Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Paul J. De Schepper"'
Autor:
Paul J. De Schepper, Christopher J. Hawkey, Peggy H. Wong, Keith Gottesdiener, Barry J. Gertz, John A. Wagner, Lisa DeTora, Nancy G. B. Agrawal, Aimee Dallob, Scott A. Waldman, Nicholas J. Wight, Howard E. Greenberg
Publikováno v:
Scopus-Elsevier
Etoricoxib is a potent selective COX-2 inhibitor in man. Ex vivo whole-blood assays assessed COX-2 inhibition after oral administration of etoricoxib in single (5-500 mg) and multiple (25-150 mg) once-daily doses to healthy human subjects. A separate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdc480df0747abcef4cfecfb8fbee669
https://doi.org/10.1177/0091270003043006003
https://doi.org/10.1177/0091270003043006003
Effect of Montelukast on the Pharmacokinetics and Pharmacodynamics of Warfarin in Healthy Volunteers
Autor:
Barry J. Gertz, Marleen Depré, Amanda Freeman, Sherry D. Holland, Kathleen Wynants, Paul J. De Schepper, René Verbesselt, Peggy H. Wong, Inge De Lepeleire, Jef Arnout, Anne Van Hecken
Publikováno v:
The Journal of Clinical Pharmacology. 39:495-500
Montelukast, a cysteinyl leukotriene receptor antagonist, is being developed for the treatment of asthma and related diseases. This study was designed to evaluate whether montelukast at clinically used dosage levels would interfere with the anticoagu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::887bfea3e54c3b0c5cc82689003af1d6
https://doi.org/10.1177/009127009903900509
https://doi.org/10.1177/009127009903900509
Autor:
Beth Friedman, Aimee Dallob, Sumiko Shingo, Charles Lin, Anne Van Hecken, Inge De Lepeleire, Wesley Tanaka, Paul J. De Schepper, Arturo Porras, Marken Depré
Publikováno v:
Clinical Pharmacology and Therapeutics. 56:22-30
The pharmacodynamics, kinetics, and tolerability of a new orally active 5-lipoxygenase inhibitor were evaluated in healthy male volunteers. MK-0591, 50, 125, and 250 mg every morning and 250 mg every 12 hours, was administered for 10 days. Leukotrien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eedcd31eb0958090c95000b7a0e1db0a
https://doi.org/10.1038/clpt.1994.96
https://doi.org/10.1038/clpt.1994.96
Autor:
Paul J. De Schepper, Paul Michielsen
Publikováno v:
Journal of the American Society of Nephrology : JASN. 12(3)
Analgesic abuse is related to a specific form of interstitial nephritis, but the exact nature of the causal agent remains controversial and this has resulted in differences in regulation. In Flanders, the free sale of phenacetin was banned, but the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e83cb76285b9e204cfa929714b9c0e2
https://pubmed.ncbi.nlm.nih.gov/11181803
https://pubmed.ncbi.nlm.nih.gov/11181803
Autor:
Peggy H. Wong, Barry J. Gertz, Jef Arnout, Marleen Depré, Anne Van Hecken, Wesley Tanaka, David L. Ebel, Kathleen Wynants, Paul J. De Schepper, Aimee Dallob, Inge De Lepeleire, Agnes Buntinx, Jules I. Schwartz
Publikováno v:
Journal of clinical pharmacology. 40(10)
Steady-state inhibitory activity of rofecoxib (Vioxx) on COX-2 versus COX-1 was compared with that of commonly used nonsteroidal anti-inflammatory drugs (NSAIDs) in 76 healthy volunteers randomized to placebo, rofecoxib 12.5 mg qd, rofecoxib 25 mg qd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f8d33a4240f67a7344fdfb872d7c180
https://pubmed.ncbi.nlm.nih.gov/11028250
https://pubmed.ncbi.nlm.nih.gov/11028250
Autor:
Aditi Shahane, Amanda Freeman, Marleen Depré, Inge De Lepeleire, Katleen Wynants, Anne Van Hecken, Sherry D. Holland, René Verbesselt, Barry J. Gertz, Paul J. De Schepper
Publikováno v:
Journal of clinical pharmacology. 39(9)
The effect of multiple oral doses of montelukast, a cysLT 1 receptor antagonist, on the pharmacokinetics of oral digoxin was studied in healthy male volunteers in a randomized double-blind two-period crossover study Subjects received 10 mg of montelu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2268a34af0860827cb87f48953c97232
https://pubmed.ncbi.nlm.nih.gov/10471986
https://pubmed.ncbi.nlm.nih.gov/10471986
Autor:
Donald R. Mehlisch, Arturo G. Porras, Inge De Lepeleire, Johanna Wittreich, Elliot W. Ehrich, Barry J. Gertz, Anne Van Hecken, Wei-ying Yuan, Paul J. De Schepper, Denis Riendeau, James R. Seibold, Aimee Dallob
Publikováno v:
Clinical pharmacology and therapeutics. 65(3)
Background Nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, ibuprofen, and indomethacin (INN, indometacin) inhibit both the constitutive (COX-1) and inducible (COX-2) isoforms of cyclooxygenase. The induction of COX-2 after inflammatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93b1ccb7d0f9c3f16e76bdfc586d3f9c
https://pubmed.ncbi.nlm.nih.gov/10096266
https://pubmed.ncbi.nlm.nih.gov/10096266
Publikováno v:
Clinical pharmacology and therapeutics. 52(4)
A four-period, two-panel single rising-dose study (0.1 to 100 mg) was conducted in healthy men to investigate the pharmacodynamics and tolerability of L-654,066, a steroid 5 alpha-reductase inhibitor. Within each panel, six subjects received L-654,06
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5753680b733bb2d9c5d9753e7e302f51
https://pubmed.ncbi.nlm.nih.gov/1424413
https://pubmed.ncbi.nlm.nih.gov/1424413
Autor:
Anne Van Hecken, Inge De Lepeleire, Julianne Imperato-McGinley, Elizabeth Stoner, Josephine R. Carlin, Paul J. De Schepper, Agnes Buntinx, Mary H. Gressi
Publikováno v:
Steroids. 56(9)
The hormonal effects following the acute (single dose) administration of a 4-azasteroid inhibitor of 5 alpha-reductase (MK-906) were evaluated in 10 healthy male volunteers. Marked suppression of serum dihydrotestosterone (DHT) was observed after the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dca113bbccea4b40370cdfbaca32b58e
https://pubmed.ncbi.nlm.nih.gov/1666698
https://pubmed.ncbi.nlm.nih.gov/1666698
Autor:
Paul Michielsen, Paul J. De Schepper
Publikováno v:
American Journal of Kidney Diseases. 28:958-959
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d641552373636136d49ae74e43fb16cd
https://doi.org/10.1016/s0272-6386(96)90402-3
https://doi.org/10.1016/s0272-6386(96)90402-3