pubmed.ncbi.nlm.nih.gov/25438770
Autor:
David L. Selwood, A. W. Edith Chan, Gabriel Waksman, Alvin W. Lo, Paul J. Gane, Karen Van de Water, David Steadman, Kiri Stevens, Han Remaut
Publikováno v:
Journal of Antimicrobial Chemotherapy
Vrije Universiteit Brussel
Vrije Universiteit Brussel
OBJECTIVES:\ud To identify and to characterize small-molecule inhibitors that target the subunit polymerization of the type 1 pilus assembly in uropathogenic Escherichia coli (UPEC).\ud METHODS:\ud Using an SDS-PAGE-based assay, in silico pre-filtere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31708c3de3b33e5a72d7233f13f5b01d
https://pubmed.ncbi.nlm.nih.gov/24324225
https://pubmed.ncbi.nlm.nih.gov/24324225
Publikováno v:
Microbiology and Molecular Biology Reviews. 64:153-179
SUMMARY This review summarizes the recent discovery of the cupin superfamily (from the Latin term “cupa,” a small barrel) of functionally diverse proteins that initially were limited to several higher plant proteins such as seed storage proteins,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d56206a58313de0c1f343ff0192e0e8
https://doi.org/10.1128/mmbr.64.1.153-179.2000
https://doi.org/10.1128/mmbr.64.1.153-179.2000
Publikováno v:
Journal of Molecular Evolution. 46:488-493
It is known that germin, which is a marker of the onset of growth in germinating wheat, is an oxalate oxidase, and also that germins possess sequence similarity with legumin and vicilin seed storage proteins. These two pieces of information have been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b26805090ab674348c30c2bf87031e4
https://doi.org/10.1007/pl00006329
https://doi.org/10.1007/pl00006329
Autor:
R. Hlodan, Robert B. Freedman, Hilary C. Hawkins, Stephen H. McLaughlin, Paul J. Gane, J.W.L. Parry
Publikováno v:
Europe PubMed Central
The high resolution structure of full-length protein disulphide-isomerase (PDI) has not been determined, but the polypeptide is generally assumed to comprise a series of consecutive domains. Models of its domain organisation have been proposed on the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f6914f16464cea39cbc46025107b899
https://doi.org/10.1515/bchm.1998.379.3.321
https://doi.org/10.1515/bchm.1998.379.3.321
Autor:
Amrita Ahluwalia, Reshma S. Baliga, Adrian J. Hobbs, Concepción Peiró, Roberta J. Worthington, Fernando Rivilla, Amie J Moyes, Paul J. Gane, Inmaculada C Villar, Filipa Mota, Natalie G. Lumsden, Snezana Djordjevic, Raymond J. MacAllister, Mark J. Caulfield, Susana Vallejo, Anne Sophie Rebstock, Fang Xiao, David L. Selwood, Carlos F. Sánchez Ferrer, Kristen J. Bubb, Michela I. Simone, Rayomand S. Khambata
Publikováno v:
The Journal of clinical investigation. 124(9)
The endothelium plays a fundamental role in maintaining vascular homeostasis by releasing factors that regulate local blood flow, systemic blood pressure, and the reactivity of leukocytes and platelets. Accordingly, endothelial dysfunction underpins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb059e71868067b469021249ee8c502c
https://pubmed.ncbi.nlm.nih.gov/25105365
https://pubmed.ncbi.nlm.nih.gov/25105365
Autor:
Paul J. Gane, A. W. Edith Chan
Publikováno v:
Protein-Ligand Interactions ISBN: 9781627033978
The discovery of novel biologically active small molecules is now a technologically and economically viable proposition for academic and small biotechnology laboratories wishing to build on their biological research into target proteins. Such small m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df71db9e55f34d0232377d0438e05232
https://doi.org/10.1007/978-1-62703-398-5_18
https://doi.org/10.1007/978-1-62703-398-5_18