p63 is a key regulator of iRHOM2 signalling in the keratinocyte stress response

Autor: Paola Arcidiacono, Catherine M. Webb, Matthew A. Brooke, Huiqing Zhou, Paul J. Delaney, Keat-Eng Ng, Diana C. Blaydon, Andrew Tinker, David P. Kelsell, Anissa Chikh

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)

Mutations in the gene encoding iRHOM2 are associated with hyperproliferative epidermal disorders. Here, the authors show that iRHOM2 is a target gene of p63, that together they regulate inflammation, cell survival and response to oxidative stress, an

Externí odkaz: https://doaj.org/article/c3aea6eca2d04247a2f4d1f9bed1b658

Early inflammation precedes cardiac fibrosis and heart failure in desmoglein 2 murine model of arrhythmogenic cardiomyopathy

Autor: N. Zaman, S.L.M. Walker, Keat-Eng Ng, Joseph Westaby, G. Mastroianni, Ryan C. Pink, S. Murtough, Paul J. Delaney, D. Thenet, Elena Tsisanova, Daniel J. Pennington, C.M. Webb, Andrew Tinker, David P. Kelsell

Publikováno v: Cell and Tissue Research

The study of a desmoglein 2 murine model of arrhythmogenic cardiomyopathy revealed cardiac inflammation as a key early event leading to fibrosis. Arrhythmogenic cardiomyopathy (AC) is an inherited heart muscle disorder leading to ventricular arrhythm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ac543c2bf4bb7d609238d5df700e92a
https://openaccess.sgul.ac.uk/id/eprint/113449/35/Ng2021_Article_EarlyInflammationPrecedesCardi.pdf

RNA sequencing-based transcriptome profiling of cardiac tissue Implicados novela putative disease mechanisms in FLNC-associated arrhythmogenic cardiomyopathy

Autor: Esther Zorio, Charlotte L. Hall, Matthew J. Robertson, Juan Hernandez, Ruth C. Lovering, Juan R. Gimeno, Paul J. Delaney, Mari Paz Suarez, Ali J. Marian, Pilar Molina, Francisco J. Pastor, María Sabater-Molina, Petros Syrris, Cristian Coarfa, Angeliki Asimaki, William J. McKenna, Marta Futema, Priyatansh Gurha, Beatriz Aguilera, Keat-Eng Ng, Sirisha Cheedipudi

Publikováno v: Hall, Charlotte L. Gurha, Priyatansh Sabater-Molina, Maria Asimaki, Angeliki Futema, Marta Lovering, Ruth C. Suárez, Mari Paz Aguilera, Beatriz Molina Aguilar, Pilar Zorio Grima, Esther Coarfa, Cristian Robertson, Matthew J. Cheedipudi, Sirisha M. Keat-Eng Ng. Delaney, Paul Hernández, Juan Pedro Pastor, Francisco Gimeno, Juan R. McKenna, William J. Marian, Ali J. Syrris, Petros 2020 RNA sequencing-based transcriptome profiling of cardiac tissue Implicados novela putative disease mechanisms in FLNC-associated arrhythmogenic cardiomyopathy. International Journal of Cardiology 302 124 130
RODERIC: Repositorio Institucional de la Universitat de Valéncia
instname
RODERIC. Repositorio Institucional de la Universitat de Valéncia
INTERNATIONAL JOURNAL OF CARDIOLOGY
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
Int J Cardiol

Arrhythmogenic cardiomyopathy (ACM) encompasses a group of inherited cardiomyopathies including arrhythmogenic right ventricular cardiomyopathy (ARVC) whose molecular disease mechanism is associated with dysregulation of the canonical WNT signalling

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::971ca3062240f0a47d9688e77064cb0f
https://hdl.handle.net/10550/78744

Loss-of-function desmoplakin I and II mutations underlie dominant arrhythmogenic cardiomyopathy with a hair and skin phenotype

Autor: Edel A. O'Toole, Perry M. Elliott, Paul J. Delaney, A. Posafalvi, Petros Syrris, David P. Kelsell, Andrew Tinker, T. Maruthappu, Silvia Castelletti, Kathleen J. Green, William J. McKenna, Pier D. Lambiase

Publikováno v: The British journal of dermatology. 180(5)

AIMS: Arrhythmogenic Cardiomyopathy (AC) is an inherited, frequently under diagnosed disorder, predisposing to sudden cardiac death. Rare, recessive forms of AC can be associated with woolly hair and palmoplantar keratoderma, but most autosomal domin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed0b1a9b62e8ee0f4f8b10ea48e6676d
https://pubmed.ncbi.nlm.nih.gov/31025732

Impaired myogenic properties of cerebral arteries from the Brown Norway rat

Autor: Paul J. Delaney, Ashley S. Izzard, M P Burnham, Anthony M. Heagerty

Publikováno v: Journal of Hypertension. 30:926-931

Objectives: The Brown Norway rat is highly susceptible to cerebral haemorrhage when hypertension is induced experimentally, compared with the Long Evans. The aims of the study were to compare the myogenic properties and also the collagen-staining pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62d9722bc76f82bb39b93cd9887445b3
https://doi.org/10.1097/hjh.0b013e3283525147